Predicción de bancarrota: Una comparación de técnicas estadísticas y de aprendizaje supervisado para computadora

We are interested in forecasting bankruptcies in a probabilistic way. Specifcally, we com- pare the classification performance of several statistical and machine-learning techniques, namely discriminant analysis (Altman's Z-score), logistic regression, least-squares support vector machines and different instances of Gaussian processes (GP's) -that is GP's classifiers, Bayesian Fisher discriminant and Warped GP's. Our contribution to the field of computa- tional finance is to introduce GP's as a potentially competitive probabilistic framework for bankruptcy prediction. Data from the repository of information of the US Federal Deposit Insurance Corporation is used to test the predictions

Predicción de bancarrota: Una comparación de técnicas estadísticas y de aprendizaje supervisado para computadora

We are interested in forecasting bankruptcies in a probabilistic way. Specifcally, we com- pare the classification performance of several statistical and machine-learning techniques, namely discriminant analysis (Altman's Z-score), logistic regression, least-squares support vector machines and different instances of Gaussian processes (GP's) -that is GP's classifiers, Bayesian Fisher discriminant and Warped GP's. Our contribution to the field of computa- tional finance is to introduce GP's as a potentially competitive probabilistic framework for bankruptcy prediction. Data from the repository of information of the US Federal Deposit Insurance Corporation is used to test the predictions

Effects of adult temperature on gene expression in a butterfly: identifying pathways associated with thermal acclimation

Abstract Background Phenotypic plasticity is a pervasive property of all organisms and considered to be of key importance for dealing with environmental variation. Plastic responses to temperature, which is one of the most important ecological factors, have received much attention over recent decades. A recurrent pattern of temperature-induced adaptive plasticity includes increased heat tolerance after exposure to warmer temperatures and increased cold tolerance after exposure to cooler temperatures. However, the mechanisms underlying these plastic responses are hitherto not well understood. Therefore, we here investigate effects of adult acclimation on gene expression in the tropical butterfly Bicyclus anynana, using an RNAseq approach. Results We show that several antioxidant markers (e.g. peroxidase, cytochrome P450) were up-regulated at a higher temperature compared with a lower adult temperature, which might play an important role in the acclamatory responses subsequently providing increased heat tolerance. Furthermore, several metabolic pathways were up-regulated at the higher temperature, likely reflecting increased metabolic rates. In contrast, we found no evidence for a decisive role of the heat shock response. Conclusions Although the important role of antioxidant defence mechanisms in alleviating detrimental effects of oxidative stress is firmly established, we speculate that its potentially important role in mediating heat tolerance and survival under stress has been underestimated thus far and thus deserves more attention

Genome-wide chromatin and gene expression profiling during memory formation and maintenance in adult mice. [CODE: support files]

This repository contains annotation files for mouse genome assembly mm10, including chromosome sizes, gene and exon annotations, mappability file and the R package chequeR used to generate enrichment statistics for ChIP-seq data. The files are used in the analyses of ChIP-, MeDIP- and RNA-seq data from mouse, as described by the run_scientific_data_analysis.pdf in the scripts repository (https://dx.doi.org/10.6084/m9.figshare.3490613)<br

Genome-wide chromatin and gene expression profiling during memory formation and maintenance in adult mice. [Data Record 6: DHPTMs]

<b><u>DESCRIPTION</u></b><br>This data record contains tables of all differential histone post-translational modifications (DHPTMs), where each table contains different compared conditions for time point 1h, tissue CA1, and each cell type (Neu or Non) and histone mark (H3K27AC, H3K27ME3, H3K4ME1, H3K4ME3, H3K79ME3 or H3K9AC). Each mark is analysed for different DHPTM region set, where H3K27ac and H3K4me1 are analysed for peak regions, H3K27me3 and H3K79me3 are analysed for gene bodies and H3K4me3 and H3K9ac are analysed for TSS regions [-500,+1000] bases around the TSS. The compared conditions concern the different sets of mouse, N-C compares naïve (N) to context (C) mice, N-CS compares naive (N) to context shock (CS) mice, and C-CS compares context (C) to context shock (CS) mice.<br><br><b><u>TABLES</u></b><br>The table contains columns with HPTM coordinates and differential occupation statistics. Columns “chromosome”, “DHPTM start”, “DHPTM end” and “Strand” contain the position in the genome where the DHPTM was detected (mm10 assembly), where peak-based tests (marks H3K27ac and H3K4me1) were run as strand-independent, so for such tests column “Strand” contains “.” for all entries. Column “baseMean” shows the average normalised read counts in each DHPTM. Column “logFC” shows the fold change of the comparison between the conditions in log 2. Columns “pvalue” and “p-adjust” contain the pvalue and the adjusted p-value according to the FDR test.<br><br><u><b>DATA GENERATION</b></u><br>The code used to identify DHPTMs can be found in Figshare (https://dx.doi.org/10.6084/m9.figshare.3153400).<br><br

RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment

Summary: Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer’s disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific miRs as candidates mechanistically involved in this type of transmission. : Environmental enrichment (EE), a combination of physical and mental exercise, has been shown to increase cognitive abilities in mice and in humans. Benito et al. find that offspring of male mice subjected to EE also show this increase. This effect is dependent on sperm RNA and involves microRNA212/132. Keywords: epigenetics, brain, microRNA, memory, intergenerational, transgenerational, exercise, environmental enrichment, cognitio

Genome-wide chromatin and gene expression profiling during memory formation and maintenance in adult mice. [Data Record 6: RNA-seq]

<u><b>DESCRIPTION<br></b>Experiment type</u> - Expression profiling by high throughput sequencing<br><u>Design</u> - Gene and exon expression changes in two distinct mouse brain regions (CA1, ACC) and three time-points (00H for naive, 01H for 1 hour, 04W for 4 weeks) before and after contextual learning (NAI for naive, CON for context, SHC for context shock).<br><br><b><u>DATA REPOSITORIES</u></b><br><u>EPIGENOME BROWSER (https://memory-epigenome-browser.dzne.de/)</u><br>Contains RNA-seq data under category "RNASEQ-DATA". Sample names include conditioning, time-point, tissue and replicate number (1 to 5; samples without numbers are merged replicates) separated by dashes. bigWig files can also be downloaded for local visualisation.<br><u>Gene Expression Omnibus (GEO)</u><br>Data is available on GEO under the accession number GSE74966 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE74966), containing SRA and bigwig files to download for all 29 RNA-seq samples.<br><br><b><u>DATA GENERATION</u></b><br>Alignment and visualisation data was generate using the pre-processing code found in Figshare (https://dx.doi.org/10.6084/m9.figshare.3153193).<br><u><b><br></b></u

Lindsaea orbiculata Mett.

原著和名: エダウチホングウシダ科名: ホングウシダ科 = Lindsaeaceae採集地: 三重県 尾鷲市 (紀伊 尾鷲市)採集日: 1962/11/1採集者: 萩庭丈壽整理番号: JH043649国立科学博物館整理番号: TNS-VS-99364

Genome-wide chromatin and gene expression profiling during memory formation and maintenance in adult mice. [CODE: Pre-processing]

This repository contains the scripts and files used to generate the alignment files used for downstream analyses, the bigWig files used to visualise the data and various Quality Control (QC) results used to address the quality of the various samples.<br><div><br></div><div>The complete details about the various scripts and files in this repository, as well as the set of commands used to run the analysis, are included in the file README.txt</div

Genome-wide chromatin and gene expression profiling during memory formation and maintenance in adult mice. [CODE: CRMs]

This repository contains the positive and negative training sets generated from the ChIP-seq transcription factor and histone post-translational modification data. Such sets of data were run as input to the RFECS software. RFECS is a tailor-made random forest model for making cis-regulatory module (CRM) predictions. The random forest model used for making the predictions is also available in this repository as a binary MATLAB file.<div><br></div><div>The references below explain specifically how to (1) access a MATLAB file and (2), how to use the current model file to predict the CRMs. For more details about the RFECS algorithm itself, take a look at reference (3).<br></div