2 research outputs found
Iron Oxide@PEDOT-Based Recyclable Photothermal Nanoparticles with Poly(vinylpyrrolidone) Sulfobetaines for Rapid and Effective Antibacterial Activity
Growing microbial resistance that
renders antibiotic treatment
vulnerable has emerged, attracting a great deal of interest in the
need to develop alternative antimicrobial treatments. To contribute
to this effort, we report magnetic iron oxide (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles (NPs) coated with catechol-conjugated poly(vinylpyrrolidone)
sulfobetaines (C-PVPS). This negatively charged Fe<sub>3</sub>O<sub>4</sub>@C-PVPS is subsequently encapsulated by poly(3,4-ethylenedioxythiophene)
(PEDOT) following a layer-by-layer (LBL) self-assembly method. The
obtained Fe<sub>3</sub>O<sub>4</sub>@C-PVPS:PEDOT nanoparticles appear
to be novel NIR-irradiated photothermal agents that can achieve effective
bacterial killing and are reusable after isolation of the used particles
using external magnetic fields. The recyclable Fe<sub>3</sub>O<sub>4</sub>@C-PVPS:PEDOT NPs exhibit a high efficiency in converting
photothermal heat for rapid antibacterial effects against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. In this study, antibacterial tests for repeated uses maintained
almost 100% antibacterial efficiency during three cycles and provided
rapid and effective killing of 99% Gram-positive and -negative bacteria
within 5 min of near-infrared (NIR) light exposure. The core–shell
nanoparticles (Fe<sub>3</sub>O<sub>4</sub>@C-PVPS:PEDOT) exhibit the
required stability, and their paramagnetic nature means that they
rapidly convert photothermal heat sufficient for use as NIR-irradiated
antibacterial photothermal sterilizing agents
Light Controllable Surface Coating for Effective Photothermal Killing of Bacteria
Although the electronic properties
of conducting films have been widely explored in optoelectronic fields,
the optical absorption abilities of surface-coated films for photothermal
conversion have been relatively less explored in the production of
antibacterial coatings. Here, we present catechol-conjugated poly(vinylpyrrolidone)
sulfobetaine (PVPS) and polyaniline (PANI) tightly linked by ionic
interaction (PVPS:PANI) as a novel photothermal antibacterial agent
for surface coating, which can absorb broadband near-infrared (NIR)
light. Taking advantage of the NIR light absorption, this coating
film can release eminent photothermal heat for the rapid killing of
surface bacteria. The NIR light triggers a sharp rise in photothermal
heat, providing the rapid and effective killing of 99.9% of the Gram-positive
and -negative bacteria tested within 3 min of NIR light exposure when
used at the concentration of 1 mg/mL. Although considerable progress
has been made in the design of antibacterial coatings, the user control
of NIR-irradiated rapid photothermal destruction of surface bacteria
holds increasing attention beyond the traditional boundaries of typical
antibacterial surfaces