The entorhinal cognitive map is attracted to goals

Grid cells with their rigid hexagonal firing fields are thought to provide an invariant metric to the hippocampal cognitive map, yet environmental geometrical features have recently been shown to distort the grid structure. Given that the hippocampal role goes beyond space, we tested the influence of nonspatial information on the grid organization. We trained rats to daily learn three new reward locations on a cheeseboard maze while recording from the medial entorhinal cortex and the hippocampal CA1 region. Many grid fields moved toward goal location, leading to long-lasting deformations of the entorhinal map. Therefore, distortions in the grid structure contribute to goal representation during both learning and recall, which demonstrates that grid cells participate in mnemonic coding and do not merely provide a simple metric of space

Dissociation between postrhinal cortex and downstream parahippocampal regions in the representation of egocentric boundaries

Navigation requires the integration of many sensory inputs to form a multi-modal cognitive map of the environment, which is believed to be implemented in the hippocampal region by spatially tuned cells [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. These cells encode various aspects of the environment in a world-based (allocentric) reference frame. Although the cognitive map is represented in allocentric coordinates, the environment is sensed through diverse sensory organs, mostly situated in the animal’s head, and therefore represented in sensory and parietal cortices in head-centered egocentric coordinates. Yet it is not clear how and where the brain transforms these head-centered egocentric representations to map-like allocentric representations computed in the hippocampal region. Theoretical modeling has predicted a role for both egocentric and head direction (HD) information in performing an egocentric-allocentric transformation [ 11 , 12 , 13 , 14 , 15 ]. Here, we recorded new data and also used data from a previous study [ 16 ]. Adapting a generalized linear model (GLM) classification [ 17 ]; we show that the postrhinal cortex (POR) contains a population of pure egocentric boundary cells (EBCs), in contrast with the conjunctive EBCs × HD cells, which we found downstream mostly in the parasubiculum (PaS) and in the medial entorhinal cortex (MEC). Our finding corroborates the idea of a brain network performing an egocentric to allocentric transformation by HD cells. This is a fundamental building block in the formation of the brain’s internal cognitive map

Grid cells in pre- and parasubiculum

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