Performance Analysis of Superconductor-constriction-Superconductor Transmon Qubits

This work presents a computational analysis of a superconducting transmon qubit design, in which the superconductor-insulator-superconductor (SIS) Josephson junction is replaced by a co-planar, superconductor-constriction-superconductor (ScS) junction. For short junctions having a Kulik-Omelyanchuk current-phase relationship, we find that the ScS transmon has an improved charge dispersion compared to the SIS transmon, with a tradeoff of 50% smaller anharmonicity. These calculations provide a framework for estimating the superconductor material properties and junction dimensions needed to provide proper ScS transmon operation at typical gigahertz frequencies.Comment: 8 pages, 8 figure

Perceptions of unsolicited electronic mail or spam

The proliferation of unsolicited electronic mail or spam is becoming a global concern for many organizations. This paper explores perceptions of unsolicited email, its impact on personal productivity, the question of whether spam is an invasion of privacy, the perceived need to control spam, and the effectiveness of unsolicited email. The results clearly show that while the respondents find spam annoying, they spend very little time in dealing with it. Although the respondents express the need to control spam, they do not believe that governmental control is the solution, but rather that Internet Service Providers and organizations should take the responsibility for controlling unsolicited email. Lastly, the respondents are very unlikely to open, let alone read, and respond to unsolicited email. The results of this study will be useful for guiding organizational, university, and public policies

How well do antivirals shorten genital herpes pain duration?

Q: How well do antivirals shorten genital herpes pain duration? Evidence-based answer: Oral and intravenous (IV) acyclovir each shorten the duration of pain for a first primary outbreak of herpes by about 50%; topical acyclovir shortens it by about 25% (strength of recommendation [SOR]: B, small randomized controlled trials [RCTs] with some methodological flaws). Oral valacyclovir and famcyclovir are equivalent to oral acyclovir. Adding topical acyclovir to oral acyclovir doesn't produce additional benefit (SOR: B, RCTs). Patients with severe disease may require IV acyclovir (SOR: C, expert opinion). General treatment measures that may improve patient comfort include keeping lesions clean and dry, avoiding tight clothing, taking analgesics, and using ice packs or taking warm baths (SOR: C, expert opinion). Evidence for using complementary and alternative medicine to treat genital herpes is lacking or conflicting [SOR: C, narrative review of clinical trials]

The Faint End Slopes Of Galaxy Luminosity Functions In The COSMOS 2-Square Degree Field

We examine the faint-end slope of the rest-frame V-band luminosity function (LF), with respect to galaxy spectral type, of field galaxies with redshift z<0.5, using a sample of 80,820 galaxies with photometric redshifts in the Cosmic Evolution Survey (COSMOS) field. For all galaxy spectral types combined, the LF slope, alpha, ranges from -1.24 to -1.12, from the lowest redshift bin to the highest. In the lowest redshift bin (0.02<z<0.1), where the magnitude limit is M(V) ~ -13, the slope ranges from ~ -1.1 for galaxies with early-type spectral energy distributions (SEDs), to ~ -1.9 for galaxies with low-extinction starburst SEDs. In each galaxy SED category (Ell, Sbc, Scd/Irr, and starburst), the faint-end slopes grow shallower with increasing redshift; in the highest redshift bin (0.4<z<0.5), the slope is ~ -0.5 and ~ -1.3 for early-types and starbursts respectively. The steepness of alpha at lower redshift could be qualitatively explained by large numbers of faint dwarf galaxies, perhaps of low surface brightness, which are not detected at higher redshifts.Comment: 24 pages including 5 figures, accepted to ApJ

Control of Josephson current by Aharonov-Casher Phase in a Rashba Ring

We study the interference effect induced by the Aharonov-Casher phase on the Josephson current through a semiconducting ring attached to superconducting leads. Using a 1D model that incorporates spin-orbit coupling in the semiconducting ring, we calculate the Andreev levels analytically and numerically, and predict oscillations of the Josephson current due to the AC phase. This result is valid from the point contact limit to the long channel length limit, as defined by the ratio of the junction length and the BCS healing length. We show in the long channel length limit that the impurity scattering has no effect on the oscillation of the Josephson current, in contrast to the case of conductivity oscillations in a spin-orbit coupled ring system attached to normal leads where impurity scattering reduces the amplitude of oscillations. Our results suggest a new scheme to measure the AC phase with, in principle, higher sensitivity. In addition, this effect allows for control of the Josephson current through the gate voltage tuned AC phase.Comment: 12pages, 8 figure

Extremely Red Objects in the Field of QSO 1213-0017: A Galaxy Concentration at z=1.31

We have discovered a concentration of extremely red objects (EROs; R-K>6) in the field of the z=2.69 quasar QSO 1213-0017 (UM 485), which is significantly overabundant compared to the field ERO surface density. The optical/near-IR colors of the EROs and numerous other red galaxies in this field are consistent with elliptical galaxies at z=1-2. HST optical images for a subset of galaxies show regular morphologies, most of them being disky or diffuse and without any obvious evidence for interactions. Ground-based IR images show similar morphologies, indicating any dust reddening in these objects is spatially uniform. Optical spectroscopy with the W. M. Keck Telescope has found that four of the red galaxies lie at =1.31, and a fifth lies in the foreground at z=1.20. Of the =1.31 galaxies, one is a reddened AGN while the remaining three have rest-frame UV absorption-line spectra characteristic of old (few Gyr) stellar populations, similar to the old red galaxy LBDS 53W091 at z=1.55. Including the MgII absorber seen in the QSO spectrum, we find five galaxies at =1.31 spread over 1.5 h_50^{-1} Mpc on the sky. These results suggest we have discovered a coherent structure of old galaxies at high-redshift, possibly associated with a massive galaxy cluster.Comment: 37 pages including 11 Postscript figures. To appear in the June 2000 issue of the Astronomical Journa

Independent component analysis of Alzheimer's DNA microarray gene expression data

<p>Abstract</p> <p>Background</p> <p>Gene microarray technology is an effective tool to investigate the simultaneous activity of multiple cellular pathways from hundreds to thousands of genes. However, because data in the colossal amounts generated by DNA microarray technology are usually complex, noisy, high-dimensional, and often hindered by low statistical power, their exploitation is difficult. To overcome these problems, two kinds of unsupervised analysis methods for microarray data: principal component analysis (PCA) and independent component analysis (ICA) have been developed to accomplish the task. PCA projects the data into a new space spanned by the principal components that are mutually orthonormal to each other. The constraint of mutual orthogonality and second-order statistics technique within PCA algorithms, however, may not be applied to the biological systems studied. Extracting and characterizing the most informative features of the biological signals, however, require higher-order statistics.</p> <p>Results</p> <p>ICA is one of the unsupervised algorithms that can extract higher-order statistical structures from data and has been applied to DNA microarray gene expression data analysis. We performed FastICA method on DNA microarray gene expression data from Alzheimer's disease (AD) hippocampal tissue samples and consequential gene clustering. Experimental results showed that the ICA method can improve the clustering results of AD samples and identify significant genes. More than 50 significant genes with high expression levels in severe AD were extracted, representing immunity-related protein, metal-related protein, membrane protein, lipoprotein, neuropeptide, cytoskeleton protein, cellular binding protein, and ribosomal protein. Within the aforementioned categories, our method also found 37 significant genes with low expression levels. Moreover, it is worth noting that some oncogenes and phosphorylation-related proteins are expressed in low levels. In comparison to the PCA and support vector machine recursive feature elimination (SVM-RFE) methods, which are widely used in microarray data analysis, ICA can identify more AD-related genes. Furthermore, we have validated and identified many genes that are associated with AD pathogenesis.</p> <p>Conclusion</p> <p>We demonstrated that ICA exploits higher-order statistics to identify gene expression profiles as linear combinations of elementary expression patterns that lead to the construction of potential AD-related pathogenic pathways. Our computing results also validated that the ICA model outperformed PCA and the SVM-RFE method. This report shows that ICA as a microarray data analysis tool can help us to elucidate the molecular taxonomy of AD and other multifactorial and polygenic complex diseases.</p