CentralNet: a Multilayer Approach for Multimodal Fusion

This paper proposes a novel multimodal fusion approach, aiming to produce best possible decisions by integrating information coming from multiple media. While most of the past multimodal approaches either work by projecting the features of different modalities into the same space, or by coordinating the representations of each modality through the use of constraints, our approach borrows from both visions. More specifically, assuming each modality can be processed by a separated deep convolutional network, allowing to take decisions independently from each modality, we introduce a central network linking the modality specific networks. This central network not only provides a common feature embedding but also regularizes the modality specific networks through the use of multi-task learning. The proposed approach is validated on 4 different computer vision tasks on which it consistently improves the accuracy of existing multimodal fusion approaches

Evidence for Environmentally Dependent Cluster Disruption in M83

Using multi-wavelength imaging from the Wide Field Camera 3 on the Hubble Space Telescope we study the stellar cluster populations of two adjacent fields in the nearby face-on spiral galaxy, M83. The observations cover the galactic centre and reach out to ~6 kpc, thereby spanning a large range of environmental conditions, ideal for testing empirical laws of cluster disruption. The clusters are selected by visual inspection to be centrally concentrated, symmetric, and resolved on the images. We find that a large fraction of objects detected by automated algorithms (e.g. SExtractor or Daofind) are not clusters, but rather are associations. These are likely to disperse into the field on timescales of tens of Myr due to their lower stellar densities and not due to gas expulsion (i.e. they were never gravitationally bound). We split the sample into two discrete fields (inner and outer regions of the galaxy) and search for evidence of environmentally dependent cluster disruption. Colour-colour diagrams of the clusters, when compared to simple stellar population models, already indicate that a much larger fraction of the clusters in the outer field are older by tens of Myr than in the inner field. This impression is quantified by estimating each cluster's properties (age, mass, and extinction) and comparing the age/mass distributions between the two fields. Our results are inconsistent with "universal" age and mass distributions of clusters, and instead show that the ambient environment strongly affects the observed populations.Comment: 6 pages, 3 figures, MNRAS in pres

Growth of wildtype and mutant E. coli strains in minimal media for optimal production of nucleic acids for preparing labeled nucleotides

Since RNAs lie at the center of most cellular processes, there is a need for synthesizing large amounts of RNAs made from stable isotope-labeled nucleotides to advance the study of their structure and dynamics by nuclear magnetic resonance (NMR) spectroscopy. A particularly effective means of obtaining labeled nucleotides is to harvest these nucleotides from bacteria grown in defined minimal media supplemented with 15NH4Cl and various carbon sources. Given the high cost of carbon precursors required for labeling nucleic acids for NMR studies, it becomes important to evaluate the optimal growth for commonly used strains under standard minimal media conditions. Such information is lacking. In this study, we characterize the growth for Escherichia coli strains K12, K10zwf, and DL323 in three minimal media with isotopic-labeled carbon sources of acetate, glycerol, and glycerol combined with formate. Of the three media, the LeMaster-Richards and the Studier media outperform the commonly used M9 media and both support optimal growth of E. coli for the production of nucleotides. However, the growth of all three E. coli strains in acetate is reduced almost twofold compared to growth in glycerol. Analysis of the metabolic pathway and previous gene array studies help to explain this differential growth in glycerol and acetate. These studies should benefit efforts to make selective 13C-15N isotopic-labeled nucleotides for synthesizing biologically important RNAs

The Hanabi Challenge: A New Frontier for AI Research

From the early days of computing, games have been important testbeds for studying how well machines can do sophisticated decision making. In recent years, machine learning has made dramatic advances with artificial agents reaching superhuman performance in challenge domains like Go, Atari, and some variants of poker. As with their predecessors of chess, checkers, and backgammon, these game domains have driven research by providing sophisticated yet well-defined challenges for artificial intelligence practitioners. We continue this tradition by proposing the game of Hanabi as a new challenge domain with novel problems that arise from its combination of purely cooperative gameplay with two to five players and imperfect information. In particular, we argue that Hanabi elevates reasoning about the beliefs and intentions of other agents to the foreground. We believe developing novel techniques for such theory of mind reasoning will not only be crucial for success in Hanabi, but also in broader collaborative efforts, especially those with human partners. To facilitate future research, we introduce the open-source Hanabi Learning Environment, propose an experimental framework for the research community to evaluate algorithmic advances, and assess the performance of current state-of-the-art techniques.Comment: 32 pages, 5 figures, In Press (Artificial Intelligence

Nonequilibrium brittle fracture propagation: Steady state, oscillations and intermittency

A minimal model is constructed for two-dimensional fracture propagation. The heterogeneous process zone is presumed to suppress stress relaxation rate, leading to non-quasistatic behavior. Using the Yoffe solution, I construct and solve a dynamical equation for the tip stress. I discuss a generic tip velocity response to local stress and find that noise-free propagation is either at steady state or oscillatory, depending only on one material parameter. Noise gives rise to intermittency and quasi-periodicity. The theory explains the velocity oscillations and the complicated behavior seen in polymeric and amorphous brittle materials. I suggest experimental verifications and new connections between velocity measurements and material properties.Comment: To appear in Phys. Rev. Lett., 6 pages, self-contained TeX file, 3 postscript figures upon request from author at [email protected] or [email protected], http://cnls-www.lanl.gov/homepages/rafi/rafindex.htm

Evolution of stellar structure in the Small Magellanic Cloud

The projected distribution of stars in the Small Magellanic Cloud (SMC) from the Magellanic Clouds Photometric Survey is analysed. Stars of different ages are selected via criteria based on V magnitude and V-I colour, and the degree of `grouping' as a function of age is studied. We quantify the degree of structure using the two-point correlation function and a method based on the Minimum Spanning Tree and find that the overall structure of the SMC is evolving from a high degree of sub-structure at young ages (~10 Myr) to a smooth radial density profile. This transition is gradual and at ~75 Myr the distribution is statistically indistinguishable from the background SMC distribution. This time-scale corresponds to approximately the dynamical crossing time of stars in the SMC. The spatial positions of the star clusters in the SMC show a similar evolution of spatial distribution with age. Our analysis suggests that stars form with a high degree of (fractal) sub-structure, probably imprinted by the turbulent nature of the gas from which they form, which is erased by random motions in the galactic potential on a time-scale of a galactic crossing time.Comment: Updated to match final journal styl

The M33 Globular Cluster System with PAndAS Data: The Last Outer Halo Cluster?

We use CFHT/MegaCam data to search for outer halo star clusters in M33 as part of the Pan-Andromeda Archaeological Survey (PAndAS). This work extends previous studies out to a projected radius of 50 kpc and covers over 40 square degrees. We find only one new unambiguous star cluster in addition to the five previously known in the M33 outer halo (10 kpc <= r <= 50 kpc). Although we identify 2440 cluster candidates of various degrees of confidence from our objective image search procedure, almost all of these are likely background contaminants, mostly faint unresolved galaxies. We measure the luminosity, color and structural parameters of the new cluster in addition to the five previously-known outer halo clusters. At a projected radius of 22 kpc, the new cluster is slightly smaller, fainter and redder than all but one of the other outer halo clusters, and has g' ~ 19.9, (g'-i') ~ 0.6, concentration parameter c ~ 1.0, a core radius r_c ~ 3.5 pc, and a half-light radius r_h ~ 5.5 pc. For M33 to have so few outer halo clusters compared to M31 suggests either tidal stripping of M33's outer halo clusters by M31, or a very different, much calmer accretion history of M33.Comment: 37 pages, 9 figures. Accepted by the Astrophysical Journa

Cord bilirubin levels as a predictive marker for neonatal hyperbilirubinemia: A prospective study

Background: Hyperbilirubinemia is the most common medical problem in newborn infants. Early discharge is recommended but hospital readmission is a cause of concern among clinicians. This in turn carries a risk of delayed recognition of significant hyperbilirubinemia. Objective: A cross-sectional analytical study was done to evaluate the predictive value of cord bilirubin level for identifying term and near-term neonates for subsequent hyperbilirubinemia. Materials and Methods: Cord bilirubin levels at birth and subsequently serum bilirubin levels at 72 h were assessed in 100 neonates. The cutoff value was estimated beyond which there was significant hyperbilirubinemia. Results: The cutoff value of cord bilirubin &gt;2.02 mg/dl had sensitivity and specificity of 87.5-70.8%, respectively, with positive predictive value of 0.39 and negative predictive value of 0.965 for subsequent hyperbilirubinemia. Conclusion: The cutoff value of cord bilirubin level estimated is 2.02 mg/dl can be used to predict significant neonatal hyperbilirubinemia

Using H-alpha Morphology and Surface Brightness Fluctuations to Age-Date Star Clusters in M83

We use new WFC3 observations of the nearby grand design spiral galaxy M83 to develop two independent methods for estimating the ages of young star clusters. The first method uses the physical extent and morphology of Halpha emission to estimate the ages of clusters younger than tau ~10 Myr. It is based on the simple premise that the gas in very young (tau < few Myr) clusters is largely coincident with the cluster stars, is in a small, ring-like structure surrounding the stars in slightly older clusters (e.g., tau ~5 Myr), and is in a larger ring-like bubble for still older clusters (i.e., ~5-10 Myr). The second method is based on an observed relation between pixel-to-pixel flux variations within clusters and their ages. This method relies on the fact that the brightest individual stars in a cluster are most prominent at ages around 10 Myr, and fall below the detection limit (i.e., M_V < -3.5) for ages older than about 100 Myr. These two methods are the basis for a new morphological classification system which can be used to estimate the ages of star clusters based on their appearance. We compare previous age estimates of clusters in M83 determined from fitting UBVI Halpha measurements using predictions from stellar evolutionary models with our new morphological categories and find good agreement at the ~95% level. The scatter within categories is ~0.1 dex in log tau for young clusters (10 Myr) clusters. A by-product of this study is the identification of 22 "single-star" HII regions in M83, with central stars having ages ~4 Myr.Comment: 33 pages, 10 figures, 3 tables; published in March Ap