Early postburn fatty acid profile in burn patients

To understand the alterations in lipid metabolism following burn injury, 29 patients with burns, 18 survivors for the first 15 days and 11 non-survivors until death, were studied for total fatty acid (FA) profiles. No specific dietary fat was given. The plasma total FA profile was determined by capillary gas chromatography

PROLONGED ALLOGRAFT SURVIVAL IN A PATIENT WITH EXTENSIVE BURNS USING CYCLOSPORINE

A woman with very extensive bums (of over 75 per cent TBSA and 45 per cent full skin thickness) received cyclosporin to extend the survival of skin allografts obtained from several unmatched donors. The patients' wounds appeared completely healed after 3 months when the cyclosporin was discontinued. During the immunosuppressive treatment with cyclosporin there was no evidence of graft rejection or any side effects related to cyclosporin, Twelve days after discontinuing the drug rejection started. The bums were then successfully covered with autografts during two operations. The late functional results were excellent

AN EASY METHOD OF HARVESTING EPIDERMAL AND DERMAL SKIN ALLOGRAFTS FOR RATS

A method for obtaining large amounts of epidermal (split thickness) and dermal skin allografts is described. Animals are inflated with air subcutaneously after killing, and both grafts are taken by Watson knife consecutively

Effects of Sewage Sludge Applications on Plant Growth of Liquidambar orientalis Species

WOS: 000450763800007In this research, it was aimed to determine the effects of usage taken sewage sludge from Gokova-Akyaka Wastewater Treatment Plant on plant growth of Liquidambar orientalis species. In the experiment, sewage sludge was applied as 20 kg m(2) year(-1) dose and totally 12 times once in four months during two years (0 kg m(2) year(-1), 20 kg m(2) year(-1), 40 kg m(2) year(-1), 60 kg m(2) year(-1)). For this reason plant height, body diameter, leaf color, some plant nutrients and heavy metals analyses were done. As a result of two year application, the highest length of plant obtained on the plants in a year which sewage sludge applied 20 kg m(2) year(-1), the most thickening on body diameter of the plants applied 40 kg m(2) year(-1), the darkest leaf color of the plants applied 60 kg m(2) year(-1). As a result of analysis, it wass determined that nickel and lead have toxic values. When the results are determined; it was found out that it was suitable to use up to 20 kg m(2) year(-1) sewage sludge on L. orientalis and it did not cause any harm on this species

Effects of cyclosporin A and ibuprofen on liver ischemia-reperfusion injury in the rat

Liver ischemia followed by reperfusion is an important and common clinical event associated with the activation of an endogenous inflammatory response. The aim of this study was to determine the effects of cyclosporin A (CsA) and ibuprofen (IBU) on ischemia-reperfusion injury. Male Spraque-Dawley rats were subjected to 60 min of total liver ischemia followed by 120 min reperfusion. Liver tissue samples were obtained for measurements of malondialdehyde (MDA) levels as an index of tissue lipid peroxidation by thiobarbituric acid assay. Three groups of animals were pre-treated with CsA or IBU or both. Treatment with these agents was given at onset reperfusion after ischemia. The other groups were designated as ischemic controls, non-ischemic controls and reperfusion group without treatment. Ischemic control animals showed increased liver MDA levels and in the reperfusion group MDA levels were significantly higher than ischemic levels. CsA and IBU-treated animals had better survival and diminished liver MDA levels. The most significant decrease MDA levels was observed in the group treated with two agents which were given together. Serum enzyme levels were significantly higher in the reperfusion group than in the ischemic controls and the enzyme levels were significantly diminished after the treatments. This study suggests that CsA and IBU may be important agents in modulating lipid peroxidation in ischemia-reperfusion liver injury, and combined therapy with these agents may be more effective in treatment of ischemia-reperfusion injury, (C) 1998 Elsevier Science B.V. All rights reserved

The effect of antioxidant therapy on cell-mediated immunity following burn injury in an animal model

Although antioxidant therapy has been introduced into early post burn protocols to prevent oxidative injury, it is still not known how they effect the cellular immunity which was already depressed due to thermal injury. To investigate the effect of antioxidant therapy on postburn immunosuppression following burn injury in a rat model, well known antioxidants: allopurinol (50 mg/kg/day), desferrioxamine (15 mg/kg/day), PEG-catalase (PEG-CAT) (1200 U/kg/day), N-acetylcysteine (NAS) (1 mg/kg/day) and vitamin-C (Vit-C) (0.5 mg/kg/day) were given for 7 days following thermal injury

Effects of N-acetylcysteine on lung glutathione levels in rats after burn injury

This sturdy ws designed to determine the effect of N-acetylcysteine (NAG, a natural hydroxyl radical scavenger) treatment an levels of pulmonary malondialdehyde (MDA, file end product of lipid peroxidation) and glutathione (GSH, a natural antioxidant) in thermally injured rats. Severe skill scald injury (30 percent TBSA) caused a significant decrease in GSH levels, and a significant increase in MDA levels ill lung tissue both at 1 h and 1 day postburn injury

Augmentation of the columella-labial angle to prevent the "Smiling deformity" in rhinoplasty

Aesthetic diagnosis of the smiling deformity, which is functional rather than anatomical, is essential to provide the best treatment in rhinoplasty. The nasal tip tends to rotate inferiorly during smiling, and the central upper lip moves superiorly. A posteriorly sloping upper lip with a retrodisplaced columella-labial junction gives an unaesthetic appearance. Downward movement of the tip and a sharper nasolabial angle are usually aesthetically unpleasant. In 28 nasal surgeries, augmentation of the columella-labial angle with cartilage strip grafts has been performed. The augmentation of the angle and additionally cutting of the depressor septi muscle created a wider nasolabial complex, and this angle looks full and more pleasant. This procedure has mainly been used as an additional procedure to standard reduction rhinoplasty in order to improve smiling deformity. Strip cartilage grafts were inserted subcutaneously into the upper lip extending half way to the columella and secured with a transcutaneous suture under the columella labial angle to prevent misslocation. Augmentation by the cartilage graft together with cutting the depressor septi muscle prevented elevation and shortening of the upper lip, and also drooping of the nasal tip. This procedure provided an aesthetically pleasant appearance both at rest and during smiling

Mandibular Metastases of Papillary Thyroid Carcinoma Treated by Hemimandibulectomy and Costochondral Rib Graft

Papillary thyroid carcinoma (PTC) is the most common and well-differentiated cancer of the thyroid. Unlike most cancers, spread to local lymph node does not worsen the survival rate of PTC, and complete resection of the metastases seems to be important and may have favorable effects on the prognosis. A 33-year-old woman was referred to our clinic with a mass involving the right angulus mandible. Incisional biopsy of the mass diagnosed follicular variant of papillary thyroid carcinoma. Right hemimandibulectomy was performed and reconstructed with costochondral rib graft. The patient survived for 5 years after the hemimandibulectomy. Metastases to the oral cavity indicate a grave prognosis, but PTC has relatively indolent biological behavior; long-term survival is usually possible even in patients with metastatic disease