International river basin management : a case study of the Okavango River Basin.

Thesis (M.Env.Dev.)-University of Natal, Pietermaritzburg, 2002.This dissertation reviews the principles of International River Basin Management and their application by the governments of Angola, Botswana and Namibia. The dissertation deals with the issues popularised by governments, water planners and international agencies that the twenty-first century's conflicts will be fought over water. Increasingly this concern is being used to justify new water-supply dams and river diversion projects. This is especially so in arid Southern Africa, the focus of this dissertation, where numerous major international water transfers are underway and many more are being planned. While Namibia's growing thirst is a serious problem, the story is more complicated than just too many basin states putting their straws into one glass. The growing conflicts over the Okavango's water use raise broader questions about ownership of common resources, and equity of access to those resources. Most southern African countries depend on primary natural resources to sustain economies and their people. The environmental issues are remarkably similar in countries within the region, and the economic, social and political fortunes of the individual countries are intertwined. Furthermore, the ways in which resources are being managed are similar and thus cause for common concern. In general, the ability of countries in the region to achieve sustainable development depends not on national policies but also on the commitment of neighbours to practice sound environmental management. This is because activities in one country can easily cause impacts on a neighbour and possibly result in "downstream" opportunity costs. This case study of the Okavango River Basin, a river facing prospective developments from riparian states Angola, Botswana and Namibia, attempts to find sustainable solutions to solving international resource conflict. In addition to outlining the possible future threats to the Okavango River, this study proclaims a number of recommendations in the way of declaring alternatives to Namibia's plans to extract water from the Okavango River. One such recommendation is the encouragement of Water Demand Management as an alternative to water transfer by Namibia. This management strategy is aimed at optimising the use of available water rather than developing new or extended supplies and as a result it has a vital role to play since it contributes to sustainable development rather than over exploitation of limited natural resources. The majority of large rivers in the Southern African Development Community (SADC) are shared by three or more countries, and as the region's water resources come under growing development pressure, the importance of establishing effective national and regional methods and institutions for sustainably managing these resources will increase greatly. From economic, ecological and human welfare perspectives, the Okav,ango River Basin is arguably one of the most important transboundary natural resources (TBNR) in the region. Owing to the basin's remoteness and history of conflict, the Okavango was spared much of the destructive developments that rivers in the region have suffered. As a result, the relatively pristine Okavango ecosystem continues to provide significant benefits to the region much as it has done for centuries. As we approach the new millennium, however, it is clear that the health of the Okavango River Basin is threatened as riparian states increasingly turn to the Okavango to support their growing populations and economies

Construction material processed using lunar simulant in various environments

The manufacture of construction materials from locally available resources in space is an important first step in the establishment of lunar and planetary bases. The objective of the CoMPULSIVE (Construction Material Processed Using Lunar Simulant In Various Environments) experiment is to develop a procedure to produce construction materials by sintering or melting Johnson Space Center Simulant 1 (JSC-1) lunar soil simulant in both earth-based (1-g) and microgravity (approximately 0-g) environments. The characteristics of the resultant materials will be tested to determine its physical and mechanical properties. The physical characteristics include: crystalline, thermal, and electrical properties. The mechanical properties include: compressive tensile, and flexural strengths. The simulant, placed in a sealed graphite crucible, will be heated using a high temperature furnace. The crucible will then be cooled by radiative and forced convective means. The core furnace element consists of space qualified quartz-halogen incandescent lamps with focusing mirrors. Sample temperatures of up to 2200 C are attainable using this heating method

Evidence for hierarchical black hole mergers in the second LIGO--Virgo gravitational-wave catalog

We study the population properties of merging binary black holes in the second LIGO--Virgo Gravitational-Wave Transient Catalog assuming they were all formed dynamically in gravitationally bound clusters. Using a phenomenological population model, we infer the mass and spin distribution of first-generation black holes, while self-consistently accounting for hierarchical mergers. Considering a range of cluster masses, we see compelling evidence for hierarchical mergers in clusters with escape velocities $\gtrsim 100~\mathrm{km\,s^{-1}}$. For our most probable cluster mass, we find that the catalog contains at least one second-generation merger with $99\%$ credibility. We find that the hierarchical model is preferred over an alternative model with no hierarchical mergers (Bayes factor $\mathcal{B} > 1400$) and that GW190521 is favored to contain two second-generation black holes with odds $\mathcal{O}>700$, and GW190519, GW190602, GW190620, and GW190706 are mixed-generation binaries with $\mathcal{O} > 10$. However, our results depend strongly on the cluster escape velocity, with more modest evidence for hierarchical mergers when the escape velocity is $\lesssim 100~\mathrm{km\,s^{-1}}$. Assuming that all binary black holes are formed dynamically in globular clusters with escape velocities on the order of tens of $\mathrm{km\,s^{-1}}$, GW190519 and GW190521 are favored to include a second-generation black hole with odds $\mathcal{O}>1$. In this case, we find that $99\%$ of black holes from the inferred total population have masses that are less than $49\,M_{\odot}$, and that this constraint is robust to our choice of prior on the maximum black hole mass.Comment: 15 pages, 11 figures, 1 appendi

Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis

Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide production. In animal models of arthritis, treatment with recombinant human IL-11 (rhIL-11) reduces both the level of synovitis and the histologic lesion scores in the joints. The goal of this phase-I/II study in adults with rheumatoid arthritis (RA) was to evaluate the safety and clinical activity of different doses and schedules of rhIL-11 in patients with active RA for whom treatment with at least one disease-modifying antirheumatic drug had failed. This was a multicenter, randomized, placebo-controlled trial that evaluated the safety and tolerability of rhIL-11 in 91 patients with active RA. rhIL-11 was administered subcutaneously; patients were randomized into one of five treatment groups (ratio of rhIL-11 to placebo, 4:1). Patients were treated for 12 weeks with either 2.5 or 7.5 μg/kg of rhIL-11 or placebo twice per week or 5 or 15 μg/kg of rhIL-11 or placebo once per week. The status of each subject's disease activity in accordance with the American College of Rheumatology (ACR) criteria was assessed before, during, and after completion of administration of the study drug. Administration of rhIL-11 was well tolerated at all doses and schedules. The most frequent adverse event was a reaction at the injection site. The data suggest a statistically significant reduction in the number of tender joints (P < 0.008) at the 15 μg/kg once-weekly dose schedule but showed no overall significant benefit at the ACR criterion of a 20% response. The trial showed rhIL-11 to be safe and well tolerated at a variety of doses and schedules over a 12-week treatment period in patients with active RA. The only adverse event clearly associated with rhIL-11 administration was reaction at the injection site

Neuropsychological Findings in Idiopathic Adult-Onset Epilepsy Case Study: Noorda COM Student Investigation

We report the case of a 25-year-old male patient with idiopathic adult-onset epilepsy. The patient presented with a chief complaint of recurrent seizures and no identifiable cause. These seizures were associated with a lack of extremity control, muscle spasms, and loss of cognitive function. His condition began while living in Thailand, where he experienced multiple environmental stressors including hostile living conditions and tense situations, approximately five years before being seen in the clinic. Over the past several years, the seizures have not ceased, and the patient now notes a loss or decrease of several special senses

Ancient Lowland Maya neighborhoods: Average Nearest Neighbor analysis and kernel density models, environments, and urban scale

Many humans live in large, complex political centers, composed of multi-scalar communities including neighborhoods and districts. Both today and in the past, neighborhoods form a fundamental part of cities and are defined by their spatial, architectural, and material elements. Neighborhoods existed in ancient centers of various scales, and multiple methods have been employed to identify ancient neighborhoods in archaeological contexts. However, the use of different methods for neighborhood identification within the same spatiotemporal setting results in challenges for comparisons within and between ancient societies. Here, we focus on using a single method—combining Average Nearest Neighbor (ANN) and Kernel Density (KD) analyses of household groups—to identify potential neighborhoods based on clusters of households at 23 ancient centers across the Maya Lowlands. While a one-size-fits all model does not work for neighborhood identification everywhere, the ANN/KD method provides quantifiable data on the clustering of ancient households, which can be linked to environmental zones and urban scale. We found that centers in river valleys exhibited greater household clustering compared to centers in upland and escarpment environments. Settlement patterns on flat plains were more dispersed, with little discrete spatial clustering of households. Furthermore, we categorized the ancient Maya centers into discrete urban scales, finding that larger centers had greater variation in household spacing compared to medium-sized and smaller centers. Many larger political centers possess heterogeneity in household clustering between their civic-ceremonial cores, immediate hinterlands, and far peripheries. Smaller centers exhibit greater household clustering compared to larger ones. This paper quantitatively assesses household clustering among nearly two dozen centers across the Maya Lowlands, linking environment and urban scale to settlement patterns. The findings are applicable to ancient societies and modern cities alike; understanding how humans form multi-scalar social groupings, such as neighborhoods, is fundamental to human experience and social organization

Low Energy Nuclear Reaction Aircraft- 2013 ARMD Seedling Fund Phase I Project

This report serves as the final written documentation for the Aeronautic Research Mission Directorate (ARMD) Seedling Fund's Low Energy Nuclear Reaction (LENR) Aircraft Phase I project. The findings presented include propulsion system concepts, synergistic missions, and aircraft concepts. LENR is a form of nuclear energy that potentially has over 4,000 times the energy density of chemical energy sources. It is not expected to have any harmful emissions or radiation which makes it extremely appealing. There is a lot of interest in LENR, but there are no proven theories. This report does not explore the feasibility of LENR. Instead, it assumes that a working system is available. A design space exploration shows that LENR can enable long range and high speed missions. Six propulsion concepts, six missions, and four aircraft concepts are presented. This report also includes discussion of several issues and concerns that were uncovered during the study and potential research areas to infuse LENR aircraft into NASA's aeronautics research

Mitochondrial Data in Monocot Phylologenetics

Mitochondrial sequences are an important source of data in animal phylogenetics, equivalent in importance to plastid sequences in plants. However, in recent years plant systematists have begun exploring the mitochondrial genome as a source of phylogenetically useful characters. The plant mitochondrial genome is renowned for its variability in size, structure, and gene organization, but this need not be of concern for the application of sequence data in phylogenetics. However, the incorporation of reverse transcribed mitochondrial genes ( processed paralogs ) and the recurring transfer of genes from the mitochondrion to the nucleus are evolutionary events that must be taken into account. RNA editing of mitochondrial genes is sometimes considered a problem in phylogenetic reconstruction, but we regard it only as a mechanism that may increase variability at edited sites and change the codon position bias accordingly. Additionally, edited sites may prove a valuable tool in identifying processed paralogs. An overview of genes and sequences used in phylogenetic studies of angiosperms is presented. In the monocots, a large amount of mitochondrial sequence data is being collected together with sequence data from plastid and nuclear genes, thus offering an opportunity to compare data from different genomic compartments. The mitochondrial and plastid data are incongruent when organelle gene trees are reconstructed. Possible reasons for the observed incongruence involve sampling of paralogous sequences and highly divergent substitution rates, potentially leading to longbranch attraction. The above problems are addressed in Acorales, Alismatales, Poales, Liliaceae, the Anthericum clade (in Agavaceae), and in some achlorophyllous taxa