995 research outputs found
Finding diamonds in the rough: Targeted Sub-threshold Search for Strongly-lensed Gravitational-wave Events
Strong gravitational lensing of gravitational waves can produce duplicate
signals separated in time with different amplitudes. We consider the case in
which strong lensing produces identifiable gravitational-wave events and weaker
sub-threshold signals hidden in the noise background. We present a search
method for the sub-threshold signals using reduced template banks targeting
specific confirmed gravitational-wave events. We apply the method to all events
from Advanced LIGO's first and second observing run O1/O2. Using GW150914 as an
example, we show that the method effectively reduces the noise background and
raises the significance of (near-) sub-threshold triggers. In the case of
GW150914, we can improve the sensitive distance by . Finally,
we present the top possible lensed candidates for O1/O2 gravitational-wave
events that passed our nominal significance threshold of False-Alarm-Rate days
TESLA-X: An effective method to search for sub-threshold lensed gravitational waves with a targeted population model
Strong gravitational lensing can produce copies of gravitational-wave signals
from the same source with the same waveform morphologies but different
amplitudes and arrival times. Some of these strongly-lensed gravitational-wave
signals can be demagnified and become sub-threshold. We present TESLA-X, an
enhanced approach to the original GstLAL-based TargetEd Subthreshold Lensing
seArch (TESLA) method, for improving the detection efficiency of these
potential sub-threshold lensed signals. TESLA-X utilizes lensed injections to
generate a targeted population model and a targeted template bank. We compare
the performance of a full template bank search, TESLA, and TESLA-X methods via
a simulation campaign, and demonstrate the performance of TESLA-X in recovering
lensed injections, particularly targeting a mock event. Our results show that
the TESLA-X method achieves a maximum of higher search sensitivity
compared to the TESLA method within the sub-threshold regime, presenting a step
towards detecting the first lensed gravitational wave. TESLA-X will be employed
for the LIGO-Virgo-KAGRA's collaboration-wide analysis to search for lensing
signatures in the fourth observing run
Theory of Dynamic Stripe Induced Superconductivity
Since the recently reported giant isotope effect on T* [1] could be
consistently explained within an anharmonic spin-charge-phonon interaction
model, we consider here the role played by stripe formation on the
superconducting properties within the same model. This is a two-component
scenario and we recast its basic elements into a BCS effective Hamiltonian. We
find that the stripe formation is vital to high-Tc superconductivity since it
provides the glue between the two components to enhance Tc to the unexpectedly
large values observed experimentally.Comment: 7 pages, 2 figure
Ohta-Jasnow-Kawasaki Approximation for Nonconserved Coarsening under Shear
We analytically study coarsening dynamics in a system with nonconserved
scalar order parameter, when a uniform time-independent shear flow is present.
We use an anisotropic version of the Ohta-Jasnow-Kawasaki approximation to
calculate the growth exponents in two and three dimensions: for d=3 the
exponents we find are the same as expected on the basis of simple scaling
arguments, that is 3/2 in the flow direction and 1/2 in all the other
directions, while for d=2 we find an unusual behavior, in that the domains
experience an unlimited narrowing for very large times and a nontrivial
dynamical scaling appears. In addition, we consider the case where an
oscillatory shear is applied to a two-dimensional system, finding in this case
a standard t^1/2 growth, modulated by periodic oscillations. We support our
two-dimensional results by means of numerical simulations and we propose to
test our predictions by experiments on twisted nematic liquid crystals.Comment: 25 RevTeX pages, 7 EPS figures. To be published in Phys. Rev.
A Compensatory Mutation Provides Resistance to Disparate HIV Fusion Inhibitor Peptides and Enhances Membrane Fusion
Fusion inhibitors are a class of antiretroviral drugs used to prevent entry of HIV into host cells. Many of the fusion inhibitors being developed, including the drug enfuvirtide, are peptides designed to competitively inhibit the viral fusion protein gp41. With the emergence of drug resistance, there is an increased need for effective and unique alternatives within this class of antivirals. One such alternative is a class of cyclic, cationic, antimicrobial peptides known as θ-defensins, which are produced by many non-human primates and exhibit broad-spectrum antiviral and antibacterial activity. Currently, the θ-defensin analog RC-101 is being developed as a microbicide due to its specific antiviral activity, lack of toxicity to cells and tissues, and safety in animals. Understanding potential RC-101 resistance, and how resistance to other fusion inhibitors affects RC-101 susceptibility, is critical for future development. In previous studies, we identified a mutant, R5-tropic virus that had evolved partial resistance to RC-101 during in vitro selection. Here, we report that a secondary mutation in gp41 was found to restore replicative fitness, membrane fusion, and the rate of viral entry, which were compromised by an initial mutation providing partial RC-101 resistance. Interestingly, we show that RC-101 is effective against two enfuvirtide-resistant mutants, demonstrating the clinical importance of RC-101 as a unique fusion inhibitor. These findings both expand our understanding of HIV drug-resistance to diverse peptide fusion inhibitors and emphasize the significance of compensatory gp41 mutations. © 2013 Wood et al
Laboratory Diagnosis of SARS
The virologic test results of 415 patients with severe acute respiratory syndrome (SARS) were examined. The peak detection rate for SARS-associated coronavirus occurred at week 2 after illness onset for respiratory specimens, at weeks 2 to 3 for stool or rectal swab specimens, and at week 4 for urine specimens. The latest stool sample that was positive by reverse transcription–polymerase chain reaction (RT-PCR) was collected on day 75 while the patient was receiving intensive care. Tracheal aspirate and stool samples had a higher diagnostic yield (RT-PCR average positive rate for first 2 weeks: 66.7% and 56.5%, respectively). Pooled throat and nasal swabs, rectal swab, nasal swab, throat swab, and nasopharyngeal aspirate specimens provided a moderate yield (29.7%–40.0%), whereas throat washing and urine specimens showed a lower yield (17.3% and 4.5%). The collection procedures for stool and pooled nasal and throat swab specimens were the least likely to transmit infection, and the combination gave the highest yield for coronavirus detection by RT-PCR. Positive virologic test results in patient groups were associated with mechanical ventilation or death (p < 0.001), suggesting a correlation between viral load and disease severity
Digital Signal Processing
Contains reports on twelve research projects.U. S. Navy - Office of Naval Research (Contract N00014-75-C-0951)National Science Foundation (Grant ENG76-24117)National Aeronautics and Space Administration (Grant NSG-5157)Joint Services Electronics Program (Contract DAABO7-76-C-1400)U.S. Navy-Office of Naval Research (Contract N00014-77-C-0196)Woods Hole Oceanographic InstitutionU. S. Navy - Office of Naval Research (Contract N00014-75-C-0852)Department of Ocean Engineering, M.I.T.National Science Foundation subcontract to Grant GX 41962 to Woods Hole Oceanographic Institutio
Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 study
Lower socioeconomic status (SES) is strongly associated with an increased risk of morbidity and premature mortality, but it is not known if the same is true for telomere length, a marker often used to assess biological ageing. The West of Scotland Twenty-07 Study was used to investigate this and consists of three cohorts aged approximately 35 (N = 775), 55 (N = 866) and 75 years (N = 544) at the time of telomere length measurement. Four sets of measurements of SES were investigated: those collected contemporaneously with telomere length assessment, educational markers, SES in childhood and SES over the preceding twenty years. We found mixed evidence for an association between SES and telomere length. In 35-year-olds, many of the education and childhood SES measures were associated with telomere length, i.e. those in poorer circumstances had shorter telomeres, as was intergenerational social mobility, but not accumulated disadvantage. A crude estimate showed that, at the same chronological age, social renters, for example, were nine years (biologically) older than home owners. No consistent associations were apparent in those aged 55 or 75. There is evidence of an association between SES and telomere length, but only in younger adults and most strongly using education and childhood SES measures. These results may reflect that childhood is a sensitive period for telomere attrition. The cohort differences are possibly the result of survival bias suppressing the SES-telomere association; cohort effects with regard different experiences of SES; or telomere possibly being a less effective marker of biological ageing at older ages
Digital Signal Processing
Contains a research summary and reports on fifteen research projects.National Science Foundation FellowshipJoint Services Electronics Program (Contract DAAG29-78-C-0020)National Science Foundation (Grant ENG76-24117)U.S. Navy - Office of Naval Research (Contract N00014-75-C-0951)National Science Foundation (Grant ENG76-24117)Schlumberger-Doll Research Center FellowshipHertz Foundation FellowshipNational Aeronautics and Space Administration (Grant NSG-5157)U.S. Navy - Office of Naval Research (Contract N00014-77-C-0196
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