38 research outputs found

    Chimioprophylaxie primaire de l'aspergillose invasive par voriconazole au cours du traitement d'induction de leucémie aiguë en période de travaux

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    Invasive aspergillosis (IA) remains a major cause of morbidity and mortality in acute leukemia patients, despite recent advances in diagnosis and treatment. We performed a retrospective observational cohort study to show the impact of a primary prophylaxis with voriconazole during induction-remission chemotherapy, in an outbreak situation due to construction work. We included 257 patients between 2003 and 2005 in the hematological ward of Purpan Hospital (Toulouse, France), 88 of them received a primary prophylaxis. The incidence of IA was 4.5% in the prophylaxis group and 12.4% in the control group (p=0.04). Survival and side-effects were similar in each group. Our study confirms the potential benefit of azole antifungals for primary prophylaxis during induction-remission chemoprophylaxis, that has already been shown in a randomized multicenter study with posaconazole.TOULOUSE3-BU Santé-Centrale (315552105) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

    Recherches historiques et gĂ©omorphologiques sur la localisation de l’hippodrome de Delphes

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    L’emplacement exact de l’hippodrome de Delphes est depuis peu fortement dĂ©battu. Il est vrai que l’imprĂ©cision des sources littĂ©raires, associĂ©e Ă  des paysages qui ont fortement changĂ© depuis plus de 2000 ans n’ont toujours pas permis sa localisation. Dans cet article, une double approche originale fondĂ©e sur l’étude approfondie de ces fragments littĂ©raires et Ă©pigraphiques ainsi que sur une Ă©tude gĂ©omorphologique de terrain nous a permis de mettre en Ă©vidence une zone susceptible d’avoir accueilli les courses hippiques dans l’AntiquitĂ©. SituĂ©e au bas du versant sud du sanctuaire et lĂ©gĂšrement au-dessus de la plaine, sa surface plane au sol est d’environ 11 hectares. L’argument topographique ne suffisant pas pour proposer une hypothĂšse sĂ©rieuse, diffĂ©rents critĂšres indispensables Ă  l’établissement d’un hippodrome ont Ă©tĂ© ici discutĂ©s et confrontĂ©s aux dynamiques environnementales locales : dimensions de la piste, prĂ©sence ou non d’eau Ă  proximitĂ©, accessibilitĂ© et distance au sanctuaire et enfin possibilitĂ© d’amĂ©nager cet espace pour les spectateurs

    Stigmatisation et coping chez les femmes obĂšses

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    TOULOUSE2-BUC Mirail (315552102) / SudocSudocFranceF

    Relations between suicidal ideation and dimensions of depressive symptoms in high‐school students

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    Abstract The aim of the study was to evaluate the link between the different dimensions of depressive symptoms and suicidal ideation in adolescents. A sample of 1057 adolescents completed the CES‐D (Center for Epidemiological Studies Depression Scale) and three additional items measuring suicidal ideation. The four dimensions of depressive symptoms on the CES‐D (Depressed Affect, Loss of Positive Affect, Somatic and Retarded Activity, Interpersonal) were entered into regression analyses predicting the presence of any suicidal ideation and of the wish to kill oneself among participants with moderate/severe depressive symptoms ( ). For both boys and girls Depressed Affect was the main significant predictor of the presence of any suicidal ideation and of the wish to kill oneself. There were two additional significant predictors for boys: Loss of Positive Affect positively predicted the presence of any suicidal ideation; Somatic and Retarded Activity negatively predicted the presence of the wish to kill oneself
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