The interface between intrapreneurship, innovation and IT governance

The purpose of this conceptual paper is to examine the links, as reported in the international literature, between intrapreneurship, innovativeness and IT governance within medium to large organizations. A cross disciplinary literature review was conducted and yielded a theoretical framework for identifying and understanding the critical elements underpinning and driving innovation and intrapreneurship performance and their relationship with key aspects of IT governance within organizations.<br /

Pervasive limitations : innovating with ambient intelligence (AmI) technologies and restricted absorptive capacity in Australian SME manufacturers

The last 25 years have seen rapid increases in the number and sophistication of technological and process innovations in large manufacturers, producing dramatic improvements in productivity and efficiency. However, smaller manufacturers&rsquo; adoption of such innovations has been uneven. Ambient Intelligence (AmI) technologies are being positioned as the next performance and productivity enhancing purchase for manufacturers. This paper defines and gives examples of AmI technologies in current use, summarises AmI technologies of potential interest to small and medium enterprise (SME) manufacturers, and identifies potential impacts of restricted absorptive capacity in SMEs on the adoption of AmI technologies. Comparing two SME manufacturers, one from Germany and one from Australia illustrates a potential application of generic AmI technology based business solutions to a range of SME manufacturers.<br /

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

Mammalian cells respond to DNA double-strand breaks (DSBs) by recruiting DNA repair and cell-cycle checkpoint proteins to such sites. Central to these DNA damage response (DDR) events is the DNA damage mediator protein MDC1. MDC1 interacts with several DDR proteins, including the MRE11–RAD50–NBS1 (MRN) complex. Here, we show that MDC1 is phosphorylated on a cluster of conserved repeat motifs by casein kinase 2 (CK2). Moreover, we establish that this phosphorylation of MDC1 promotes direct, phosphorylation-dependent interactions with NBS1 in a manner that requires the closely apposed FHA and twin BRCT domains in the amino terminus of NBS1. Finally, we show that these CK2-targeted motifs in MDC1 are required to mediate NBS1 association with chromatin-flanking sites of unrepaired DSBs. These findings provide a molecular explanation for the MDC1–MRN interaction and yield insights into how MDC1 coordinates the focal assembly and activation of several DDR factors in response to DNA damage

The construction and evaluation of a word pronunciation test for grades four, five, and six

Thesis (Ed.M.)--Boston Universit

An optimal ALMA image of the Hubble Ultra Deep Field in the era of JWST: obscured star formation and the cosmic far-infrared background

We combine archival ALMA data targeting the Hubble Ultra Deep Field (HUDF) to produce the deepest currently attainable 1-mm maps of this key, extragalactic survey field. Combining all existing data in Band 6, our deepest map covers 4.2arcmin^2, with a beamsize of 1.49"x1.07" at an effective frequency of 243GHz (1.23mm). It reaches an rms of 4.6uJy/beam, with 1.5arcmin^2 below 9.0uJy/beam, an improvement of >5% over the best previously published map and 50% improvement in some regions. We also make a wider, but shallower map, covering 25.4arcmin^2. We detect 45 galaxies in the deep map down to 3.6sigma, including 10 more 1-mm sources than previously detected. 38 of these galaxies have a JWST ID from the JADES NIRCam imaging and the new sources are typically faint and red. A stacking analysis on the positions of ALMA-undetected JADES galaxies yields detections for z<4 and stellar masses from 10^(8.4) to 10^(10.4)Msun, extracting 10% of additional stacked signal from our map compared to previous analyses. Detected sources and stacking contribute (10.0+/-0.5)Jy/deg^2 of the cosmic infrared background (CIB) at 1.23mm. Although this is short of the (uncertain) background level of about 20Jy/deg^2, after taking into account intrinsic fluctuations in the CIB, our measurement is consistent with the background if the HUDF is a mild (~2sigma) negative fluctuation. This suggests that within the HUDF, JWST may have detected essentially all of the galaxies that contribute to the CIB. Our stacking analysis predicts that the field contains around 60 additional galaxies with 1.23mm flux densities averaging around 15uJy, and over 300 galaxies at the few uJy level. However, the contribution of these fainter more modestly-obscured objects to the background is small, and converging, as anticipated from the now well-established strong correlation between galaxy stellar mass and obscured star formation.Comment: Submitted to MNRA

Tailoring the magnetic properties of Fe asymmetric nanodots

Asymmetric dots as a function of their geometry have been investigated using three-dimensional (3D) object oriented micromagnetic framework (OOMMF) code. The effect of shape asymmetry of the disk on coercivity and remanence is studied. Angular dependence of the remanence and coercivity is also addressed. Asymmetric dots are found to reverse their magnetization by nucleation and propagation of a vortex, when the field is applied parallel to the direction of asymmetry. However, complex reversal modes appear when the angle at which the external field is applied is varied, leading to a non monotonic behavior of the coercivity and remanence.Comment: 5 pages, 7 figure

The relationship between gastric emptying, plasma cholecystokinin, and peptide YY in critically ill patients

© 2007 Nguyen et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background Cholecystokinin (CCK) and peptide YY (PYY) are released in response to intestinal nutrients and play an important physiological role in regulation of gastric emptying (GE). Plasma CCK and PYY concentrations are elevated in critically ill patients, particularly in those with a history of feed intolerance. This study aimed to evaluate the relationship between CCK and PYY concentrations and GE in critical illness. Methods GE of 100 mL of Ensure® meal (106 kcal, 21% fat) was measured using a 13C-octanoate breath test in 39 mechanically ventilated, critically ill patients (24 males; 55.8 ± 2.7 years old). Breath samples for 13CO2 levels were collected over the course of 4 hours, and the GE coefficient (GEC) (normal = 3.2 to 3.8) was calculated. Measurements of plasma CCK, PYY, and glucose concentrations were obtained immediately before and at 60 and 120 minutes after administration of Ensure. Results GE was delayed in 64% (25/39) of the patients. Baseline plasma CCK (8.5 ± 1.0 versus 6.1 ± 0.4 pmol/L; P = 0.045) and PYY (22.8 ± 2.2 versus 15.6 ± 1.3 pmol/L; P = 0.03) concentrations were higher in patients with delayed GE and were inversely correlated with GEC (CCK: r = -0.33, P = 0.04, and PYY: r = -0.36, P = 0.02). After gastric Ensure, while both plasma CCK (P = 0.03) and PYY (P = 0.02) concentrations were higher in patients with delayed GE, there was a direct relationship between the rise in plasma CCK (r = 0.40, P = 0.01) and PYY (r = 0.42, P < 0.01) from baseline at 60 minutes after the meal and the GEC. Conclusion In critical illness, there is a complex interaction between plasma CCK, PYY, and GE. Whilst plasma CCK and PYY correlated moderately with impaired GE, the pathogenetic role of these gut hormones in delayed GE requires further evaluation with specific antagonists.Nam Q Nguyen, Robert J Fraser, Laura K Bryant, Marianne J Chapman, Judith Wishart, Richard H Holloway, Ross Butler, and Michael Horowit

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.

PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRDM9-bound loci do not become recombination hotspots. To explore factors that affect binding and subsequent recombination outcomes, we mapped human PRDM9 binding sites in a transfected human cell line and measured PRDM9-induced histone modifications. These data reveal varied DNA-binding modalities of PRDM9. We also find that human PRDM9 frequently binds promoters, despite their low recombination rates, and it can activate expression of a small number of genes including CTCFL and VCX. Furthermore, we identify specific sequence motifs that predict consistent, localized meiotic recombination suppression around a subset of PRDM9 binding sites. These motifs strongly associate with KRAB-ZNF protein binding, TRIM28 recruitment, and specific histone modifications. Finally, we demonstrate that, in addition to binding DNA, PRDM9's zinc fingers also mediate its multimerization, and we show that a pair of highly diverged alleles preferentially form homo-multimers