Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Application of Geodesign Techniques for Ecological Engineered Landscaping of Urban River Wetlands: A Case Study of Yuhangtang River

Although geodesign techniques have been studied and developed worldwide, there is still a lack of in-depth application of geodesign workflows for redesigning urban river wetlands with characteristics of ecologically engineered landscaping (EEL). The study mainly aims at putting forward a proper approach in the methodological foundation for EEL practices in river wetlands. A typical EEL-oriented project of river restoration in Hangzhou, China, was conducted in this study. Based on in-situ geodata and tools within QGIS, individual geological factors analysis, with the hierarchical analysis method (AHP) and ecological vulnerability evaluation (EVE), was conducted by experts’ voting and the weighted linear combination (WLC) method. Analysis of hydrological-related factors proceeded. This GIS-based analysis with expert knowledge provided comprehensive redesign solutions for the redesign project, i.e., restoration of the riverbed, spatial restoration in the horizontal and vertical dimensions, and integration with the multifunctional design. Detailed three-dimensional models for design practices were developed to present redesigned topology and space accordingly. Terrain, inundation, and visibility analysis proceeded with parametric mapping programs within Grasshopper to check the feasibility. The adapted geodesign-based workflow in the study also applies to the site analysis, sustainable assessment and landscape planning for urban wetlands EEL projects

Application of Geodesign Techniques for Ecological Engineered Landscaping of Urban River Wetlands: A Case Study of Yuhangtang River

Although geodesign techniques have been studied and developed worldwide, there is still a lack of in-depth application of geodesign workflows for redesigning urban river wetlands with characteristics of ecologically engineered landscaping (EEL). The study mainly aims at putting forward a proper approach in the methodological foundation for EEL practices in river wetlands. A typical EEL-oriented project of river restoration in Hangzhou, China, was conducted in this study. Based on in-situ geodata and tools within QGIS, individual geological factors analysis, with the hierarchical analysis method (AHP) and ecological vulnerability evaluation (EVE), was conducted by experts’ voting and the weighted linear combination (WLC) method. Analysis of hydrological-related factors proceeded. This GIS-based analysis with expert knowledge provided comprehensive redesign solutions for the redesign project, i.e., restoration of the riverbed, spatial restoration in the horizontal and vertical dimensions, and integration with the multifunctional design. Detailed three-dimensional models for design practices were developed to present redesigned topology and space accordingly. Terrain, inundation, and visibility analysis proceeded with parametric mapping programs within Grasshopper to check the feasibility. The adapted geodesign-based workflow in the study also applies to the site analysis, sustainable assessment and landscape planning for urban wetlands EEL projects

One‐year status of hepatic venous pressure gradient measurement from 85 hospitals in China

Abstract Aims Surveys and research on the applications of the hepatic venous pressure gradient (HVPG) are important for understanding the current status and future development of this technology in China. This article aimed to investigate the status of hepatic venous pressure gradient measurement in China in 2022. Methods We investigated the overall status of HVPG technology in China—including hospital distribution, hospital level, annual number of cases, catheters used, average cost, indications, and current challenges by using online questionnaire. By counting the number and percentages of cases of these results, we hope to clarify the current status of HVPG measurements in China. Results According to the survey, 85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces. A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022, of which 2813 cases (56.4%) were measured alone. The average cost of HVPG measurement was 5646.8 ± 2327.9 CNY. Of the clinical teams who performed the measurements (sometimes multiple per hospital), 94.3% (82/87) used the balloon method, and the majority of the teams (72.4%, 63/87) used embolectomy catheters. Conclusions This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this technology. It is still necessary to continue promoting and popularizing this technology in the future