99 research outputs found
Temperature dependence of ESR intensity for the nanoscale molecular magnet V15
The electron spin resonance (ESR) of nanoscale molecular magnet is studied. Since the Hamiltonian of has a large
Hilbert space and numerical calculations of the ESR signal evaluating the Kubo
formula with exact diagonalization method is difficult, we implement the
formula with the help of the random vector technique and the Chebyshev
polynominal expansion, which we name the double Chebyshev expansion method. We
calculate the temperature dependence of the ESR intensity of and
compare it with the data obtained in experiment. As another complementary
approach, we also implement the Kubo formula with the subspace iteration method
taking only important low-lying states into account. We study the ESR
absorption curve below by means of both methods. We find that side
peaks appear due to the Dzyaloshinsky-Moriya interaction and these peaks grows
as temperature decreases.Comment: 9 pages, 4 figures. To appear in J. Phys. Soc. Jpn. Supp
Asymptotic Expansions for Stationary Distributions of Perturbed Semi-Markov Processes
New algorithms for computing of asymptotic expansions for stationary
distributions of nonlinearly perturbed semi-Markov processes are presented. The
algorithms are based on special techniques of sequential phase space reduction,
which can be applied to processes with asymptotically coupled and uncoupled
finite phase spaces.Comment: 83 page
Sequence Defined Disulfide-Linked Shuttle for Strongly Enhanced Intracellular Protein Delivery
Intracellular protein transduction technology is opening the door for a promising alternative to gene therapy. Techniques have to address all critical steps, like efficient cell uptake, endolysosomal escape, low toxicity, while maintaining full functional activity of the delivered protein. Here, we present the use of a chemically precise, structure defined three-arm cationic oligomer carrier molecule for protein delivery. This carrier of exact and low molecular weight combines good cellular uptake with efficient endosomal escape and low toxicity. The protein cargo is covalently attached by a bioreversible disulfide linkage. Murine 3T3 fibroblasts could be transduced very efficiently with cargo nlsEGFP, which was tagged with a nuclear localization signal. We could show subcellular delivery of the nlsEGFP to the nucleus, confirming cytosolic delivery and expected subsequent subcellular trafficking. Transfection efficiency was concentration-dependent in a directly linear mode and 20-fold higher in comparison with HIV-TAT-nlsEGFP containing a functional TAT transduction domain. Furthermore, β-galactosidase as a model enzyme cargo, modified with the carrier oligomer, was transduced into neuroblastoma cells in enzymatically active form
Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations
Blast-induced traumatic brain injury has been associated with neurodegenerative and neuropsychiatric disorders. To date, although damage due to oxidative stress appears to be important, the specific mechanistic causes of such disorders remain elusive. Here, to determine the mechanical variables governing the tissue damage eventually cascading into cognitive deficits, we performed a study on the mechanics of rat brain under blast conditions. To this end, experiments were carried out to analyse and correlate post-injury oxidative stress distribution with cognitive deficits on a live rat exposed to blast. A computational model of the rat head was developed from imaging data and validated against in vivo brain displacement measurements. The blast event was reconstructed in silico to provide mechanistic thresholds that best correlate with cognitive damage at the regional neuronal tissue level, irrespectively of the shape or size of the brain tissue types. This approach was leveraged on a human head model where the prediction of cognitive deficits was shown to correlate with literature findings. The mechanistic insights from this work were finally used to propose a novel helmet design roadmap and potential avenues for therapeutic innovations against blast traumatic brain injury
Africa’s contribution to the worldwide research literature: New analytical perspectives, trends, and performance indicators
Nirvana by Numbers: Comparison between MFA and PLS Approaches on an Example
T. Aluja, J. Casanovas, V. Esposito Vinzi, A. Morineau, M. Tenenhaus (eds.)-
SPAD Groupe Test&G
Modelling the impulse diffraction field of shear waves in transverse isotropic viscoelastic medium
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