44 research outputs found
Reverse Engineering and FEM Analysis for Mechanical Strength Evaluation of Complete Dentures: A Case Study
RESEARCH ON THE CHOICE OF ECOPRODUCTIVE TECHNOLOGIES OF FOREST HARVESTING IN THE NATIONAL PARK OF SEMENIC - CHEILE CARAŞULUI
The current paper addresses the issue of choosing ecoproductive technologies of forest harvesting in the National Park of Semenic - Cheile Carasului, both through the optimal choice of the method of operation and through the system of machines used for forest harvesting from the economic, ecological and ergonomic point of view. Subsequent to the presentation of the materials and methods used, different methods of harvesting are compared in the context of ecoproductive exploitation. The selected optimal method was examined by means of a SWOT analysis through highlighting its advantages and disadvantages. After choosing the method of harvesting, the effective application of technologies of reduced environmental impact took place by choosing the optimal machine systems
RESEARCH ON THE ASSORTMENT OF THE TIMBER HARVESTED IN THE FOREST DISTRICT OF ANINA IN 2014
The paper addresses a topical issue in the analysis and comparison of results from forest harvesting in 4 lots within the Forest Distict of Anina, by methods of calculation and final measurement result in the warehouse. The research was conducted in the Forest District of Anina in the timber harvesting areas operated by logging services in 4 lots in 2014. After presenting the need, goals and objectives, the paper focuses on the research methods used and the procedure related to the determination of the industrial assortments though different methods, whose outcomes are then compared
An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-β
A key hallmark of Alzheimer’s disease is the extracellular deposition of amyloid plaques composed primarily of the amyloidogenic amyloid-β (Aβ) peptide. The Aβ peptide is a product of sequential cleavage of the Amyloid Precursor Protein, the first step of which gives rise to a C-terminal Fragment (C99). Cleavage of C99 by γ-secretase activity releases Aβ of several lengths and the Aβ42 isoform in particular has been identified as being neurotoxic. The misfolding of Aβ leads to subsequent amyloid fibril formation by nucleated polymerisation. This requires an initial and critical nucleus for self-assembly. Here, we identify and characterise the composition and self-assembly properties of cell-derived hexameric Aβ42 and show its assembly enhancing properties which are dependent on the Aβ monomer availability. Identification of nucleating assemblies that contribute to self-assembly in this way may serve as therapeutic targets to prevent the formation of toxic oligomers