The Impact of Matching Vaccine Strains and Post-SARS Public Health Efforts on Reducing Influenza-Associated Mortality among the Elderly

Public health administrators do not have effective models to predict excess influenza-associated mortality and monitor viral changes associated with it. This study evaluated the effect of matching/mismatching vaccine strains, type/subtype pattern changes in Taiwan's influenza viruses, and the impact of post-SARS (severe acute respiratory syndrome) public health efforts on excess influenza-associated mortalities among the elderly. A negative binomial model was developed to estimate Taiwan's monthly influenza-associated mortality among the elderly. We calculated three winter and annual excess influenza-associated mortalities [pneumonia and influenza (P&I), respiratory and circulatory, and all-cause] from the 1999–2000 through the 2006–2007 influenza seasons. Obtaining influenza virus sequences from the months/years in which death from P&I was excessive, we investigated molecular variation in vaccine-mismatched influenza viruses by comparing hemagglutinin 1 (HA1) of the circulating and vaccine strains. We found that the higher the isolation rate of A (H3N2) and vaccine-mismatched influenza viruses, the greater the monthly P&I mortality. However, this significant positive association became negative for higher matching of A (H3N2) and public health efforts with post-SARS effect. Mean excess P&I mortality for winters was significantly higher before 2003 than after that year [mean ± S.D.: 1.44±1.35 vs. 0.35±1.13, p = 0.04]. Further analysis revealed that vaccine-matched circulating influenza A viruses were significantly associated with lower excess P&I mortality during post-SARS winters (i.e., 2005–2007) than during pre-SARS winters [0.03±0.06 vs. 1.57±1.27, p = 0.01]. Stratification of these vaccine-matching and post-SARS effect showed substantial trends toward lower elderly excess P&I mortalities in winters with either mismatching vaccines during the post-SARS period or matching vaccines during the pre-SARS period. Importantly, all three excess mortalities were at their highest in May, 2003, when inter-hospital nosocomial infections were peaking. Furthermore, vaccine-mismatched H3N2 viruses circulating in the years with high excess P&I mortality exhibited both a lower amino acid identity percentage of HA1 between vaccine and circulating strains and a higher numbers of variations at epitope B. Our model can help future decision makers to estimate excess P&I mortality effectively, select and test virus strains for antigenic variation, and evaluate public health strategy effectiveness

The Environmental Effects of Urban Development in Hanoi, Vietnam from Satellite and Meteorological Observations from 1999–2016

Since 1990 the Hanoi capital region (or Hanoi metropolitan area) in Vietnam has undergone rapid development, which has gone together with increasing socio-economic growth and prosperity. However, the environmental degradation that has accompanied urban development has raised considerable concern from the public in recent years. This research investigates the effects of urban development on urban sprawl, urban heat island (UHI), and metropolitan weather phenomena that are related to the quality of urban life in the period from 1999–2016. To achieve these objectives, remote sensing technologies were applied to satellite images at three time points (i.e., 1999, 2009, and 2016) that were associated with the meteorological dataset from ground-based stations. The spatial distribution evolution was examined for the land use/land cover changes while using the normalized difference vegetation index (NDVI) and normalized difference built-up index (NDBI). The increasing impact of urban sprawl on UHI intensity is determined based on the land surface temperature (LST) in multi-temporal forms. Increasing urbanization with the development of gradual outward and northward expansion from the city centre intensified the correlation analysis shows that the UHI. The potential formation of new UHI areas in the near future is also indicated. Furthermore, more than 30% of the metropolitan area is decaying in ecological quality according to an assessment of the urban thermal field variance index (UTFVI). With respect to metropolitan weather, the urbanization in Hanoi affected the observation of meteorological parameters revealed that the relative humidity, total rainfall, temperature, and wind speed over both urban and rural areas. The overall results imply that urban development and its environmental effects and impacts have imposed pressing issues and new challenges to sustainable development in the Hanoi metropolitan area

Landsat-MODIS image fusion and object-based image analysis for observing flood inundation in a heterogeneous vegetated scene

Typhoon flooding normally occurs suddenly with short duration, and the thick cloud cover limits the ability of one single satellite to timely capture the inundation extent. Landsat satellite data with a spatial resolution of 30 m is spatially applicable for flooding research; however, its 16-day observation frequency is typically insufficient to observe short-term typhoon inundation. Alternatively, despite the coarse spatial resolutions, the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor provide daily data, which is well suited for flood-related investigations. Accordingly, the idea of combining these two sources of data to generate a high spatial and temporal image would be useful. In this study, the Enhanced Spatial and Temporal Adaptive Reflectance Fusion Model (ESTARFM) was applied to generate cloud-free Landsat/MODIS synthesized data with a spatial resolution of 30 m for the delineation of the inundated areas during a flood event. This approach produces a Landsat-scale image for fine-scale flood mapping of areas where there are no observed cloud-free Landsat or similar resolution satellite images. The fusion model was implemented on atmospherically corrected surface reflectance, and the resultant reflectance values were validated by comparing with observed Landsat reflectance before further data interpretation. The blending results indicate that the synthetic Landsat-scaled image is highly correlated with Landsat surface reflectance, captured a day after the synthetic image acquisition date, over cloud-free areas. For image interpretation, an object-based image analysis (OBIA) approach with an optimal-scale segmentation and the support vector machine (SVM) classifier was applied for flood classification. The flood mapping result was validated by comparing with a reference flood map derived from an observed Landsat image. This study demonstrates that the techniques of image fusion and object-based image analysis are useful for observing flood inundation in the heterogeneous vegetated area

A Novel Approach to Relative Radiometric Calibration on Spatial and Temporal Variations for FORMOSAT-5 RSI Imagery

Radiometric calibration for imaging sensors is a crucial procedure to ensure imagery quality. One of the challenges in relative radiometric calibration is to correct detector-level artifacts due to the fluctuation in discrepant responses (spatial) and electronic instability (temporal). In this paper, the integration of the empirical mode decomposition (EMD) with Hilbert–Huang transform (HHT) in relative radiometric calibration was explored for a new sensor, FS-5 RSI (remote sensing instrument onboard the FORMOSAT-5 satellite). The key intrinsic mode functions (IMFs) analyzed by HHT were examined with the pre-flight datasets of the FS-5 RSI in temporal and spatial variations. The results show that the EMD–HHT method can stabilize and improve the radiometric quality of the FS-5 imagery as well as boost its application ability to a new level. It is noticed that the IMFs of the spatial variation would be disturbed by the instability of the temporal variation. The relative response discrepancies among detector chips can be well calibrated after considering the temporal effect. Taking a test imagery dataset of gain setting G2 as an example, the standard deviation (STD) of the discrepancy in the digital number after calibration was dramatically scaled down compared to the original ones (e.g., PAN: 66.31 to 1.85; B1: 54.19 to 1.90; B2: 36.50 to 1.49; B3: 32.43 to 1.56; B4: 37.67 to 1.20). The good performance of pre-flight imagery indicates that the EMD–HHT approach could be highly practical to the on-orbit relative radiometric calibration of the FS-5 RSI sensor and is applicable to other optical sensors. To our knowledge, the proposed EMD–HHT approach is used for the first time to explore relative radiometric calibration for optical sensors

Radiometric Variations of On-Orbit FORMOSAT-5 RSI from Vicarious and Cross-Calibration Measurements

A new Taiwanese satellite, FORMOSAT-5 (FS-5), with a payload remote sensing instrument (RSI) was launched in August 2017 to continue the mission of its predecessor FORMOSAT-2 (FS-2). Similar to FS-2, the RSI provides 2-m resolution panchromatic and 4-m resolution multi-spectral images as the primary payload on FS-5. However, the radiometric properties of the optical sensor may vary, based on the environment and time after being launched into the space. Thus, maintaining the radiometric quality of FS-5 RSI imagery is essential and significant to scientific research and further applications. Therefore, the objective of this study aimed at the on-orbit absolute radiometric assessment and calibration of on-orbit FS-5 RSI observations. Two renowned approaches, vicarious calibrations and cross-calibrations, were conducted at two calibration sites that employ a stable atmosphere and high surface reflectance, namely, Alkali Lake and Railroad Valley Playa in North America. For cross-calibrations, the Landsat-8 Operational Land Imager (LS-8 OLI) was selected as the reference. A second simulation of the satellite signal in the solar spectrum (6S) radiative transfer model was performed to compute the surface reflectance, atmospheric effects, and path radiance for the radiometric intensity at the top of the atmosphere. Results of vicarious calibrations from 11 field experiments demonstrated high consistency with those of seven case examinations of cross-calibration in terms of physical gain in spectra, implying that the practicality of the proposed approaches is high. Moreover, the multi-temporal results illustrated that RSI decay in optical sensitivity was evident after launch. The variation in the calibration coefficient of each band showed no obvious consistency (6%–24%) in 2017, but it tended to be stable at the order of 3%–5% of variation in most spectral bands during 2018. The results strongly suggest that periodical calibration is required and essential for further scientific applications