16 research outputs found
Membrana amniótica e pericárdio canino como curativos biológicos na preparação do leito receptor para enxertia cutânea autógena
Coding of facial expressions of pain in the laboratory mouse
Facial expression is widely used as a measure of pain in infants; whether nonhuman animals display such pain expressions has never been systematically assessed. We developed the mouse grimace scale (MGS), a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain. This measure of spontaneously emitted pain may provide insight into the subjective pain experience of mice.Paroxysmal Cerebral Disorder
Glycosidases and acid-invertase activities are not correlated with Phaseolus hypocotyl growth
Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice
Migraine is a highly prevalent, disabling and complex episodic brain disorder whose pathogenesis is poorly understood, due in part to the lack of valid animal models. Here we report behavioral evidence of hallmark migraine features, photophobia and unilateral head pain, in transgenic knock-in mice bearing human familial hemiplegic migraine, type 1 (FHM-1) gain-of-function missense mutations (R192Q or S218L) in the Cacna1a gene encoding the C