A Study on the Right to Use Rural Homestead: Taking Changchun City and the Surrounding Area as the Example

Based on the analysis and comparison of the data collected from a field survey on the status quo of the right to use rural homestead in Changchun City and the surrounding area, this paper not only reflects on the history and theory of the right to use rural homestead in China, but also proposes solutions and suggestions in accordance with the reality towards the development of rural areas in China

Remote creation of strong and coherent emissions in air with two-color ultrafast laser pulses

We experimentally demonstrate generation of strong narrow-bandwidth emissions with excellent coherent properties at ~391 nm and ~428 nm from molecular ions of nitrogen inside a femtosecond filament in air by an orthogonally polarized two-color driver field (i. e., 800 nm laser pulse and its second harmonic). The durations of the coherent emissions at 391 nm and 428 nm are measured to be ~2.4 ps and ~7.8 ps respectively, both of which are much longer than the duration of the pump and its second harmonic pulses. Furthermore, the measured temporal decay characteristics of the excited molecular systems suggest an "instantaneous" population inversion mechanism that may be achieved in molecular nitrogen ions at an ultrafast time scale comparable to the 800 nm pump pulse.Comment: 19 pages, 4 figure

Identification of the chemical components of ethanol extract of Chenopodium ambrosioides and evaluation of their in vitro antioxidant and anti tumor activities

Purpose: To determine the characteristic chemical components of the ethanol extract of Chenopodium ambrosioides and evaluate their antioxidant and anti-tumor effects in vitro. Methods: The plant powder (5 g) was extracted with 1 L of 80 % ethanol at room temperature for 45 min, and then placed at 60 oC at varying microwave power and duration to obtain optimal extraction conditions. Characteristic chemical components were detected using ultra-high performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS/MS). Kaempferitrin was isolated from the 80 % ethanol extract using a D101 macroporous resin column, and its content was assessed by high performance liquid chromatography (HPLC). The antioxidant effect of kaempferitrin was evaluated by its ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) radicals, while its anti-proliferation activity in human liver cancer cells SMMC-7721 was determined using cell counting kit-8 (CCK-8) reagent. Results: Three characteristic components of ethanol extract of C. ambrosioides were obtained, namely, kaempferitrin, kaempferol-3-O-apigenin-7-O-rhamnoside and kaempferol-3-O-acetylapigenin-7-O-rhamnoside. Kaempferitrin was shown to possess strong DPPH radical and moderate ABTS radical scavenging activities. Kaempferitrin significantly inhibited the proliferation of SMMC-7721 cells at doses of 4 and 8 μg/mL, with half-maximal concentration (IC50) of 0.38 μM (p < 0.05). Conclusion: Kaempferitrin extracted from C. ambrosioides has antioxidant and anti-tumor activities. The results reported here indicate that C. ambrosioides may have potential use in herbal medicine practice

Development and validation of a patient-specific model to predict postoperative SIRS in older patients: A two-center study

IntroductionPostoperative systemic inflammatory response syndrome (SIRS) is common in surgical patients especially in older patients, and the geriatric population with SIRS is more susceptible to sepsis, MODS, and even death. We aimed to develop and validate a model for predicting postoperative SIRS in older patients.MethodsPatients aged ≥65 years who underwent general anesthesia in two centers of Third Affiliated Hospital of Sun Yat-sen University from January 2015 to September 2020 were included. The cohort was divided into training and validation cohorts. A simple nomogram was developed to predict the postoperative SIRS in the training cohort using two logistic regression models and the brute force algorithm. The discriminative performance of this model was determined by area under the receiver operating characteristics curve (AUC). The external validity of the nomogram was assessed in the validation cohort.ResultsA total of 5,904 patients spanning from January 2015 to December 2019 were enrolled in the training cohort and 1,105 patients from January 2020 to September 2020 comprised the temporal validation cohort, in which incidence rates of postoperative SIRS were 24.6 and 20.2%, respectively. Six feature variables were identified as valuable predictors to construct the nomogram, with high AUCs (0.800 [0.787, 0.813] and 0.822 [0.790, 0.854]) and relatively balanced sensitivity (0.718 and 0.739) as well as specificity (0.718 and 0.729) in both training and validation cohorts. An online risk calculator was established for clinical application.ConclusionWe developed a patient-specific model that may assist in predicting postoperative SIRS among the aged patients

Gain dynamics of a free-space nitrogen laser pumped by circularly polarized femtosecond laser pulses

We experimentally demonstrate ultrafast dynamic of generation of a strong 337-nm nitrogen laser by injecting an external seed pulse into a femtosecond laser filament pumped by a circularly polarized laser pulse. In the pump-probe scheme, it is revealed that the population inversion between the excited and ground states of N2 for the free-space 337-nm laser is firstly built up on the timescale of several picoseconds, followed by a relatively slow decay on the timescale of tens of picoseconds, depending on the nitrogen gas pressure. By measuring the intensities of 337-nm signal from nitrogen gas mixed with different concentrations of oxygen gas, it is also found that oxygen molecules have a significant quenching effect on the nitrogen laser signal. Our experimental observations agree with the picture of electron-impact excitation.Comment: 9 pages, 5 figure

Harmonic-seeded remote laser emissions in N2-Ar, N2-Xe and N2-Ne mixtures: a comparative study

We report on the investigation on harmonic-seeded remote laser emissions at 391 nm wavelength from strong-field ionized nitrogen molecules in three different gas mixtures, i.e., N2-Ar, N2-Xe and N2-Ne. We observed a decrease in the remote laser intensity in the N2-Xe mixture because of the decreased clamped intensity in the filament; whereas in the N2-Ne mixture, the remote laser intensity slightly increases because of the increased clamped intensity within the filament. Remarkably, although the clamped intensity in the filament remains nearly unchanged in the N2-Ar mixture because of the similar ionization potentials of N2 and Ar, a significant enhancement of the lasing emission is realized in the N2-Ar mixture. The enhancement is attributed to the stronger third harmonic seed, and longer gain medium due to the extended filament.Comment: 10 pages, 5 figure

Association between intraoperative dexmedetomidine and all-cause mortality and recurrence after laparoscopic resection of colorectal cancer: Follow-up analysis of a previous randomized controlled trial

BackgroundDexmedetomidine (DEX) has been widely applied in the anesthesia and sedation of patients with oncological diseases. However, the potential effect of DEX on tumor metastasis remains contradictory. This study follows up on patients who received intraoperative DEX during laparoscopic resection of colorectal cancer as part of a previous clinical trial, examining their outcomes 5 years later.MethodsBetween June 2015 and December 2015, 60 patients undergoing laparoscopic colorectal resection were randomly assigned to the DEX and control groups. The DEX group received an initial loading dose of 1μ/kg before surgery, followed by a continuous infusion of 0.3μg/kg/h during the operation and the Control group received an equivalent volume of saline. A 5-year follow-up analysis was conducted to evaluate the overall survival, disease-free survival, and tumor recurrence.ResultsThe follow-up analysis included 55 of the 60 patients. The DEX group included 28 patients, while the control group included 27 patients. Baseline characteristics were comparable between the two groups, except for vascular and/or neural invasion of the tumor in the DEX group (9/28 vs. 0/27, p = 0.002). We did not observe a statistically significant benefit but rather a trend toward an increase in overall survival and disease-free survival in the DEX group, 1-year overall survival (96.4% vs. 88.9%, p = 0.282), 2-year overall survival (89.3% vs. 74.1%, p = 0.144), 3-year overall survival (89.3% vs. 70.4%, p = 0.08), and 5-year overall survival (78.6% vs. 59.3%, p = 0.121). The total rates of mortality and recurrence between the two groups were comparable (8/28 vs. 11/27, p = 0.343).ConclusionAdministration of DEX during laparoscopic resection of colorectal cancer had a nonsignificant trend toward improved overall survival and disease-free survival.Clinical Trial Registrationhttp://www.chictr.org.cn/, identifier ChiCTRIOR-15006518

Dynamics and Control of Typical Orbits around Saturn

This paper investigates the dynamics of some typical orbits around Saturn, including sun-synchronous orbits, repeating ground track orbits, frozen orbits, and stationary orbits, and corresponding control methods mainly based on the mean element theory. The leading terms of Saturn’s aspheric gravitational field, J2 and J4 terms, are used when designing the orbits around Saturn. Two control methods of sun-synchronous orbits, including initial inclination-biased method and periodic inclination-biased method, are used to damp the local time drift at the descending node, which is caused by solar gravitation and atmospheric drag. The compensation of semimajor axis and maneuver period to maintain the recursive feature of repeating ground orbits are calculated. While only J2 and J3 terms are taken into account, we examine the argument that the perigee of frozen orbits around Saturn should be 270 deg to promise meaningful eccentricity. The perturbations of inclination and eccentricity of stationary orbits due to solar gravitation and solar radiation pressure are presented. Meanwhile, the preliminary control strategies of inclination perturbation and eccentricity perturbation are naturally introduced

Changes of different connexins and mitochondrial dynamins in early acute kidney injury after liver transplantation

Objective To explore the potential relationship between different connexins and mitochondrial dynamic imbalance and mitochondrial injury in early acute kidney injury after liver transplantation. Methods 24 healthy specific pathogen-free （SPF） SD male rats were randomly divided into the sham operation group （sham group， n = 6）， and 2-， 4- and 8-h reperfusion liver transplantation groups （M2， M4 and M8 groups， n = 6 each）. In the sham group， open surgery alone was performed for vessel separation. In the M2， M4 and M8 groups， orthotopic liver transplantation was conducted. Renal function and renal pathological examination were determined. The expression levels of connexin 32 （Cx32）， Cx43， dynamin-related protein 1 （Drp1）， mitofusin-1 （Mfn1）， Mfn2， optic atrophy 1 （Opa1） and C/EBP homologous protein （CHOP）， an endoplasmic reticulum stress-related protein， were detected in each group. The morphological changes of mitochondria were observed under electron microscope. Results Compared with the sham group， the pathological score of kidney tissue injury in the M2 group was increased （P < 0.01）， and gradually increased over reperfusion time， and reached the peak in the M8 group （P < 0.001）. However， serum creatinine （SCr） and blood urea nitrogen （BUN） levels were up-regulated only in the M8 group （P < 0.001， P < 0.05）. Compared with the sham group， Cx32 level was increased in the M2 group （P < 0.01）， Cx43 level was increased in the M4 group （P < 0.001）， and reached the peak in the M8 group （both P < 0.001）. Compared with the sham group， the expression levels of Drp1， Mfn1， Mfn2 and OPA1 were up-regulated in the M2 group （all P < 0.001）. Under electron microscope， mitochondrial injury， mitochondrial autophagy， lysosomal autophagy and slightly swollen rough endoplasmic reticulum were observed in the M2 group. The degree of mitochondrial injury was aggravated over reperfusion time during liver transplantation. Mitochondrial autophagy and endoplasmic reticulum - mitochondria contact sites were observed in the M2， M4 and M8 groups. Conclusions Kidney pathological injury and mitochondrial injury occur early after autogenous orthotopic liver transplantation in SD rats. The diagnosis of kidney injury by SCr and BUN levels can be delayed. The expression level of Cx32 in the renal tissues is up-regulated early after liver transplantation. Active mitochondrial division and fusion can be seen， suggesting that the transmission of injury signals by Cx32 is associated with mitochondrial injury and mitochondrial dynamic imbalance， which may be an important mechanism of early acute kidney injury after liver transplantation