Metabolic Syndrome Predicts New Onset of Chronic Kidney Disease in 5,829 Patients With Type 2 Diabetes: A 5-year prospective analysis of the Hong Kong Diabetes Registry

OBJECTIVE—Type 2 diabetes is the leading cause of end-stage renal disease worldwide. Aside from hyperglycemia and hypertension, other metabolic factors may determine renal outcome. We examined risk associations of metabolic syndrome with new onset of chronic kidney disease (CKD) in 5,829 Chinese patients with type 2 diabetes enrolled between 1995 and 2005

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

The Dreamland: Isthmus - Interactive performance via the use of experimental AR (Augmented Reality) and escape game methodology

References: Giang, C., Chevalier, M., Negrini, L., Peleg, R., Bonnet, E., Piatti, A., & Mondada, F. (2020). Exploring escape games as a teaching tool in educational robotics. In Educational Robotics in the Context of the Maker Movement (pp. 95-106). Springer International Publishing. Hu, R., Wang, C., Zhang, T., Nguyen, T., Shapoval, V., & Zhai, L. (2021). Applying augmented reality (AR) technologies in theatrical performances in theme parks: A transcendent experience perspective. Tourism Management Perspectives, 40, 100889. Javornik, A. (2016). Augmented reality: Research agenda for studying the impact of its media characteristics on consumer behaviour. Journal of Retailing and Consumer Services, 30, 252-261. Reviews: https://glamadelaide.com.au/fringe-review-the-dreamland-isthmus/ https://adelaidefringe.com.au/fringefeed/critic_reviews/2025Dream Diver

Sickness absence in private sector establishments in Singapore

Singapore Medical Journal389379-383SIMJ

Pulmonary function in healthy Chinese, Malay and Indian adults in Singapore.

Annals of the Academy of Medicine Singapore226878-88

Low birth weight in relation to parental occupations - A population-based registry in Singapore (1994-1998)

10.1016/j.ntt.2003.10.009Neurotoxicology and Teratology262285-290NETE

Parental occupations and other risk factors associated with nonchromosomal single, chromosomal single, and multiple birth defects: A population-based study in Singapore from 1994 to 1998

10.1067/mob.2003.73American Journal of Obstetrics and Gynecology1882425-433AJOG

Prevalence of birth defects and parental work in Singapore live births from 1994 and 1998: A population-based study

10.1093/occmed/52.6.325Occupational Medicine526325-331OCME

A population-based study on the association between parental occupations and some common birth defects in Singapore (1994-1998)

10.1097/01.jom.0000137720.84374.41Journal of Occupational and Environmental Medicine469916-923JOEM