21 research outputs found
Global regularity criterion for the 3D Navier-Stokes equations involving one entry of the velocity gradient tensor
In this paper we provide a sufficient condition, in terms of only one of the
nine entries of the gradient tensor, i.e., the Jacobian matrix of the velocity
vector field, for the global regularity of strong solutions to the
three-dimensional Navier-Stokes equations in the whole space, as well as for
the case of periodic boundary conditions
An immunohistochemical study of the expression of cell-cycle-regulated proteins p53, cyclin D1, RB, p27, Ki67 and MSH2 in gallbladder carcinoma and its precursor lesions
Gallbladder carcinomas are rare but highly
lethal neoplasms. We examined the expression of five
cell-cycle-related molecules (p53, RB, cyclin D1, p27,
Ki-67), and MSH2, in 46 carcinomas, 14 adenomas, 15
low-grade dysplasias, 9 intestinal metaplasias and 20
normal gallbladder epithelia. The expression of these
molecules was altered in gallbladder carcinomas and
adenomas. In gallbladder carcinomas we observed
increased expression of p53, cyclin D1, Ki-67, and
MSH2 together with decreased expression of RB and
p27 protein. Aberrant expression of cyclin D1 and
reduced expression of RB were noted in adenomas, and
expression of cyclin D1 was elevated in low-grade
dysplasias. However, there was no change in the levels
of these cell-cycle molecules in metaplasia. Expression
of p53, p27, Ki-67, and MSH2 was correlated with
clinical stage (P<0.05) and there was also a correlation
between the expression of Ki-67 and MSH-2 and patient
age (P<0.05). These results suggest that altered
expression of cell-cycle molecules p53, cyclin D1, RB,
p27, and of MSH-2 is involved in the progression of
gallbladder carcinomas
344 A STUDY OF OPTIMAL TROCAR SITE FOR EXTRA-PERITONEAL APPROACH TO ROBOT ASSISTED LAPAROSCOPIC RADICAL PROSTATECTOMY IN KOREANS
Mapping expressive differences around the world:The relationship between emotional display rules and individualism versus collectivism
Measurement of the Interleukin Family Member ST2 in Patients With Acute Dyspnea Results From the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) Study
ObjectivesThe aim of this study was to examine the value of measurement of the interleukin-1 receptor family member ST2 in patients with dyspnea.BackgroundConcentrations of ST2 have been reported to be elevated in patients with heart failure (HF).MethodsFive hundred ninety-three dyspneic patients with and without acute destabilized HF presenting to an urban emergency department were evaluated with measurements of ST2 concentrations. Independent predictors of death at 1 year were identified.ResultsConcentrations of ST2 were higher among those with acute HF compared with those without (0.50 vs. 0.15 ng/ml; p < 0.001), although amino-terminal pro-brain natriuretic peptide (NT-proBNP) was superior to ST2 for diagnosis of acute HF. Median concentrations of ST2 at presentation to the emergency department were higher among decedents than survivors at 1 year (1.08 vs. 0.18 ng/ml; p < 0.001), and in multivariable analyses, an ST2 concentration ≥0.20 ng/ml strongly predicted death at 1 year in dyspneic patients as a whole (HR = 5.6, 95% confidence interval [CI] 2.2 to 14.2; p < 0.001) as well as those with acute HF (hazard ratio [HR] = 9.3, 95% CI 1.3 to 17.8; p = 0.03). This risk associated with an elevated ST2 in dyspneic patients with and without HF appeared early and was sustained at 1 year after presentation (log-rank p value <0.001). A multi-marker approach with both ST2 and NT-proBNP levels identified subjects with the highest risk for death.ConclusionsAmong dyspneic patients with and without acute HF, ST2 concentrations are strongly predictive of mortality at 1 year and might be useful for prognostication when used alone or together with NT-proBNP