138 research outputs found
A proposed scoring system for assessing the severity of actinic keratosis on the head: actinic keratosis area and severity index
Background:
Actinic keratosis (AK) severity is currently evaluated by subjective assessment of patients.
Objectives:
To develop and perform an initial pilot validation of a new easy-to-use quantitative tool for assessing AK severity on the head.
Methods:
The actinic keratosis area and severity index (AKASI) for the head was developed based on a review of other severity scoring systems in dermatology, in particular the psoriasis area and severity index (PASI). Initial validation was performed by 13 physicians assessing AK severity in 18 AK patients and two controls using a physician global assessment (PGA) and AKASI. To determine an AKASI score, the head was divided into four regions (scalp, forehead, left/right cheek ear, chin and nose). In each region, the percentage of the area affected by AKs was estimated, and the severities of three clinical signs of AK were assessed: distribution, erythema and thickness.
Results:
There was a strong correlation between AKASI and PGA scores (Pearson correlation coefficient: 0.86). AKASI was able to discriminate between different PGA categories: mean (SD) AKASI increased from 2.88 (1.18) for ‘light’ to 5.33 (1.48) for ‘moderate’, 8.28 (1.89) for ‘severe’, and 8.73 (3.03) for ‘very severe’ PGA classification. The coefficient of variation for AKASI scores was low and relatively constant across all PGA categories.
Conclusions:
Actinic keratosis area and severity index is proposed as a new quantitative tool for assessing AK severity on the head. It may be useful in the future evaluation of new AK treatments in clinical studies and the management of AK in daily practice
Early invasive vulvar squamous cell carcinoma arising in a woman with vulvar pemphigus vulgaris and systemic lupus erythematosus
Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many parts of the body and the skin with occasional bullous lesions. Pemphigus vulgaris and SLE may be associated, albeit rarely. Here, we report the first case of a woman affected with SLE presenting with early invasive squamous cell carcinoma (SCC) arising from Pemphigus Vulgaris of the vulva
Evaluation of cases of pemphigus vulgaris and pemphigus foliaceus from a reference service in Pará state, Brazil
Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study
The influence of oral health and psycho-social well-being on clinical outcomes in Behcet's disease
Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan
Abortive aphthous-like oral lesions: an underreported initial presentation of pemphigus vulgaris
“Change over time in the treatment of pemphigus vulgaris between 2004 and 2016 in Iran”: A multiple cross‐sectional study
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