Improving WIC Retention in Vermont: Beneficiary attitudes toward co-location in medical homes

Introduction: The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is a national program aimed at improving the nutrition and health of pregnant women and children. Those eligible for Vermont WIC include anyone pregnant or with children under 5 that has an income below 185% of federal poverty level or is enrolled in Vermont Medicaid. WIC has been shown to improve birth outcomes1, breast feeding rates2, infant growth and development, and consumption of important nutrients. Those enrolled in WIC report high levels of satisfaction Despite the benefits of WIC, retention rates of eligible families remain low. Studies have shown that mandatory bi-annual recertification appointments pose logistical problems. Rescheduling missed appointments and long waiting times at the WIC offices were also barriers. Other states have found that integration of WIC recertification appointments with the family’s primary care medical visits may improve retention. A limited scale co-localization of WIC and the medical home in Vermont showed some promise.https://scholarworks.uvm.edu/comphp_gallery/1213/thumbnail.jp

Clustering Under Perturbation Stability in Near-Linear Time

We consider the problem of center-based clustering in low-dimensional Euclidean spaces under the perturbation stability assumption. An instance is ?-stable if the underlying optimal clustering continues to remain optimal even when all pairwise distances are arbitrarily perturbed by a factor of at most ?. Our main contribution is in presenting efficient exact algorithms for ?-stable clustering instances whose running times depend near-linearly on the size of the data set when ? ? 2 + ?3. For k-center and k-means problems, our algorithms also achieve polynomial dependence on the number of clusters, k, when ? ? 2 + ?3 + ? for any constant ? > 0 in any fixed dimension. For k-median, our algorithms have polynomial dependence on k for ? > 5 in any fixed dimension; and for ? ? 2 + ?3 in two dimensions. Our algorithms are simple, and only require applying techniques such as local search or dynamic programming to a suitably modified metric space, combined with careful choice of data structures

Diffuse Ionized Gas in Simulations of Multiphase, Star-Forming Galactic Disks

It has been hypothesized that photons from young, massive star clusters are responsible for maintaining the ionization of diffuse warm ionized gas seen in both the Milky Way and other disk galaxies. For a theoretical investigation of the warm ionized medium (WIM), it is crucial to solve radiation transfer equations where the ISM and clusters are modeled self-consistently. To this end, we employ a Solar neighborhood model of TIGRESS, a magnetohydrodynamic simulation of the multiphase, star-forming ISM, and post-process the simulation with an adaptive ray tracing method to transfer UV radiation from star clusters. We find that the WIM volume filling factor is highly variable, and sensitive to the rate of ionizing photon production and ISM structure. The mean WIM volume filling factor rises to ~0.15 at |z|~1 kpc. Approximately half of ionizing photons are absorbed by gas and half by dust; the cumulative ionizing photon escape fraction is 1.1%. Our time-averaged synthetic H$\alpha$ line profile matches WHAM observations on the redshifted (outflowing) side, but has insufficient intensity on the blueshifted side. Our simulation matches the Dickey-Lockman neutral density profile well, but only a small fraction of snapshots have high-altitude WIM density consistent with Reynolds Layer estimates. We compute a clumping correction factor C = /sqrt~0.2 that is remarkably constant with distance from the midplane and time; this can be used to improve estimates of ionized gas mass and mean electron density from observed H$\alpha$ surface brightness profiles in edge-on galaxies.Comment: Accepted to ApJ; 31 pages, 17 figure

Tenodesis Grasp Emulator: Kinematic Assessment of Wrist-Driven Orthotic Control

Wrist-driven orthotics have been designed to assist people with C6-7 spinal cord injury, however, the kinematic constraint imposed by such a control strategy can impede mobility and lead to abnormal body motion. This study characterizes body compensation using the novel Tenodesis Grasp Emulator, an adaptor orthotic that allows for the investigation of tenodesis grasping in subjects with unimpaired hand function. Subjects perform a series of grasp-and-release tasks in order to compare normal (test control) and constrained wrist-driven modes, showing significant compensation as a result of the constraint. A motor-augmented mode is also compared against traditional wrist-driven operation, to explore the potential role of hybrid human-robot control. We find that both the passive wrist-driven and motor-augmented modes fulfill different roles throughout various tasks tested. Thus, we conclude that a flexible control scheme that can alter intervention based on the task at hand holds the potential to reduce compensation in future work.Comment: 7 pages, 11 figures, submitted to International Conference on Robotics and Automation (ICRA) 2022. Video Supplement: https://youtu.be/NIgKg5R3Ro

A Scientific Communication Mentoring Intervention Benefits Diverse Mentees With Language Variety Related Discomfort

We studied social-psychological effects over time of a faculty-mentor workshop intervention that addressed attitudes associated with language variety and their impact on scientific communication (SC) skill development of PhD and postdoctoral STEM research trainees (N = 274). Six months after their mentors attended the workshop, all mentees had significant gains in productivity in speaking tasks. In particular, mentees with high language discomfort rated their quality of communication with their mentor and their enthusiasm about communicating more highly (p \u3c .05 for both measures), compared to mentees with low language discomfort. In addition, mentees raised speaking nonstandardized varieties of English reported significant reductions in discomfort related to language use (p = .003), compared to mentees raised speaking standardized English. We conclude that training mentors to understand and respond to language diversity and development results in multiple beneficial outcomes for mentees, including the amelioration of language-variety related discomfort in the research environment

N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice.

The nucleus is a critical subcellular compartment for the pathogenesis of polyglutamine disorders, including Huntington's disease (HD). Recent studies suggest the first 17-amino-acid domain (N17) of mutant huntingtin (mHTT) mediates its nuclear exclusion in cultured cells. Here, we test whether N17 could be a molecular determinant of nuclear mHTT pathogenesis in vivo. BAC transgenic mice expressing mHTT lacking the N17 domain (BACHD-ΔN17) show dramatically accelerated mHTT pathology exclusively in the nucleus, which is associated with HD-like transcriptionopathy. Interestingly, BACHD-ΔN17 mice manifest more overt disease-like phenotypes than the original BACHD mice, including body weight loss, movement deficits, robust striatal neuron loss, and neuroinflammation. Mechanistically, N17 is necessary for nuclear exclusion of small mHTT fragments that are part of nuclear pathology in HD. Together, our study suggests that N17 modifies nuclear pathogenesis and disease severity in HD mice by regulating subcellular localization of known nuclear pathogenic mHTT species