Identification of the human BetaA2 crystallin gene (CRYBA2) : localization of the gene on human chromosome 2 and of the homologous gene on mouse chromosome 1

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Fine localization of the Nijmegen Breakage Syndrome gene at 8q21: Evidence for a common founder haplotype

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The Postcolonial Citizen: The Intellectual Migrant

The twentieth century has witnessed the rise of a large population of postcolonial intellectual migrants willingly arriving from formerly colonized countries into the United Kingdom, the United States, and Canada to pursue intellectual goals. Embedded in this movement from the formerly colonized spaces into the West is the vexed question of dislocation and displacement for these intellectual subjects. The Postcolonial Citizen traces how such modes of (un)belonging are represented within literary and cultural space and how migrancy, and in particular the postcolonial intellectual migrant, is symbolically and philosophically understood as a cultural icon of displacement in the West. Using literary texts, autobiographical narrative of displacement, and cultural criticism, this book treats the cultural reception of intellectual migrancy (particularly within America) as both an uneasy and ambiguous condition. What is timely about this book\u27s treatment of migrancy is the current threat imposed on postcolonial writers and scholars in the United States post-9/11. The book examines and exposes the consequences of intellectually intervening into democratic ideals after the rise of the national security state - giving the migrant sensibility of dislocation a socio-political dimension. Thus, in dealing with the cultural reception of migrancy, The Postcolonial Citizenclearly marks the shift between pre- and post-9/11 migrant subjectivity and particularly addresses how the third world intellectual migrant has become synonymous with the voice of dissent and threat to the established democratic order in the United States.https://digitalcommons.linfield.edu/linfauth/1003/thumbnail.jp

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

Nijmegen breakage syndrome (NBS) is an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Cells from NBS patients are hypersensitive to ionizing radiation with cytogenetic features indistinguishable from ataxia telangiectasia. We describe the positional cloning of a gene encoding a novel protein, nibrin. It contains two modules found in cell cycle checkpoint proteins, a forkhead-associated domain adjacent to a breast cancer carboxy-terminal domain. A truncating 5 bp deletion was identified in the majority of NBS patients, carrying a conserved marker haplotype. Five further truncating mutations were identified in patients with other distinct haplotypes. The domains found in nibrin and the NBS phenotype suggest that this disorder is caused by defective responses to DNA double-strand breaks