Cerámicas griegas arcaicas de inspiración eolia manufacturadas en Huelva, España

Greeks settled in the ancient emporium of Huelva manufactured archaic gray pottery inspired by Aeolian prototypes. Results of Neutron Activation Analysis showed that seven out of 11 specimens analyzed had a chemical composition similar to the loamy clay from local deposits traditionally used in pottery. This gray pottery must have found a good acceptance not only among the resident Greeks, but also among the non-Greek population long before familiarized with the so called “orientalizing gray pottery”, whose coloration and production by reduction firing are similar to the Aeolian one. In the same settlement, two other groups of archaic Greek pottery manufactured in situ had already been identified: one of them characterized by a yellowish-green paste and the other one, conventionally named “Group H”, decorated with red slips comparable to the Phoenician ceramics.Los griegos establecidos en el antiguo emporio de Huelva manufacturaron cerámicas grises arcaicas inspiradas en prototipos eolios. Los análisis por activación neutrónica demostraron que siete de 11 especímenes analizados tenían una composición similar a las arcillas margosas de los depósitos locales tradicionalmente utilizadas en la industria alfarera. Estas cerámicas grises debieron encontrar una buena recepción no solo entre los griegos residentes, sino también entre la población no griega del emporio familiarizada desde mucho antes con la denominada “cerámica gris orientalizante”, de similar coloración y producción por cocción reductora que las eolias. En el mismo asentamiento habían sido identificados otros dos grupos de cerámicas griegas arcaicas manufacturadas in situ: uno caracterizado por una pasta verdosa amarillenta y otro, convencionalmente denominado “Grupo H”, decorado mediante engobes rojos como los fenicios

Two compound heterozygous variants in the CLN8 gene are responsible for neuronal cereidolipofuscinoses disorder in a child: a case report

BackgroundNeuronal Ceroid Lipofuscinosis (NCL) disorders, recognized as the primary cause of childhood dementia globally, constitute a spectrum of genetic abnormalities. CLN8, a subtype within NCL, is characterized by cognitive decline, motor impairment, and visual deterioration. This study focuses on an atypical case with congenital onset and a remarkably slow disease progression.MethodsWhole-genome sequencing at 30× coverage was employed as part of a national genomics program to investigate the genetic underpinnings of rare diseases. This genomic approach aimed to challenge established classifications (vLINCL and EPMR) and explore the presence of a continuous phenotypic spectrum associated with CLN8.ResultsThe whole-genome sequencing revealed two novel likely pathogenic mutations in the CLN8 gene on chromosome 8p23.3. These mutations were not previously associated with CLN8-related NCL. Contrary to established classifications (vLINCL and EPMR), our findings suggest a continuous phenotypic spectrum associated with CLN8. Pathological subcellular markers further validated the genomic insights.DiscussionThe identification of two previously undescribed likely pathogenic CLN8 gene mutations challenges traditional classifications and highlights a more nuanced phenotypic spectrum associated with CLN8. Our findings underscore the significance of genetic modifiers and interactions with unrelated genes in shaping variable phenotypic outcomes. The inclusion of pathological subcellular markers further strengthens the validity of our genomic insights. This research enhances our understanding of CLN8 disorders, emphasizing the need for comprehensive genomic analyses to elucidate the complexity of phenotypic presentations and guide tailored therapeutic strategies. The identification of new likely pathogenic mutations underscores the dynamic nature of CLN8-related NCL and the importance of individualized approaches to patient management

La explotación tartésica de la casiterita entre los ríos Tajo y Guadiana: San Cristóbal de Logrosán (Cáceres)

The objective of this work is to offer a synthesis of the archaeological and archaeo-mining investigation carried out in recent years (1998 and 2000-2002) in the Cerro de San Cristobal site, Logrosán (Cáceres). The results allow us to propose a chaîne opératoire for the cassiterite treatment and use in Cerro de San Cristóbal during the transition from the Late Bronze Age to the Orientalizing period. The management and role of this mineral in the Tajo-Guadiana relations and in the Atlantic- Mediterranean circuits meeting in the Southwest of the Iberian Peninsula, together with other factors, seems to justify the early integration of the territory of Extremadura in Tartessos. The investigation in Logrosán and the archaeology of tin were suddenly interrupted by the unexpected death of its main promoter, Dr. Craig Merideth. The continuation of this project is now to be channelled through the recent declaration of the Cerro de San Cristobal as a ‘geosite’ in the ‘Ibores-Villuercas- Jara Geopark’ and through the National Research, Development and Innovation Scheme’s project <i>El tiempo del tesoro de Aliseda</i>, among whose actions is the archaeomining survey from the West of the peneplain of Cáceres made in 2011.<br><br>El objetivo de este trabajo es ofrecer una síntesis de la investigación arqueológica y arqueominera realizada entre 1998 y 2000-2002 en el Cerro de San Cristóbal de Logrosán (Cáceres). Esta permite proponer una probable ‘cadena operativa’ del beneficio de la casiterita en este lugar durante el tránsito Bronce Final-Periodo Orientalizante. La gestión e imbricación del mineral en las relaciones Tajo-Guadiana y en los circuitos atlántico-mediterráneos confluyentes en el Suroeste de la Península Ibérica parecen justificar, entre otras razones, la temprana integración del actual territorio extremeño en Tartessos. La investigación en Logrosán y la arqueología del estaño se vieron bruscamente interrumpidas por el inesperado fallecimiento de su principal impulsor, Craig Merideth. Su continuidad pretende canalizarse a través de la reciente declaración del Cerro de San Cristóbal como “geositio” del Geoparque “Ibores-Villuercas-Jara” y del proyecto del Plan Nacional I+D+i <i>El tiempo del tesoro de Aliseda</i>, entre cuyas acciones se encuentra la prospección arqueominera del oeste de la penillanura cacereña realizada en 2011

Investment-Specific Productivity Growth: Chile from a Global Perspective

By the end of 2007, Chile’s total factor productivity was lower than ten years earlier, a performance that contrasted sharply with the previous decade, when productivity grew by a cumulative 30 percent. This paper assesses productivity trends in Chile, by decomposing productivity into investment-specific technological change (associated with improvements in the quality of capital) and neutral technological change (related to the organization of productive activities). It concludes that investment-specific technological improvements have contributed significantly to long-term growth in Chile, in line with trends observed in other net commodity exporters, while neutral technological change has been slow.