6 research outputs found
A theoretical treatment of energy transfer in a molecular motor based on Brownian motion on a multidimensional free-energy landscape: The derivation of formal analytic results in the Kramers regime of deep potential wells
A theoretical treatment of energy transfer in a molecular motor based on Brownian motion on a multidimensional free-energy landscape: The derivation of formal analytic results in the Kramers regime of deep potential wells
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. To identify common PrCa susceptibility alleles, we have previously conducted a genome-wide association study in which 541, 129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and 1,894 controls. We have now evaluated promising associations in a second stage, in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls, and a third stage, involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to previously identified loci, we identified a further seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11, and 22 (P=1.6×10−8 to P=2.7×10−33)