Développement d'une technique de PCR en temps réel pour le diagnostic de l'aspergillose invasive à "Aspergillus fumigatus" (évaluation chez 47 patients)

PARIS-BIUP (751062107) / SudocSudocFranceF

Airway Colonization by Acrophialophora fusispora in Patients with Cystic Fibrosis

Acrophialophora fusispora is a thermotolerant soil fungus which is very unusual in clinical samples. Here we report four cases of transient or chronic airway colonization by A. fusispora in patients with cystic fibrosis (CF). However, the prevalence of this fungus in CF patients may be underestimated due to the currently poor knowledge of this fungus in most of the medical mycology laboratories. In addition, its clinical importance regarding CF remains to be evaluated

Evaluation of a new mobile system for protecting immune-suppressed patients against airborne contamination.

International audienceBACKGROUND: Invasive aspergillosis is one of the most lethal airborne dangers for immune-suppressed subjects. Providing patient protection from such airborne threats requires costly and high-maintenance facilities. We herein evaluate a new self-contained mobile unit as an alternative for creating a patient protective environment. METHODS: Airborne contamination levels were monitored for different simulated scenarios and under actual clinical conditions. Functional tests were used to challenge the unit under adverse conditions, and a preliminary clinical study with patients and staff present was performed at 2 different French hospitals. RESULTS: Functional tests demonstrated that the unit can rapidly decontaminate air in the protected zone created by the unit and in the surrounding room. In addition, the protected zone is not sensitive to large disturbances that occur in the room. The clinical study included 4 patients with 150 accumulated days of testing. The protected zone created by the unit systematically provided an environment with undetectable airborne fungal levels (ie, <1 CFU/m(3)) regardless of the levels in the room or corridor (P < .01). CONCLUSIONS: These tests show that the unit can be used to create a mobile protective environment for immune-suppressed patients in a standard hospital setting