Synthesis and characterization of some chromium(III) complexes with N ,S, O-donor thiohydrazones

1140-1144The preparation and characterization of some new chromium(III) complexes synthesized by the reactions of salicylaldehyde morpholine N-thiohydrazone (H2smth) and 2 hydroxyacetophenone morpholine N-thiohydrazone (H2apmth) with different chromium(III) salts, under varied reaction conditions are reported. The isolated solid chromium(III) complexes have been characterised by elemental analyses, molar conductance, magnetic susceptibilities, molecular weights and spectroscopic (UV-Vis and IR) data. It has been observed that the ligands H2smth and H2apmth can function either as a monobasic tridentate or dibasic tridentate (N,S,O-donor) fashion depending on the reaction conditions

Synthesis and characterization of chromium(III) complexes of diacetyl bis (4-methoxybenzoyl hydrazone)

679-682A few chromium(III) complexes have been synthesized from reactions of diacetyl bis(4-methoxybenzoyl hydrazone) (H2 dambhon) with CrCI3. 6H2O, NH4 [Cr(SCN)4(NH3)2H2O and K3[Cr(SCN)6]. 4H2O. The complex [Cr(dambhon)(Py)CI.H2O (2), reacts with acetylacetone, salicylaldehyde, glycine and N-phenylsalicylaldimine to yield chromium(III) heterochelates of the type [Cr(dambhon)(L-L)J.nH2O [where L-L = anion of acetylacetone, n = 1 (5); anion of salicylaldehyde, n = 1, (6); anion of glycine, n = 2, (7) and anion of N-phenylsalicylaldimine, n = 1, (8)]. The complexes have been characterised by elemental analysis, molar conductance values, magnetic susceptibilities, molecular weights and spectroscopic (UV-vis and IR) data. It has been concluded that the formation of the complexes (1) to (8) involves quadridentate N2O2 donor ligand (H2 dambhon) in the dibasic form (dambhon2-)

Synthesis and characterization of dioxomolybdenum(VI) and oxomolybdenum(V) complexes of salicylaldehyde morpholine Nthiohydrazone (H₂smth) and 2-hydroxyacetophenone morpholine <span style="font-size:14.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:EN-US; mso-bidi-language:AR-SA">N-thiohydrazone <span style="font-size:14.0pt; font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">(H_{<span style="font-size:14.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:EN-US; mso-bidi-language:AR-SA">2</span>}<span style="font-size:14.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">apmth)</span></span></span>

381-384A few dioxomolybdenum(VI) and oxomolybdenum(V) complexes have been synthesised with tridentate NSO donor hydrazone ligands derived by the condensation of morpholine Nthiohydrazide with salicylaldehyde and 2-hydroxyacetophenone. The complexes have been characterized by  elemental analyses, molecular weights, magnetic moments, molar conductances, <span style="font-size: 14.0pt;font-family:Arial;mso-fareast-font-family:" times="" new="" roman";mso-ansi-language:="" en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">infrared and electronic spectral data The ligands are found to act in dibasic tridentate <span style="font-size:14.0pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">fashion.</span

Synthesis and characterization of iron(III) complexes of salicylaldehyde 4-methoxybenzoyl hydrazone

107-111lron(lll) complexes of salicylaldehyde 4-methoxybenzoyl hydrazone, (H2smbhon), have been isolated and the reactions of [Fe(smbhon) (Cl) (H2O)]2 with SnCl2 and CH3CN are discussed. These complexes have been characterised by elemental analyses, molar conductance values, magnetic susceptibilities, molecular weights and spectroscopic (electronic,infrared and Mössbauer) data. Depending on the reaction conditions, the ligand may function as a dibasic tridentate, monobasic or neutral bidentate ligand

Protective role of fish oil (Maxepa) on early events of rat mammary carcinogenesis by modulation of DNA-protein crosslinks, cell proliferation and p53 expression

BACKGROUND: Fish oil is known to protect from many types of cancers of the colon, liver, breast, prostate and lung [1-3]. The objective of the present study was to evaluate the role of fish oil [Maxepa, supplemented at a dose of 0.5 ml is equivalent to 90 mg eicosapentaenoic acid (EPA) and 60 mg docosahexaenoic acid (DHA)] on cell proliferation, expression of p53 tumor suppressor protein and DNA protein crosslinks (DPCs) in a defined model of chemical rat mammary carcinogenesis. Mammary carcinogenesis was initiated by a single, intravenous (i.v.) tail vein injection of 7,12 dimethylbenz(α)anthracene (DMBA) at a dose of 5 mg DMBA/2 ml corn oil/kg body weight in female Sprague-Dawley rats at 7 weeks of age. Fish oil supplementation was started daily, 2 weeks prior to DMBA injection and continued for 24 (31 weeks of animal age) weeks and 35 (42 weeks of animal age) weeks of post DMBA injection, for histopathological and immunohistochemical and for morphological studies, respectively. RESULTS: Our results indicate the chemopreventive effect of fish oil (Maxepa) on DMBA-induced rat mammary carcinogenesis. Administration of fish oil further showed a prominent reduction of cell proliferation (24.34%, P = 0.001); DPCs (25%, P < 0.001) and an increased expression of p53 protein (4.636 ± 0.19, P < 0.001) in preneoplastic mammary tissue when compared to carcinogen control counterpart. Histopathological and morphological analyses were carried out as end-point biomarkers. CONCLUSION: Our study thus provides evidence for the anticarcinogenic effect of fish oil (Maxepa) in limiting mammary preneoplasia in Sprague-Dawley rats

Synthesis and characterization of iron(III) complexes of diacetylbis- (4-methoxybenzoyl hydrazone)

529-534A few mono- and binuclear iron(III) complexes have been isolated by the reaction of diacetylbis( 4-methoxybenzoyl hydrazone), H2dambhon with iron salts under varied reaction conditions. Some reactions of [(dambhon)Fe(Cl)(H2O)].4H2O, isolated in this study, with acetylacetone, pyridine, SnCl2 and PPh3 have been carried out which afforded new iron(III) complexes. The new complex [(dambhon)Fe(PPh3)Cl], thus prepared, smoothly reacts with thiomethanol, N-trimethylsilyldimethylamine, benzyltrimethylsilane, and p-bis(trimethylsilylmethyl)benzene leading to the isolation of several new iron(III) and organoiron(III) compounds.. The complexes are characterized on the basis of elemental analyses, molar conductance, molecular weight, magnetic susceptibilities and spectroscopic (electronic, IR and Mössbauer) data. The ligand H2 dambhon in these complexes functions as a NNOO donor either as a mono- or dianion or neutral ligand

<span style="font-size:12.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-ansi-language: EN-IN;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">Synthesis and charaterisation of cobalt complexes of salicylaldehyde 4-methoxybenzoyl hydrazone (H₂ smbhon)</span>

1139-1144A number of mononuclear and dinuclear cobalt(II) and cobalt(III) complexes have been isolated by reacting salicylaldehyde 4- methoxybenzoyl hydrazone (H2smbhon) with CoCI2.6H2O, CO(NO3)26H2O, Co(CH3COO)2.4H2O and Co(acac)3 under varied reaction conditions. [CoII(smbhon)(H2O)3], isolated in this study, further reacts with pyridine (Py) dipyridine (dip) and triphenylphosphine (Ph3P) in presence of NaCIO4 to form new cobalt(III) complexes. Equimolar mixtures of [CoII(smbhon)(H2O)3] and the ligands like acetylacetone (Hacac), glycine (Hgly), N,N-bisethyleneacteophenoneimine (bape),N-phenylsalicylaldimine (Haslan), N-phenylorthohydroxyacetophenoneimine (Hohapan), N-hydroxymethylsalicylaldimine (H2salgly), N-2-hydroxyphenylsalicylaldimine (H2saloap) or N-2-carboxyphenylsalicylaldimine (H2salana) on refluxing in methanol-acetonitrile in the presence of oxygen at pH ~ 9 afford coloured heterochelates of cobalt (III) in high yields. Structures of the complexes have been assigned on the basis of elemental analyses, molecular weights, molar conductances, magnetic moments and spectral (UV -vis and IR) studies. The physico-chemical data suggest that H2smbhon can behave as a dibasic tridentate (ONO) donor, monobasic tridentate (ONO) (keto form) donor and monobasic bidentate (NO) donor depending on the reaction conditions

Metal-Catalyzed Domino Synthesis of Benzophenanthridines and 6<i>H</i>‑Naphtho[2,3‑<i>c</i>]‑chromenes

A new and efficient synthesis of tetracyclic phenanthridines and benzo­[<i>c</i>]­chromenes has been described involving a metal-mediated two-step domino strategy. The first step involved efficient palladium-catalyzed domino carbopalladation/cross coupling, and the second step involved iron-catalyzed domino isomerization/cyclodehydration. The important features of this strategy include high yields, generality, wide substrate scope, and broad functional group tolerance. A plausible mechanism has been proposed to explain the formation of the product

Metal-Catalyzed Domino Synthesis of Benzophenanthridines and 6<i>H</i>‑Naphtho[2,3‑<i>c</i>]‑chromenes

A new and efficient synthesis of tetracyclic phenanthridines and benzo­[<i>c</i>]­chromenes has been described involving a metal-mediated two-step domino strategy. The first step involved efficient palladium-catalyzed domino carbopalladation/cross coupling, and the second step involved iron-catalyzed domino isomerization/cyclodehydration. The important features of this strategy include high yields, generality, wide substrate scope, and broad functional group tolerance. A plausible mechanism has been proposed to explain the formation of the product