Artikain Difüzyon Hacminin Manyetik Rezonans Görüntüleme Yöntemi İle İn Vivo Olarak Değerlendirilmesi

Amaç: İn vivo olarak artikain solüsyonunun difüzyon hacminin manyetik rezonans görüntüleme yöntemi ile değerlendirilmesi ve adrenalin miktarının ve enjeksiyon bölgesinin artikainin difüzyon hacmi üzerine etkisinin belirlenmesidir. Gereç ve Yöntem: Otuz gönüllüye birinci premolar (15 gönüllü) veya birinci molar (15 gönüllü) diş bölgesine bilateral olarak maksiller bukkal supraperiostal enjeksiyon 1:100.000 oranında (1.7 ml) ve 1:200.000 oranında (1.7 ml) adrenalin içeren % 4’lük artikain solüsyonu kullanılarak uygulanmıştır. Manyetik rezonans görüntüleri enjeksiyondan önce ve enjeksiyondan 5 dakika sonra elde edilmiştir. Lokal anestezik solüsyonun difüzyon hacmi planimetri metodu ve Cavalieri prensibi kullanılarak hesaplanmıştır. İstatistiksel analiz Student t testi kullanılarak yapılmıştır. Bulgular: Artikain solüsyonun ortalama difüzyon hacmi 3.23 cm3 olarak hesaplanmıştır. Adrenalin miktarının ve enjeksiyon lokalizasyonunun difüzyon hacmi üzerindeki etkisinin istatistiksel olarak önemli olmadığı görülmüştür (P>0.05). Sonuç: Artikainin 5 dakikalık bekleme süresi sonunda enjekte edilen solüsyon hacminin yaklaşık iki katı büyüklükteki dokuya difüze olabildiği görülmüştü

A longitudinal study on lung disease in dental technicians: What has changed after seven years?

Objectives: The aim of this 7-year follow-up study was to determine respiratory changes in dental technicians. Material and Methods: In our region, in the year 2005, 36 dental technicians were evaluated with a cross-sectional study on respiratory occupational diseases, and in 2012 we evaluated them again. Inclusion of information on respiratory symptoms and demographic features questionnaires was applied. Pulmonary function tests (PFT) were performed. Chest X-rays (CXR) were evaluated according to the ILO-2000 classification. For the comparisons of the technicians' findings in 2005 and 2012, data analyses were performed with the Wilcoxon test in addition to descriptive statistical procedures. Results: In 2012, 19 out of the 36 technicians continued to work in the same place, so we were able to evaluate their findings. The prevalence of respiratory symptoms in dental technician was as follows: dyspnea 7 (37%), cough 6 (32%), and phlegm 5 (26%). According to ILO classifications in 2005, among the 36 technicians, 5 (13.8%) had pneumoconiosis. At the end of 7 years, there were 9 pneumoconiosis cases among the 19 remaining technicians (47%). Thus, there was a statistically significant progression on the profusion of the radiologic findings (p < 0.005). Also there was a significant worsening on spirometric findings (p < 0.05). Conclusion: In dental technicians, a determination of both radiologic and functional progressions at the end of 7 years demonstrate that the primary and secondary preventive measures are necessary for these workplaces. Workplaces must be regularly controlled for worker health and hygiene

CT Assessment of Bone Remodeling in the Otic Capsule in Chronic Renal Failure: Association With Hearing Loss

OBJECTIVE. Hearing loss (HL) is common in patients with chronic renal failure (CRF), but its cause is controversial. The aim of this study was to determine the effect of CRF on the bone density of the otic capsule using densitometric measurements with MDCT and to evaluate the relationship between changes in the otic capsule density and HL in patients with CRF

Importance of Multi-Slice Computed Tomography for Autopsy: Single Center Experience

Virtopsy applications are widely-used minimally invasive autopsy techniques which are assistive techniques to increase the efficacy of the autopsy. The aim of this study was to show whether or not Multi-Slice Computed Tomography (MSCT) could be an alternative autopsy method or used in place of autopsy in some cases. In this study, evaluation was made of 20 forensic cases with MSCT applied pre-autopsy followed by conventional autopsy at Sivas Cumhuriyet University Hospital between 08.11.2006 and 30.09.2007. The cases were 17 male and three female in an age range of four months to 69 years. The cause of death was stated for all except one case, which was in an advanced stage of decomposition. The findings of the MSCT taken before the autopsy were compared with the conventional autopsy findings and the place of virtopsy in forensic cases was discussed. When it is considered that autopsy is necessary in some cases, it can be said that for some, MCST is superior to autopsy, so in some cases it could be an alternative or a supplementary method. Examination made with radiological imaging, as an independent, objective non-invasive observer means that data related to the corpse can be retrieved from digital storage and provides the opportunity for re-examination years after the organ remains have decomposed or been discarded. [Med-Science 2015; 4(1.000): 2039-56

A longitudinal study on lung disease in dental technicians: What has changed after seven years?

Objectives: The aim of this 7-year follow-up study was to determine respiratory changes in dental technicians. Material and Methods: In our region, in the year 2005, 36 dental technicians were evaluated with a cross-sectional study on respiratory occupational diseases, and in 2012 we evaluated them again. Inclusion of information on respiratory symptoms and demographic features questionnaires was applied. Pulmonary function tests (PFT) were performed. Chest X-rays (CXR) were evaluated according to the ILO-2000 classification. For the comparisons of the technicians' findings in 2005 and 2012, data analyses were performed with the Wilcoxon test in addition to descriptive statistical procedures. Results: In 2012, 19 out of the 36 technicians continued to work in the same place, so we were able to evaluate their findings. The prevalence of respiratory symptoms in dental technician was as follows: dyspnea 7 (37%), cough 6 (32%), and phlegm 5 (26%). According to ILO classifications in 2005, among the 36 technicians, 5 (13.8%) had pneumoconiosis. At the end of 7 years, there were 9 pneumoconiosis cases among the 19 remaining technicians (47%). Thus, there was a statistically significant progression on the profusion of the radiologic findings (p < 0.005). Also there was a significant worsening on spirometric findings (p < 0.05). Conclusion: In dental technicians, a determination of both radiologic and functional progressions at the end of 7 years demonstrate that the primary and secondary preventive measures are necessary for these workplaces. Workplaces must be regularly controlled for worker health and hygiene

Tumoral tissue specific promoter hypermethylation of distinct tumor suppressor genes in a case with non--small cell lung carcinoma: A case report

Objective: Non-small cell lung carcinoma is an aggressive phenomenon and the epigenetical alterations of some tumor supressor genes have been reported for the different tumor types. Case Presentation: It is presented a case report concerning a 43 years old male with NSCLC on the lower segment of the right lung. The patient underwent a diag-nostic excisional thin-needle biopsy and after the histological confirmation. We examined the promoter methylation status of some distinct tumor supressor genes in tumoral and blood tissues of the case after sodium bisulfite conversion and DNA amplification with methylation specific multiplex PCR technique. Both tissues were also searched for G to A transitions in codons 12 and 13 of the K-ras proto-oncogene. Results: Tumor specimen showed fully methyl pattern profiles for the SFRP2, p16, DAPK1 and partially hyper-methylated profile for the p53 and MGMT genes in this case with non-small lung carci-noma. Blood speicemen showed normal hypomethylated profiles for all studied TS genes. The K-ras proto-oncogene was in normal structure both in blood and tumoral spiecemens that examined. Conclusion: Results indicate that genes exhibit tumor suppressor activi-ties in blood, but exhibit epigenetic inactivation in carcinoma cell. These findings strongly support the hypothesis that epigenetic mechanisms may play an important role in the non-small cell lung carcinogenesis in human