Manejo práctico de una crisis asmática

15 páginas.Capítulo incluido en el libro: Actualización en alergología para médicos de atención primaria. Manuel Alcántara Villar (Coordinador). Sevilla: Universidad Internacional de Andalucía, 2018. ISBN 978-84-7993-340-1. Enlace: http://hdl.handle.net/10334/3910

Manejo actual del paciente con asma grave mal controlado

13 páginas.Capítulo incluido en el libro: Hacia un mejor control de nuestros pacientes con asma. Manuel Alcantara Villar (Coordinador). Sevilla: Universidad Internacional de Andalucía, 2019. ISBN 978-84-7993-351-7. Enlace: http://hdl.handle.net/10334/4035

Aportación del análisis semicuantitativo (SUV Máximo) de la imagen 18 F-FDG-PET como factor pronóstico en el carcinoma pulmonar no microcítico

Tesis Univ. Granada. Departamento de Radiología y Medicina Interna. Leída el 1 de julio de 200

Asma grave no controlado : nuevos horizontes terapéuticos de futuro

págs. 201-214.Capítulo incluido en el libro: Nuevas fronteras en el tratamiento de las enfermedades alérgicas respiratorias. Manuel Alcántara Villar (coordinador). Sevilla: Universidad Internacional de Andalucía, 2016. ISBN: 978-84-7993-317-3. Enlace: http://hdl.handle.net/10334/367

Uso correcto de inhaladores. Hacer fácil lo difícil

18 páginas.Capítulo incluido en el libro: Formación práctica en alergología para médicos de atención primaria. Manuel Alcántara Villar (Coordinador). Sevilla: Universidad Internacional de Andalucía, 2017. ISBN: 978-84-7993-334-0. Enlace: http://hdl.handle.net/10334/383

Early use of tocilizumab in patients with severe pneumonia secondary to severe acute respiratory syndrome coronavirus 2 infection and poor prognostic criteria: Impact on mortality rate and intensive care unit admission.

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2, keeps spreading globally. Evidence suggests that a subgroup of patients with severe symptomatology might have cytokine storms, which increases mortality. The use of interleukin-6 (IL-6) inhibitors may help in controlling the pathological immune response to the virus. Tocilizumab, a monoclonal antibody against IL-6, stands as an optional treatment for COVID-19 patients presenting this inflammatory hyper-response.We conducted a retrospective, observational, cohort study including 50 patients affected by COVID-19 with severe pneumonia and poor prognosis criteria, who have also undergone standard treatment; 36 of these patients additionally received tocilizumab in an early stage. The need for intensive care unit (ICU) admission, mortality, recovery of respiratory function, and improvement of biochemical and hematological parameters were compared between cohorts.Most patients were men, non-smokers and the most frequently reported comorbidities were hypertension and diabetes. Recurrent symptoms were fever, cough, and dyspnoea. 54.8% of patients from the tocilizumab group needed intubation, while in the control group 85.7% needed it. Treatment with tocilizumab significatively increased IL-6 levels, (554.45; CI 95% 186.69, 1032.93; P

Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease

Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC