Synthesis and antimicrobial activity of 2-((4-(1H-benzo[d]imidazol-2-yl)-6-(2-ethylcyclopentyl) pyrimidin-2-yl)thio)-N-methylacetamide

It was possible to synthesise a brand new series of 2-((4-(1H-benzo[d]imidazol-2-yl)-6-(2-ethylcyclopentyl)pyrimidin-2-yl)thio)-N-methyl acetamide (4a-h). The reaction of 1-(1H-benzimidazol-2-yl)ethanone with 2-ethylcyclopentane carbaldehyde with ethanol and KOH yielded (E)-1-(1H-benzo[d]imidazol-2-yl)-3-(2-ethylcyclopentyl)prop-2-en-1-one (1a-c). All compounds shown to have antimicrobial action via pharmacological study are listed here. . Chloramphenicol and Amphotericin B, two conventional antibiotics, were compared to the antibacterial and antifungal properties of synthetic compounds. It was discovered that Schlenter products had spectroscopic properties worth investigating

Greener One-pot Synthesis of Chromeno Oxazin and Oxazin Quinoline Derivatives and their Antibacterial Activity

An efficient green method for the synthesis of oxazino quinoline-2-amine derivatives, oxazino quinoline derivatives and chromeno oxazin-5-one derivatives have been synthesized through cyclization of aromatic aldehyde, ammonium acetate, substituted amides and 8-hydroxy-quinoline or 4-hydroxy coumarin by one-pot condensation method is described. The synthesized compounds are characterized by FT-IR, 1H NMR and MASS spectral techniques and are screened further for biological activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis using cup plate method and disc diffusion method

Synthesis and antimicrobial activity of 2-((4-(1H-benzo[d]imidazol-2-yl)-6- (2-ethylcyclopentyl) pyrimidin-2-yl)thio)-N-methylacetamide

816-822It has been possible to synthesise a brand new series of 2-((4-(1H-benzo[d]imidazol-2-yl)-6- (2-ethylcyclopentyl)pyrimidin-2-yl)thio)-N-methyl acetamide 4a-h. The reaction of 1-(1H-benzimidazol-2-yl)ethanone with 2-ethylcyclopentane carbaldehyde with ethanol and KOH yields (E)-1-(1H-benzo[d]imidazol-2-yl)-3- (2-ethylcyclopentyl)prop-2-en-1-one 1a-c. All compounds have been shown to have antimicrobial action via pharmacological study and are listed here. Chloramphenicol and Amphotericin B, two conventional antibiotics, have been compared to the antibacterial and antifungal properties of the synthetic compounds. It has been discovered that Schlenter products had spectroscopic properties worth investigating

Synthesis and antibacterial activity of <i style="mso-bidi-font-style:normal">N</i>-substituted-[1,2,4]triazoles and 1,2,4-triazole[3,4-b][1,3,4]thiadiazines

1283-1289New series of N-[3-(5-methyl-1-phenyl-1H-4-pyrazolyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]-N'-arylthiourea derivatives 8a-e and 3-(5-methyl-1-phenyl-1H-4-pyrazolyl)-6-aryl-7H-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazines 9a-e have been prepared and screened for their antibacterial activity against four human pathogenic bacteria, Escherichia coli, Klebseilla pneumoniae, Shigella dysentriae and Shigella flexnei. Among the screened, compounds 8b, <b style="mso-bidi-font-weight: normal">8c and 8e, in which phenyl ring of isothiocyanate moiety bear 3-fluoro, 4-fluoro and 4-bromo substituents respectively, show high activity against all the micro-organisms employed. The compound 9c is highly active against all the test organisms employed. The zone of inhibition is more than what is found for the standard drug neomycin, and almost equal to the standard drug streptomycin

<span style="font-size:11.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-GB">Synthesis and antibacterial activity of di-heteryl substitued [1,2,4]triazolo [3,4-<i>b</i>][1,3,4]thiadiazoles</span>

590-597A new series of 3-(5-methyl-1-phenyl-1H-4-pyrazolyl)-6-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)[1,2,4]triazolo [3,4-b][1,3,4]thiadiazoles 12a-j have been prepared and assayed for their antibacterial activity against human pathogenic Gram-positive bacteria viz., Staphylococcus aureus, Bacillus subtilis and Gram-negative Escherichia coli. Among the screened compounds 12b, 12c and 12f, in which phenyl ring of triazole moiety bear 4-chloro, 4-nitro and 4-fluoro substituents respectively, showed high activity against all the micro-organisms employed. The activities of these compounds are almost equal to the standards.</span