Generalized characteristics of photo-elastic birefringence in polymer strip waveguides

This work investigates the material birefringence in a polymer strip waveguide which originates from thermal stress during the fabrication process. The stress is estimated through a comprehensive numerical study based on a realistic finite element model. The characteristics of birefringence are obtained in a generalized form and expressed by an empirical formula, which is applicable to various polymer materials. The developed formula can be employed to specify the photo-elastic birefringence of a polymer strip channel only by knowing the birefringence in its planar film. This will eliminate the necessity of extensive numerical analysis of thermal stress in such polymer waveguides, and accordingly help the management of stress-induced effects efficiently

High-sensitivity magnetic sensor based on the evanescent scattering by a magnetorheological film

We present a simple concept to implement a magnetic sensor that uses evanescent scattering by a suspended magnetorheological (MR) film above a planar waveguide. The soft MR film embedded with ferromagnetic particles is to induce scattering on the evanescent field of a planar waveguide at a proximity distance. This distance can be controlled precisely by a magnetic field. Consequently, the waveguide output power changes in response to the magnetic intensity. Two sensor prototypes of different film thicknesses were designed and tested showing a trade-off between the sensitivity and dynamic sensing range. A maximum sensitivity of ∼2.62dB/mT was obtained. Compared to optical micro-electromechanical systems, the presented sensors feature a simple design, easy fabrication, low cost, and the potential for large-scale production and miniaturization to be integrated into portable devices

Sensing Characteristics of Fiber Fabry-Perot Sensors Based on Polymer Materials

A simple optic-fiber Fabry-Perot (FP) sensing technique was proposed and experimentally investigated by using polymer material to connect the ends of two singlemode fibers. Four different polymer materials (benzocyclobutene (BCB), UV88 (Relentless, China), Loctite3525 (HenKel, Germany), and NOA68 (Norland, USA)) filling the FP cavity were used to comparatively study the sensing performance of temperature, strain and refractive index. The result shows that the FP sensor with BCB has excellent repeatability with good linear response to temperature in a wide range from room temperature to 250 ◦C, which is much larger than that of other three materials (<90 ◦C), while UV88 with a cost of less than 1/10 of the other three polymer materials has the best sensitivity to strain and temperature. In addition, the FP sensor was firstly applied to measure ultraviolet (UV) light ntensity. The test results demonstrate that the proposed FP sensor structure has a good linear response and repeatability to UV intensity for all four polymer materials, and Loctite3525 has the highest sensitivity (0.0087 nm/(mw/cm2)) and the best repeatability among the four polymer materials

U-shape panda polarization-maintaining microfiber sensor coated with graphene oxide for relative humidity measurement

A new U-shape panda polarization-maintaining fiber (PPMF) based microfiber interferometer coated with graphene oxide (GO) film was proposed and experimentally demonstrated for relative humidity (RH) sensing. Experimental results show that the U-shape sensor has refractive index (RI) sensitivity of 1692.5nm/RIU in the RI range of 1.33 when the diameter of the taper waist is 10.08 µm. The surface of the U-shape sensor was then modified chemically and coated with a thin layer of GO film (59.64nm) for RH detection and the sensitivity is proportional to RH: as RH increases from 30% to 98%, the sensitivity increases from 0.111 to 0.361 nm/%RH and the response time is 0.28 s. In addition, the cross sensitivity to temperature, stability, reproducibility, and response/recovery time of the RH sensor were studied in detail. The proposed U-shape fiber RH sensor has advantage of high sensitivity, good reproducibility and fast response (0.28 s), which has potential application in areas requiring dynamic measurement of RH variations such as industrial product fabrication process control and breath state monitoring

Fine Mapping of the NRG1 Hirschsprung's Disease Locus

The primary pathology of Hirschsprung's disease (HSCR, colon aganglionosis) is the absence of ganglia in variable lengths of the hindgut, resulting in functional obstruction. HSCR is attributed to a failure of migration of the enteric ganglion precursors along the developing gut. RET is a key regulator of the development of the enteric nervous system (ENS) and the major HSCR-causing gene. Yet the reduced penetrance of RET DNA HSCR-associated variants together with the phenotypic variability suggest the involvement of additional genes in the disease. Through a genome-wide association study, we uncovered a ∼350 kb HSCR-associated region encompassing part of the neuregulin-1 gene (NRG1). To identify the causal NRG1 variants contributing to HSCR, we genotyped 243 SNPs variants on 343 ethnic Chinese HSCR patients and 359 controls. Genotype analysis coupled with imputation narrowed down the HSCR-associated region to 21 kb, with four of the most associated SNPs (rs10088313, rs10094655, rs4624987, and rs3884552) mapping to the NRG1 promoter. We investigated whether there was correlation between the genotype at the rs10088313 locus and the amount of NRG1 expressed in human gut tissues (40 patients and 21 controls) and found differences in expression as a function of genotype. We also found significant differences in NRG1 expression levels between diseased and control individuals bearing the same rs10088313 risk genotype. This indicates that the effects of NRG1 common variants are likely to depend on other alleles or epigenetic factors present in the patients and would account for the variability in the genetic predisposition to HSCR

RET Mutational Spectrum in Hirschsprung Disease: Evaluation of 601 Chinese Patients

Rare (RVs) and common variants of the RET gene contribute to Hirschsprung disease (HSCR; congenital aganglionosis). While RET common variants are strongly associated with the commonest manifestation of the disease (males; short-segment aganglionosis; sporadic), rare coding sequence (CDS) variants are more frequently found in the lesser common and more severe forms of the disease (females; long/total colonic aganglionosis; familial)

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals &lt;1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

Silicon Oxynitride Optical Waveguide Ring Resonator Utilizing a Two-Mode Interferometer Structure

Silicon oxynitride (SiOxNy, SiON) optical waveguide ring resonator, in which a two-mode interferometer is used to replace the directional coupler in a conventional ring resonator, has been designed and fabricated. Preliminary results exhibit the same of free spectral range of 100 GHz but different quality factors of 3700 and 3900 at 1550 nm for transverse electric (TE) and transverse magnetic (TM) mode, respectively. The extinction ratio is more than 18 dB over the entire C-band, and the insertion loss is lower than 9.5 dB for TE and TM mode