Risk Factors for Development of Rhegmatogenous Retinal Detachment in Patients with Uveitis

Purpose: To describe risk factors for development of rhegmatogenous retinal detachment (RRD) in patients with uveitis. Methods: We performed a retrospective review of 411 consecutive human immunodeficiency virus-negative patients with uveitis (571 affected eyes) and report on prevalence, risk factors and visual outcomes of patients with RRD. Results: Prevalence of RRD was 7% of all patients with uveitis. Multivariate analysis revealed that posterior uveitis and panuveitis were associated with RRD (P = 0.001). Strong association between RRD development and infectious uveitis was also observed (P = 0.009). Acute retinal necrosis (ARN) was firmly associated with RRD development (P = 0.016). Although anatomical success was obtained, functional outcome was poor. Poor visual outcomes at 6-month and 1-year follow-up were associated with initial VA < counting fingers (P = 0.05, P = 0.044). Conclusions: Prevalence of RRD in uveitis was 7% and development of RRD was encountered in posterior and panuveitis. Infectious uveitis (specifically ARN) formed a high risk for RRD

Primary Rhegmatogenous Retinal Detachment Repair by Pars Plana Vitrectomy With and Without Scleral Buckling: A Propensity Score Analysis [Response to Letter]

Pongthep Rajsirisongsri,1 Direk Patikulsila,1 Phichayut Phinyo,2&ndash;4 Paradee Kunavisarut,1 Voraporn Chaikitmongkol,1 Onnisa Nanegrungsunk,1 Atitaya Apivatthakakul,1 Sutheerada Seetasut,1 Yaowaret Tantivit,1 Napatsorn Krisanuruks,1 Apisara Sangkaew,1 Nawat Watanachai,5 Janejit Choovuthayakorn1 1Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; 2Clinical Epidemiology and Clinical Statistics Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; 3Department of Biomedical Informatics and Clinical Epidemiology (Bioce), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; 4Musculoskeletal Science and Translational Research (MSTR), Chiang Mai University, Chiang Mai, Thailand; 5Department of Ophthalmology, Faculty of Medicine, Mahidol University, Bangkok, ThailandCorrespondence: Janejit Choovuthayakorn, Email [email protected]

Supplementary Material for: Reference Database of Inner Retinal Layer Thickness and Thickness Asymmetry In Healthy Thai Adults as Measured by The Spectralis Spectral-Domain Optical Coherence Tomography

Purpose: To determine a reference database of the thickness and intraocular thickness asymmetry of total retina, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) in healthy Thai subjects measured by the Spectralis spectral-domain optical coherence tomography Methods: This cross-sectional study recruited the healthy subjects age ≥18 years, having spherical refraction within ±6 diopters and cylindrical refraction ±3 diopters, from a hospital’s personnel and the people accompanying patients visiting the ophthalmology department. If the eligibility criteria were met for both eyes, only 1 eye of each subject was randomly selected for an analysis. Macular images were obtained using posterior pole thickness scan protocol over a 24x24 degree area at the center of the fovea. The automated retinal thickness segmentation values of total retina and three inner retinal layers were calculated for the mean and the mean intraocular thickness difference between superior and inferior retinal hemispheres. The influence of age, gender, and axial length on thickness and thickness asymmetry of individualized retinal layer were evaluated. Results: Two hundred and fifty-two subjects were included in study with a mean (SD) age of 46.7 (15.8) years and 120 (47.6%) were males. According to the Early Treatment Diabetic Retinopathy Study map, the inner ring area was the thickest location of the total retina (range; 326.0 to 341.5 µm), ganglion cell layer (range; 47.7 to 52.7 µm), and inner plexiform layer (range; 39.9 to 42.1 µm); whereas the thickest location of RNFL was at the outer ring area (range; 18.8 to 47.5 µm). For posterior pole intraocular thickness asymmetry, the greatest mean ± SD difference was observed for total retina (9.0 ± 2.2 µm), followed by RNFL (9.9 ± 3.2 µm), and GCL (2.7 ± 0.6 µm) and the lowest mean difference was noted for IPL (2.4 ± 0.5 µm). The thickness and thickness asymmetry of each retinal layer were variably influenced by age, gender, and axial length; however, these factors had a minimal influence on the thickness asymmetry maps of GCL and RNFL. Conclusion: The reference database of the macular thickness and thickness asymmetry from this study would be beneficial in determining physiologic variations of the OCT parameters in the healthy Thai population

Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant

none14mixedZur D; Iglicki M; Sala-Puigdollers A; Chhablani J; Lupidi M; Fraser-Bell S; Mendes TS; Chaikitmongkol V; Cebeci Z; Dollberg D; Busch C; Invernizzi A; Habot-Wilner Z; Loewenstein AZur, D; Iglicki, M; Sala-Puigdollers, A; Chhablani, J; Lupidi, M; Fraser-Bell, S; Mendes, Ts; Chaikitmongkol, V; Cebeci, Z; Dollberg, D; Busch, C; Invernizzi, A; Habot-Wilner, Z; Loewenstein,