THE EFFECT OF INNOVATION STRATEGY ON POST-M&A INNOVATION PERFORMANCE: AN EVIDENCE FROM PHARMACEUTICAL INDUSTRY

M&A is a popular strategy for pharmaceutical industry due to high R&D risk and costs. Prior research related to post-M&A performance mainly focused on the financial and technology resource perspectives. This study aims to provide a new perspective of innovation strategy which is inspired by the research of March (1991), who noted the difference between exploration and exploitation. Moreover, we build the bridge between M&A and innovation strategy by applying the resource-based view theory. We argue that the acquirer’s exploration strategy will negatively influence the post-M&A innovation performance and the innovation strategy similarity between the acquirer and the target is beneficial for future innovation. Furthermore, we hypothesize that there is a negatively moderating effect caused by the acquirer’s exploration strategy on the effect of innovation strategy similarity. On the basis of 89 M&A deals in the pharmaceutical industry, our empirical results suggest two important findings. First, post- M&A innovation performance is influenced by acquirer’s innovation strategy, more specifically, acquirer’s exploration is harmful for post-M&A innovation. Second, the similarity effect is moderated by acquirer’s innovation strategy. Precisely, acquirer’s exploration will diminish the positive effect of similarity

A Retrospective Cohort Study Comparing Stroke Recurrence Rate in Ischemic Stroke Patients With and Without Acupuncture Treatment.

Little was known about the effects of acupuncture on stroke recurrence. The aim of this study is to investigate whether ischemic stroke patients receiving acupuncture treatment have a decreased risk of stroke recurrence. A retrospective cohort study of 30,058 newly diagnosed cases of ischemic stroke in 2000 to 2004 was conducted based on the claims of Taiwan National Health Insurance Research Database. The use of acupuncture treatment and stroke recurrence were identified during the follow-up period from 2000 to 2009. This study compared the risk of stroke recurrence between ischemic stroke cohorts with and without acupuncture treatment by calculating adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of acupuncture associated with stroke recurrence in the Cox proportional hazard model. The stroke recurrence rate per 1000 person-years decreased from 71.4 without to 69.9 with acupuncture treatment (P < 0.001). Acupuncture treatment was associated with reduced risk of stroke recurrence (HR 0.88; 95% CI 0.84-0.91). The acupuncture effect was noted in patients with or without medical treatment for stroke prevention but its impact decreased with aging of stroke patients. Compared with stroke patients without acupuncture treatment and medication therapy, the hazard ratios of stroke recurrence for those had medication therapy only, acupuncture only, and both were 0.42 (95% CI 0.38-0.46), 0.50 (95% CI 0.43-0.57), and 0.39 (95% CI 0.35-0.43), respectively. This study raises the possibility that acupuncture might be effective in lowering stroke recurrence rate even in those on medications for stroke prevention. Results suggest the need of prospective sham-controlled and randomized trials to establish the efficacy of acupuncture in preventing stroke

Renal and survival benefits of seventeen prescribed Chinese herbal medicines against oxidative-inflammatory stress in systemic lupus erythematosus patients with chronic kidney disease: a real-world longitudinal study

Background: Systemic lupus erythematosus (SLE) significantly links to LN, a type of CKD with high mortality despite modern Western treatments. About 70% of SLE patients develop LN, and 30% advance to end-stage renal disease (ESRD). Concerns about glucocorticoid side effects and LN worsening due to oxidative stress prompt alternative treatment searches. In Taiwan, over 85% of SLE patients opt for complementary methods, especially Chinese herbal medicine (CHM). We pinpointed seventeen CHMs for SLE (PRCHMSLE) with antioxidative and anti-inflammatory properties from national health insurance data (2000–2017). Our primary aim was to assess their impact on renal and survival outcomes in SLE patients progressing to CKD (SLE-CKD), with a secondary focus on the risks of hospitalization and hyperkalemia.Methods: We established a propensity-matched cohort of 1,188 patients with SLE-CKD, comprising 594 PRCHMSLE users and 594 nonusers. We employed Cox proportional hazards models and restricted mean survival time (RMST) analyses to assess the renal and survival outcomes of PRCHMSLE users. Moreover, we performed pooling and network analyses, specifically focusing on the renal effects linked to PRCHMSLE.Results: PRCHMSLE use was associated with decreased adjusted hazard ratios for ESRD (0.45; 95% confidence interval, 0.25–0.79, p = 0.006), all-cause mortality (0.56; 0.43–0.75, p < 0.0001), non-cardiovascular mortality (0.56; 0.42–0.75, p < 0.0001), and hospitalization (0.72; 0.52–0.96, p = 0.009). Hyperkalemia risk did not increase. Significant differences in RMST were observed: 0.57 years (95% confidence interval, 0.19–0.95, p = 0.004) for ESRD, 1.22 years (0.63–1.82, p < 0.0001) for all-cause mortality, and 1.21 years (0.62–1.80, p < 0.0001) for non-cardiovascular mortality, favoring PRCHMSLE use. Notably renoprotective PRCHMSLE included Gan-Lu-Ying, Anemarrhena asphodeloides Bunge [Asparagaceae; Rhizoma Anemarrhenae] (Zhi-Mu), Rehmannia glutinosa (Gaertn.) DC. [Orobanchaceae; Radix Rehmanniae] (Sheng-Di-Huang), Jia-Wei-Xiao-Yao-San, and Paeonia suffruticosa Andr. [Paeoniaceae; Cortex Moutan] (Mu-Dan-Pi). Network analysis highlighted primary treatment strategies with central components like Liu-Wei-Di-Huang-Wan, Paeonia suffruticosa Andr. [Paeoniaceae; Cortex Moutan] (Mu-Dan-Pi), Anemarrhena asphodeloides Bunge [Asparagaceae; Rhizoma Anemarrhenae] (Zhi-Mu), Rehmannia glutinosa (Gaertn.) DC. [Orobanchaceae; Radix Rehmanniae] (Sheng-Di-Huang), and Zhi-Bai-Di-Huang-Wan.Conclusion: This work underscores the pronounced renal and survival benefits associated with the seventeen PRCHMSLE in the treatment of SLE-CKD, concurrently mitigating the risks of hospitalization and hyperkalemia. This highlights their potential as alternative treatment options for individuals with this condition

The linkages with fires, vegetation composition and human activity in response to climate changes in the Chinese Loess Plateau during the Holocene

Holocene paleo-records of the Chinese Loess Plateau loess-soil profiles were used to reconstruct wildfire patterns and landscape evolution. We examine black carbon and charcoal influx, combined with the Magnetic susceptibility, delta C-13 values of soil organic matter, pollen counts and other paleo-environmental proxies to discuss interactions with biomass-climate during the Holocene. The history of fires from the charcoal and black carbon (BC, char and soot) influx at the two sites demonstrates a transition from climate-controlled low amplitude variations with peaks during the Early and Middle Holocene (11-3.1kyearsB.P.) to higher amplitude variability in fire occurrence decoupled from climate and tied to human activities during the Late Holocene (3.1-0kyearsB.P.). The difference in fire patterns was attributed to regional effective moisture and human land use over the entre Loess Plateau; meanwhile, fire activities observed during the Holocene are consistent with variations in vegetation composition inferred from delta C-13 values in soil organic matter, pollen counts, and paleoclimate proxies. Regional wildfires rarely occurred on the desert steppe dominated by a weedy C-3 taxon (Artemisia, Compositae, and Chenopodiaceae dominated)during the late glacial period. A limited biomass would not meet fire propagation in the extreme colder and drier environment of the Loess Plateau during those periods, though. As the climate became ameliorated during the early Holocene, there was an increasing biomass and a sufficient contribution do to high fuel accumulation from C-4 taxon (Gramineae). As the middle Holocene progressed toward warmer and wetter conditions, fire events were less frequent on the steppe and forest-steppe (e.g. expansion of trees C-3,C- Quercus, Corylus) of the Loess Plateau. Subsequently, the number of local and regional fire events have largely increased with the colder and drier climate conditions (e.g. expansion of C-3 weedy), which have been decoupling with intensive anthropogenic burning for farming since the past 3kyr. These data suggests that the regional fire patterns vary strongly along environmental gradients in the effective moisture and regional fuel availability as well as the spatial and temporal distributions of Neolithic burning practices over the Loess Plateau in response to the weakening East Asian monsoon during the Holocene

Neuroimmunological effects of omega-3 fatty acids on migraine: a review

Migraine is a highly prevalent disease worldwide, imposing enormous clinical and economic burdens on individuals and societies. Current treatments exhibit limited efficacy and acceptability, highlighting the need for more effective and safety prophylactic approaches, including the use of nutraceuticals for migraine treatment. Migraine involves interactions within the central and peripheral nervous systems, with significant activation and sensitization of the trigeminovascular system (TVS) in pain generation and transmission. The condition is influenced by genetic predispositions and environmental factors, leading to altered sensory processing. The neuroinflammatory response is increasingly recognized as a key event underpinning the pathophysiology of migraine, involving a complex neuro-glio-vascular interplay. This interplay is partially mediated by neuropeptides such as calcitonin gene receptor peptide (CGRP), pituitary adenylate cyclase activating polypeptide (PACAP) and/or cortical spreading depression (CSD) and involves oxidative stress, mitochondrial dysfunction, nucleotide-binding domain-like receptor family pyrin domain containing-3 (NLRP3) inflammasome formation, activated microglia, and reactive astrocytes. Omega-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), crucial for the nervous system, mediate various physiological functions. Omega-3 PUFAs offer cardiovascular, neurological, and psychiatric benefits due to their potent anti-inflammatory, anti-nociceptive, antioxidant, and neuromodulatory properties, which modulate neuroinflammation, neurogenic inflammation, pain transmission, enhance mitochondrial stability, and mood regulation. Moreover, specialized pro-resolving mediators (SPMs), a class of PUFA-derived lipid mediators, regulate pro-inflammatory and resolution pathways, playing significant anti-inflammatory and neurological roles, which in turn may be beneficial in alleviating the symptomatology of migraine. Omega-3 PUFAs impact various neurobiological pathways and have demonstrated a lack of major adverse events, underscoring their multifaceted approach and safety in migraine management. Although not all omega-3 PUFAs trials have shown beneficial in reducing the symptomatology of migraine, further research is needed to fully establish their clinical efficacy and understand the precise molecular mechanisms underlying the effects of omega-3 PUFAs and PUFA-derived lipid mediators, SPMs on migraine pathophysiology and progression. This review highlights their potential in modulating brain functions, such as neuroimmunological effects, and suggests their promise as candidates for effective migraine prophylaxis

幼稚園教室綠化對學童注意力之影響

本研究目的為探討教室內環境的綠化與兒童的直接注意力是否相關，並討論在不同課程種類及不同專注力的高低下，室內環境綠化與兒童注意力的關係。研究地點為幼稚園教室，樣本為12位幼稚園學童，將學童的注意力行為分類依程度不同分為六類，並使用「間歇記錄法」評量其上課的注意力，以10秒觀察，5秒記錄的方式，觀察其注意力行為，共得3749次有效次數。本研究以「教室環境綠化有無」為自變項，「兒童注意力行為」為依變項，經列聯表及卡方檢定，測試其關聯性。統計結果顯示，p值達顯著水準，表示環境的綠化與兒童注意力之間是相關，綠化環境有助於兒童上課的注意力的提升。在不同的課程種類下，則發現綠化環境有助於兒童上課的注意力的提升有程度上的差異。而在不同的個人特質下，專注度較高的兒童，在綠化環境下注意力的強化效果也較專注度低的兒童來得好。總機而言，結果均說明室內綠化環境有助於兒童上課的注意力表現。The purpose of this study is to test the relatonship between child's direct attention with the planting vs. non-planting classroom. Controlling of different kinds of children's attention characters. Six testing weeks were arranged in a kindergarten. Week 1 and 2 were the pilot study period. During week 3 and 4, the classroom was arranged without plant. While during week 5 and 6, the classroom was arranged with plants. There are 12 children in this classroom. The children's attentive was categorized into 6 levels. The “Interval Recording Method ”was applied with 10 seconds observation and 5 seconds recording periods. Finall, 3749 observation sections were recorded during these 6 weeks. The planting was used as the independent variable and the child's attention behavior were used as independent variable for crosstabulation analysis. Result shows planting classroom increase children's attention level. The increasing attention effects various with different kinds of classes. Children with better attention characters have better benefit during the plating section

Predicting Suicidality in Late-Life Depression by 3D Convolutional Neural Network and Cross-Sample Entropy Analysis of Resting-State fMRI

BACKGROUND: Predicting suicide is a pressing issue among older adults; however, predicting its risk is difficult. Capitalizing on the recent development of machine learning, considerable progress has been made in predicting complex behavior such as suicide. As depression remained the strongest risk for suicide, we aimed to apply deep learning algorithms to identify suicidality in a group with late-life depression (LLD). METHODS: We enrolled 83 patients with LLD, 35 of which were non-suicidal and 48 were suicidal, including 26 with only suicidal ideation and 22 with past suicide attempts, for resting-state functional magnetic resonance imaging (MRI). Cross-sample entropy (CSE) analysis was conducted to examine the complexity of MRI signals among brain regions. Three-dimensional (3D) convolutional neural networks (CNNs) were used, and the classification accuracy in each brain region was averaged to predict suicidality after sixfold cross-validation. RESULTS: We found brain regions with a mean accuracy above 75% to predict suicidality located mostly in default mode, fronto-parietal, and cingulo-opercular resting-state networks. The models with right amygdala and left caudate provided the most reliable accuracy in all cross-validation folds, indicating their neurobiological importance in late-life suicide. CONCLUSION: Combining CSE analysis and the 3D CNN, several brain regions were found to be associated with suicidality

Prokaryotic assemblages and metagenomes in pelagic zones of the South China Sea

Background: Prokaryotic microbes, the most abundant organisms in the ocean, are remarkably diverse. Despite numerous studies of marine prokaryotes, the zonation of their communities in pelagic zones has been poorly delineated. By exploiting the persistent stratification of the South China Sea (SCS), we performed a 2-year, large spatial scale (10, 100, 1000, and 3000 m) survey, which included a pilot study in 2006 and comprehensive sampling in 2007, to investigate the biological zonation of bacteria and archaea using 16S rRNA tag and shotgun metagenome sequencing. Results: Alphaproteobacteria dominated the bacterial community in the surface SCS, where the abundance of Betaproteobacteria was seemingly associated with climatic activity. Gammaproteobacteria thrived in the deep SCS, where a noticeable amount of Cyanobacteria were also detected. Marine Groups II and III Euryarchaeota were predominant in the archaeal communities in the surface and deep SCS, respectively. Bacterial diversity was higher than archaeal diversity at all sampling depths in the SCS, and peaked at mid-depths, agreeing with the diversity pattern found in global water columns. Metagenomic analysis not only showed differential %GC values and genome sizes between the surface and deep SCS, but also demonstrated depth-dependent metabolic potentials, such as cobalamin biosynthesis at 10 m, osmoregulation at 100 m, signal transduction at 1000 m, and plasmid and phage replication at 3000 m. When compared with other oceans, urease at 10 m and both exonuclease and permease at 3000 m were more abundant in the SCS. Finally, enriched genes associated with nutrient assimilation in the sea surface and transposase in the deep-sea metagenomes exemplified the functional zonation in global oceans. Conclusions: Prokaryotic communities in the SCS stratified with depth, with maximal bacterial diversity at mid-depth, in accordance with global water columns. The SCS had functional zonation among depths and endemically enriched metabolic potentials at the study site, in contrast to other oceans