81 research outputs found

    Relationship Between Duration of Type 2 Diabetes and Effectiveness of DPP-4 Inhibitor Versus Sulfonylurea as Add-on Therapy: A Post Hoc Analysis

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    <p><strong>Article full text</strong></p> <p><br> The full text of this article can be found <a href="https://link.springer.com/article/10.1007/s13300-017-0276-1"><b>here</b>.</a><br> <br> <strong>Provide enhanced digital features for this article</strong><br> If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact <u>[email protected]</u>.<br> <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.<br> <br> Other enhanced features include, but are not limited to:<br> • Slide decks<br> • Videos and animations<br> • Audio abstracts<br> • Audio slides<u></u></p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p

    Gene expressions in monocytes of obese subjects.

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    <p>Data shown are means ± SEM.</p>***<p><i>P</i><0.001 obese compared with lean controls.</p

    miR-146b-5p inhibition prevents the anti-inflammatory action of globular adiponectin.

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    <p>(<b>A</b>) TNFα RNA levels and soluble TNFα protein levels, (<b>B</b>) IRAK3 RNA and protein levels, (<b>C</b>) m- and iROS production, (<b>D</b>) IRS1 RNA and protein levels in THP-1 cells exposed to 10 µg/ml globular adiponectin with (n = 4) or without (n = 6) inhibition of miR-146b-5p. Data shown are means ± SEM. <sup>*</sup><i>P</i><0.05, <sup>**</sup><i>P</i><0.01 and <sup>***</sup><i>P</i><0.001 compared with THP-1 cells exposed to 10 µg/ml globular adiponectin without miR-146b-5p inhibition. Abbreviations: iROS, intracellular ROS; mROS, mitochondrial ROS; ROS, reactive oxygen species.</p

    miR-146b-5p expression is decreased in monocytes of obese subjects and is regulated by globular adiponectin.

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    <p>(<b>A</b>) miR-146b-5p expression levels in isolated monocytes from 14 lean controls and 21 obese subjects as determined by qRT-PCR analysis. Data are expressed as means. <sup>**</sup><i>P</i><0.01 obese compared with lean controls. miR-146b-5p expression levels determined by qRT-PCR in THP-1 cells exposed to (<b>B</b>) 1 or 10 µg/ml globular adiponectin for 24 h (n = 6), and (<b>C</b>) 5.5 mM D-glucose and 9.5 mM D-mannitol (osmotic control) or 15 mM D-glucose for 24 h (n = 6). Data shown are means ± SEM. <sup>*</sup><i>P</i><0.05 compared with THP-1 cells exposed to 10 µg/ml globular adiponectin.</p

    Comparison of the beta-cell function and the insulin sensitivity between women with an impaired fasting glucose (IFG) and women with an impaired glucose tolerance (IGT) postpartum.

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    <p>Comparison of the beta-cell function and the insulin sensitivity between women with an impaired fasting glucose (IFG) and women with an impaired glucose tolerance (IGT) postpartum.</p

    Comparison of the characteristics between women with a normal OGTT and women with glucose intolerance postpartum.

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    <p>Comparison of the characteristics between women with a normal OGTT and women with glucose intolerance postpartum.</p

    Comparison of the characteristics between women who received an OGTT postpartum and women who failed to attend the scheduled OGTT post-partum.

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    <p>Comparison of the characteristics between women who received an OGTT postpartum and women who failed to attend the scheduled OGTT post-partum.</p

    Comparison of characteristics between women with an impaired fasting glucose (IFG) and women with an impaired glucose tolerance (IGT) postpartum.

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    <p>Comparison of characteristics between women with an impaired fasting glucose (IFG) and women with an impaired glucose tolerance (IGT) postpartum.</p
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