Spin and Gauge Systems on Spherical Lattices

We present results for 2D and 4D systems on lattices with topology homotopic to the surface of a (hyper) sphere $S^2$ or $S^4$. Finite size scaling is studied in situations with phase transitions of first and second order type. The Ising and Potts models exhibit the expected behaviour; for the 4D pure gauge $U(1)$ theory we find consistent scaling indicative of a second order phase transition with critical exponent $\nu\simeq 0.36(1)$.Comment: 4 pages, LaTeX, 3 POSTSCRIPT figures (uuencoded

A compact dual atom interferometer gyroscope based on laser-cooled rubidium

We present a compact and transportable inertial sensor for precision sensing of rotations and accelerations. The sensor consists of a dual Mach-Zehnder-type atom interferometer operated with laser-cooled $^{87}$Rb. Raman processes are employed to coherently manipulate the matter waves. We describe and characterize the experimental apparatus. A method for passing from a compact geometry to an extended interferometer with three independent atom-light interaction zones is proposed and investigated. The extended geometry will enhance the sensitivity by more than two orders of magnitude which is necessary to achieve sensitivities better than $10^{-8}$rad/s/$\sqrt{\rm Hz}$.Comment: 9 pages, 8 figure

The genetics of the Lp Antigen

Several genetic models were considered to explain the distribution of qualitatively positive and negative children in 204 Caucasian families. A model which best describes the inheritance of the Lp antigenic expression involves a major genetic locus which distinguishes two overlapping continuously distributed modes of quantitative activity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66139/1/j.1469-1809.1974.tb01992.x.pd

Phase-locking of two self-seeded tapered amplifier lasers

We report on the phase-locking of two diode lasers based on self-seeded tapered amplifiers. In these lasers, a reduction of linewidth is achieved using narrow-band high-transmission interference filters for frequency selection. The lasers combine a compact design with a Lorentzian linewidth below 200 kHz at an output power of 300 mW. We characterize the phase noise of the phase-locked laser system and study its potential for coherent beam-splitting in atom interferometers.Comment: 7 pages, 4 figure

High prevalence of mixed infections by Helicobacter pylori in Hong Kong: Metronidazole sensitivity and overall genotype

Background: Diversity in metronidazole susceptibility and genotypes of Helicobacter pylori have been reported with varying results in different areas. Aims: To investigate the prevalence of multiple strain infection in a symptomatic Chinese population and to determine the metronidazole susceptibility pattern and genotypic characteristics of these infecting strains. Methods: Gastric biopsies from antrum, body and cardia were taken during upper endoscopy in symptomatic patients referred to our department. Pooled cultures and single colony isolates were obtained and tested for metronidazole susceptibility and random amplified polymorphic DNA (RAPD) fingerprint patterns. Results: A total of 461 isolates were successfully cultured from 46 patients. Fifty-seven per cent of subjects had metronidazole-resistant strains. Among them, 77% carried a mixture of sensitive and resistant strains, non-uniformly distributed in the gastric mucosa. Mixed genotypes were found by RAPD typing in 24% of subjects. These did not correlate with the metronidazole susceptibility/resistance pattern. Conclusion: H. pylori infections with mixed metronidazole sensitive/resistant strains and mixed genotypes are common in Hong Kong. This makes it prudent to use bacterial strains from several biopsy sites when testing for traits such as drug resistance or virulence in relation to disease.postprin

High prevalence of Helicobacter pylori infection with dual resistance to metronidazole and clarithromycin in Hong Kong

Background: Metronidazole resistance is a common problem in most Asian countries, and clarithromycin has been widely used in Hong Kong. Aim: To determine the prevalence of Helicobacter pylori strains resistant to metronidazole and clarithromycin in Hong Kong and to assess the effect on eradication rates. Also to determine the genetic mutation in relation to phenotypic divergence in clarithromycin-resistant strains. Methods: H. pylori were cultured from gastric biopsies obtained from 87 patients during upper endoscopy. Minimal inhibitory concentrations of metronidazole and clarithromycin were determined by Etest and agar dilution methods. Mutations in clarithromycin-resistant strains were identified by polymerase chain reaction and restriction analysis. Random amplified polymorphic DNA fingerprinting was performed on clarithromycin-resistant and susceptible isolates. Results: The prevalences of H. pylori strains resistant to metronidazole and clarithromycin were 49.4% and 10.8%, respectively, in Hong Kong. Dual resistance to metronidazole and clarithromycin were found in 7.2% of patients. The agreement between E-test and agar dilution methods was determined by error-rate bound analysis as 95.4% for metronidazole and 100% for clarithromycin. Dual resistant strains reduced the eradication rate to 66.7%. Among clarithromycin-resistant strains tested, all were due to A2144G point mutation in 23S rRNA gene. Random amplified polymorphic DNA fingerprinting suggested various phenotypically mixed populations. Conclusions: The prevalence of metronidazole-resistant H. pylori strains remained static whilst the prevalence of clarithromycin-resistant strains was not rare in Hong Kong. An alarming 7.2% of patients were resistant to both the antimicrobials, which had a definite impact on treatment success. All cases of resistance to clarithromycin were due to A2144G mutation in 23S rRNA of H. pylori.postprin

Dynamics of Phase Transitions by Hysteresis Methods I

In studies of the QCD deconfining phase transition or crossover by means of heavy ion experiments, one ought to be concerned about non-equilibrium effects due to heating and cooling of the system. Motivated by this, we look at hysteresis methods to study the dynamics of phase transitions. Our systems are temperature driven through the phase transition using updating procedures in the Glauber universality class. Hysteresis calculations are presented for a number of observables, including the (internal) energy, properties of Fortuin-Kasteleyn clusters and structure functions. We test the methods for 2d Potts models, which provide a rich collection of phase transitions with a number of rigorously known properties. Comparing with equilibrium configurations we find a scenario where the dynamics of the transition leads to a spinodal decomposition which dominates the statistical properties of the configurations. One may expect an enhancement of low energy gluon production due to spinodal decomposition of the Polyakov loops, if such a scenario is realized by nature.Comment: 12 pages, revised after referee report, to appear in Phys. Rev.

Recommendations for a core outcome set for measuring standing balance in adult populations: a consensus-based approach

Standing balance is imperative for mobility and avoiding falls. Use of an excessive number of standing balance measures has limited the synthesis of balance intervention data and hampered consistent clinical practice.To develop recommendations for a core outcome set (COS) of standing balance measures for research and practice among adults.A combination of scoping reviews, literature appraisal, anonymous voting and face-to-face meetings with fourteen invited experts from a range of disciplines with international recognition in balance measurement and falls prevention. Consensus was sought over three rounds using pre-established criteria.The scoping review identified 56 existing standing balance measures validated in adult populations with evidence of use in the past five years, and these were considered for inclusion in the COS.Fifteen measures were excluded after the first round of scoring and a further 36 after round two. Five measures were considered in round three. Two measures reached consensus for recommendation, and the expert panel recommended that at a minimum, either the Berg Balance Scale or Mini Balance Evaluation Systems Test be used when measuring standing balance in adult populations.Inclusion of two measures in the COS may increase the feasibility of potential uptake, but poses challenges for data synthesis. Adoption of the standing balance COS does not constitute a comprehensive balance assessment for any population, and users should include additional validated measures as appropriate.The absence of a gold standard for measuring standing balance has contributed to the proliferation of outcome measures. These recommendations represent an important first step towards greater standardization in the assessment and measurement of this critical skill and will inform clinical research and practice internationally