Gemini Spectroscopic Survey of Young Star Clusters in Merging/Interacting Galaxies. IV. Stephan's Quintet

We present a spectroscopic survey of 21 young massive clusters and complexes and one tidal dwarf galaxy candidate (TDG) in Stephan's Quintet, an interacting compact group of galaxies. All of the selected targets lie outside the main galaxies of the system and are associated with tidal debris. We find clusters with ages between a few and 125 Myr and confirm the ages estimated through HST photometry by Fedotov et al. (2011), as well as their modelled interaction history of the Quintet. Many of the clusters are found to be relatively long-lived, given their spectrosopically derived ages, while their high masses suggest that they will likely evolve to eventually become intergalactic clusters. One cluster, T118, is particularly interesting, given its age (\sim 125 Myr), high mass (\sim 2\times10^6 M\odot) and position in the extreme outer end of the young tidal tail. This cluster appears to be quite extended (Reff \sim 12 - 15 pc) compared to clusters observed in galaxy disks (Reff \sim 3 - 4 pc), which confirms an effect we previously found in the tidal tails of NGC 3256, where clusters are similarly extended. We find that star and cluster formation can proceed at a continuous pace for at least \sim 150 Myr within the tidal debris of interacting galaxies. The spectrum of the TDG candidate is dominated by a young population (\sim 7 Myr), and assuming a single age for the entire region, has a mass of at least 10^6 M\odot.Comment: 37 pages, 10 Figures, 7 Tabl

Public attitudes towards bystander CPR and their association with social deprivation: Findings from a cross sectional study in North England

Background Bystander cardiopulmonary resuscitation (BCPR) is undertaken in only 40% of out of hospital cardiac arrests (OHCAs) in the UK. Lower rates of BCPR and public access defibrillator (PAD) use have been correlated with lower socio-economic status (SES). The aim of this study was to examine knowledge and attitudes towards BCPR and PAD’s using a study specific questionnaire, and to understand how these potentially interact with individual characteristics and SES. Methods Cross-sectional study between July-December 2021 across areas of varying SES in North England. Results Six hundred and one individuals completed the survey instrument (mean age = 51.9 years, 52.2 % female). Increased age was associated with being less willing to call 999 (p < 0.001) and follow call handler advice (p < 0.001). Female respondents were less comfortable performing BCPR than male respondents (p = 0.006). Individuals from least deprived areas were less likely to report comfort performing CPR, (p = 0.016) and less likely to know what a PAD is for, (p = 0.025). Higher education level was associated with increased ability to recognise OHCA (p = 0.005) and understanding of what a PAD is for (p < 0.001). Individuals with higher income were more likely to state they would follow advice regarding BCPR (p = 0.017) and report comfort using a PAD (p = 0.029). Conclusion Individual characteristics such as age and ethnicity, rather than SES, are indicators of knowledge, willingness, and perceived competency to perform BCPR. Policy makers should avoid using SES alone to target interventions. Future research should examine how cultural identity and social cohesion intersect with these characteristics to influence willingness to perform BCPR

Socio-economic status has a limited association with knowledge and attitudes towards bystander cardiopulmonary resuscitation: a cross-sectional study in North England

Background: Bystander cardiopulmonary resuscitation (BCPR) is a critical link in the ‘Chain of Survival’, yet in the UK, is undertaken in only 40% of out of hospital cardiac arrests (OHCAs). Lower rates of BCPR have been correlated with lower socio-economic status (SES). This study aimed to explore how knowledge and attitudes about BCPR linked to SES across North East and North Cumbria in England. Methods: Cross-sectional study between July-December 2021 surveying individuals from areas of varying SES. Results: Six hundred and one individuals completed the survey instrument (mean age=51.9 years, range=18-95, standard deviation=17.7; 52.2% (n=313) female). Increased age was associated with being less willing to call 999 (p<0.001) and follow call handler advice (p<0.001). Female respondents were less comfortable performing BCPR than male respondents (p=0.006). Individuals from least deprived areas were less likely to report comfort performing CPR, (p=0.016) and less likely to know what a Public Access Defibrillator (PAD) is for, (p=0.025). Higher education level was associated with increased ability to recognise OHCA (p=0.005) and understanding of what a PAD is for (p<0.001). Individuals with higher income were more likely to follow advice regarding BCPR (p=0.017) and report comfort using a PAD (p=0.029). Conclusion: SES is a poor indicator of knowledge, willingness, and perceived competency to perform BCPR. Policy makers should avoid using SES alone to target interventions and focus more on individual characteristics such as age and ethnicity. Future research should examine how cultural identity and social cohesion intersect with these characteristics to influence willingness to perform BCPR

The effects of adrenaline in out of hospital cardiac arrest with shockable and non-shockable rhythms : findings from the PACA and PARAMEDIC-2 randomised controlled trials

Introduction Previous research suggests there may be differences in the effects of adrenaline related to the initial cardiac arrest rhythm. The aim of this study was to assess the effect of adrenaline compared with placebo according to whether the initial cardiac arrest rhythm was shockable or non-shockable. Methods Return of spontaneous circulation (ROSC), survival and neurological outcomes according to the initial arrest rhythm were compared amongst patients enrolled in the PARAMEDIC-2 randomised, placebo controlled trial. The results of the PARAMEDIC-2 and PACA out of hospital cardiac arrest trials were combined and meta-analysed. Results The initial rhythm was known for 3,929 (98.2%) in the placebo arm and 3,919 (97.6%) in the adrenaline arm. The effect on the rate of ROSC of adrenaline relative to placebo was greater in patients with non-shockable cardiac rhythms (1002/3003 (33.4%) versus 222/3005 (7.4%), adjusted OR: 6.5, (95% CI 5.6-7.6)) compared with shockable rhythms 349/716 (48.7%) versus (208/702 (29.6%), adjusted OR: 2.3, 95%CI: 1.9-2.9)). The adjusted odds ratio for survival at discharge for non-shockable rhythms was 2.5 (1.3, 4.8) and 1.3 (0.9, 1.8) for shockable rhythms (P value for interaction 0.065) and 1.8(0.8-4.1) and 1.1 (0.8-1.6) respectively for neurological outcome at discharge (P value for interaction 0.295). Meta-analysis found similar results. Conclusion Relative to placebo, the effects of adrenaline ROSC are greater for patients with an initially non-shockable rhythm than those with a shockable rhythms. Similar patterns are observed for longer term survival outcomes and favourable neurological outcomes, although the differences in effects are less pronounced

I don’t want to put myself in harm’s way trying to help somebody: public knowledge and attitudes towards bystander CPR in North East England – findings from a qualitative interview study

Background: Bystander cardiopulmonary resuscitation (BCPR), and public access defibrillator (PAD) use are essential links in the ‘Chain of Survival’ for out of hospital cardiac arrest (OHCA). In England, BCPR is delivered in only 40% of cases and population-level studies suggest this may be because of lower socio-economic status (SES). There is little qualitative evidence exploring BCPR and SES in Northern England. The aim of this study was to explore the perceptions and willingness of members of the public to deliver BCPR and use a PAD in communities of varying SES across Northern England. Methods: In-depth interviews between September 2021–January 2022 with 20 participants. Interviews were transcribed verbatim and analysed using reflexive thematic analysis. Findings: Perceptions and attitudes towards BCPR were underpinned by multiple, intersecting factors, contextualised by the individual’s unique societal position. A poor understanding of BCPR and very limited knowledge of PAD use was identified, precipitated by language and education marginalisation. Willingness and confidence to attempt BCPR was driven by a sense of social cohesion. Barriers to delivering BCPR initiatives centred upon difficulties with engagement in all communities, particularly closed communities and those not in employment. Conclusions: Willingness and ability to deliver BCPR lie beyond SES alone. Future initiatives to improve rates of BCPR should take an intersectional, place-based approach, and be co-developed in conjunction with local communities and delivered in a format that people find convenient. Further research is required to understand how targeted initiatives should be delivered and how these result in improved outcomes from OHCA

Hierarchical Hough all-sky search for periodic gravitational waves in LIGO S5 data

We describe a new pipeline used to analyze the data from the fifth science run (S5) of the LIGO detectors to search for continuous gravitational waves from isolated spinning neutron stars. The method employed is based on the Hough transform, which is a semi-coherent, computationally efficient, and robust pattern recognition technique. The Hough transform is used to find signals in the time-frequency plane of the data whose frequency evolution fits the pattern produced by the Doppler shift imposed on the signal by the Earth's motion and the pulsar's spin-down during the observation period. The main differences with respect to previous Hough all-sky searches are described. These differences include the use of a two-step hierarchical Hough search, analysis of coincidences among the candidates produced in the first and second year of S5, and veto strategies based on a $\chi^2$ test.Comment: 7 pages, 2 figures, Amaldi08 proceedings, submitted to JPC

A randomized trial of epinephrine in out-of-hospital cardiac arrest

Background Concern about the use of epinephrine as a treatment for out-of-hospital cardiac arrest led the International Liaison Committee on Resuscitation to call for a placebo-controlled trial to determine whether the use of epinephrine is safe and effective in such patients. Methods In a randomized, double-blind trial involving 8014 patients with out-of-hospital cardiac arrest in the United Kingdom, paramedics at five National Health Service ambulance services administered either parenteral epinephrine (4015 patients) or saline placebo (3999 patients), along with standard care. The primary outcome was the rate of survival at 30 days. Secondary outcomes included the rate of survival until hospital discharge with a favorable neurologic outcome, as indicated by a score of 3 or less on the modified Rankin scale (which ranges from 0 [no symptoms] to 6 [death]). Results At 30 days, 130 patients (3.2%) in the epinephrine group and 94 (2.4%) in the placebo group were alive (unadjusted odds ratio for survival, 1.39; 95% confidence interval [CI], 1.06 to 1.82; P=0.02). There was no evidence of a significant difference in the proportion of patients who survived until hospital discharge with a favorable neurologic outcome (87 of 4007 patients [2.2%] vs. 74 of 3994 patients [1.9%]; unadjusted odds ratio, 1.18; 95% CI, 0.86 to 1.61). At the time of hospital discharge, severe neurologic impairment (a score of 4 or 5 on the modified Rankin scale) had occurred in more of the survivors in the epinephrine group than in the placebo group (39 of 126 patients [31.0%] vs. 16 of 90 patients [17.8%]). Conclusions In adults with out-of-hospital cardiac arrest, the use of epinephrine resulted in a significantly higher rate of 30-day survival than the use of placebo, but there was no significant between-group difference in the rate of a favorable neurologic outcome because more survivors had severe neurologic impairment in the epinephrine group. (Funded by the U.K. National Institute for Health Research and others; Current Controlled Trials number, ISRCTN73485024.

Sex- and age-specific trends in mortality from suicide and undetermined death in Germany 1991–2002

BACKGROUND: Over the last decade, significant downward linear time trends in suicide mortality were observed in most Western countries. To date, it is not established whether those favourable time trends developed homogeneously for sex and age groups and how they were affected by the number of undetermined deaths. METHODS: Data on suicide mortality and undetermined death from 1991 to 2002 in Germany were obtained from the German Federal Statistical Office. For each year, the age-standardised suicide rate (SR), undetermined death rate (UDR) and total rate (SR+UDR) was calculated by direct standardisation separately for men and women. Time trends were analyzed by Poisson regression estimating the average annual percentage change (AAPC) of the rates for sex and four age groups (15–24, 25–44, 45–74, ≥ 75 years). RESULTS: A significant decline of the SR was observed in all age groups but was less pronounced among the younger ages, particularly among men aged 15–24 years (AAPC -0.7%, p = 0.041). The SR in the oldest male age group (≥ 75 years) declined much stronger (AAPC -3.5%, p < 0.001). In women, the AAPC of the SR ranged from -1.7% to -4.6%. The average annual percentage changes in the age groups 25 – 74 years did not differ substantially for SR and SR+UDR. In contrast, due to an increase of undetermined deaths for subjects ≥ 75 years, time trends in this age group were affected by the number of undetermined deaths, especially in women. CONCLUSION: Observing downward trends in suicide mortality with lower declines for younger subjects, prevention strategies should focus in particular on younger subjects