84 research outputs found
The psychosocial burden of hidradenitis suppurativa: the patients' perspectives
We designed a qualitative study to interview 12 patients with Hidradenitis Suppurativa. This was done by means of a semistructured interview. Questions on quality of life, the impact of their skin disease on family, friends, work, intimate relationships, treatments, etc. were asked. Patients consented to be interviewed and to be video taped to facilitate the transcription of the interviews. The interviews lasted between 30 and 60 minutes and were carried out by a psychologist and a social worker. The dermatologist had previously seen the patients and filled in a form with the Hurley Stage, years of evolution and treatment..
Status of the ANAIS Dark Matter Project at the Canfranc Underground Laboratory
The ANAIS experiment aims at the confirmation of the DAMA/LIBRA signal. A
detailed analysis of two NaI(Tl) crystals of 12.5 kg each grown by Alpha
Spectra will be shown: effective threshold at 1 keVee is at reach thanks to
outstanding light collection and robust PMT noise filtering protocols and the
measured background is well understood down to 3 keVee, having quantified K, U
and Th content and cosmogenic activation in the crystals. A new detector was
installed in Canfranc in March 2015 together with the two previous modules and
preliminary characterization results will be presented. Finally, the status and
expected sensitivity of the full experiment with 112 kg will be reviewed.Comment: Contributed to the 11th Patras Workshop on Axions, WIMPs and WISPs,
Zaragoza, June 22 to 26, 201
Background model of NaI(Tl) detectors for the ANAIS Dark Matter Project
A thorough understanding of the background sources is mandatory in any
experiment searching for rare events. The ANAIS (Annual Modulation with NaI(Tl)
Scintillators) experiment aims at the confirmation of the DAMA/LIBRA signal at
the Canfranc Underground Laboratory (LSC). Two NaI(Tl) crystals of 12.5 kg each
produced by Alpha Spectra have been taking data since December 2012. The
complete background model of these detectors and more precisely in the region
of interest will be described. Preliminary background analysis of a new 12.5 kg
crystal received at Canfranc in March 2015 will be presented too. Finally, the
power of anticoincidence rejection in the region of interest has been analyzed
in a 4x 5 12.5 kg detector matrix.Comment: Contributed to the 11th Patras Workshop on Axions, WIMPs and WISPs,
Zaragoza, June 22 to 26, 201
Production and relevance of cosmogenic radionuclides in NaI(Tl) crystals
The cosmogenic production of long-lived radioactive isotopes in materials is
an hazard for experiments demanding ultra-low background conditions. Although
NaI(Tl) scintillators have been used in this context for a long time, very few
activation data were available. We present results from two 12.5 kg NaI(Tl)
detectors, developed within the ANAIS project and installed at the Canfranc
Underground Laboratory. The prompt data taking starting made possible a
reliable quantification of production of some I, Te and Na isotopes with
half-lives larger than ten days. Initial activities underground were measured
and then production rates at sea level were estimated following the history of
detectors; a comparison of these rates with calculations using typical cosmic
neutron flux at sea level and a selected description of excitation functions
was also carried out. After including the contribution from the identified
cosmogenic products in the detector background model, we found that the
presence of 3H in the crystal bulk would help to fit much better our background
model and experimental data. We have analyzed the cosmogenic production of 3H
in NaI, and although precise quantification has not been attempted, we can
conclude that it could imply a very relevant contribution to the total
background below 15 keV in NaI detectors.Comment: Proceedings of the Low Radioactivity Techniques 2015 workshop, March
2015, Seattle (US
Analysis of backgrounds for the ANAIS-112 dark matter experiment
The ANAIS (Annual modulation with NaI(Tl) Scintillators) experiment aims at
the confirmation or refutation of theDAMA/LIBRA positive annual modulation
signal in the low energy detection rate, using the same target and technique,
at the Canfranc Underground Laboratory (LSC) in Spain. ANAIS-112, consisting of
nine 12.5 kg NaI(Tl) modules produced by Alpha Spectra Inc. in a 3x3matrix
configuration, is taking data smoothly in "dark matter search" mode since
August, 2017, after a commissioning phase and operation of the first detectors
during the last years in various setups. A large effort has been carried out
withinANAIS to characterize the background of sodium iodide detectors, before
unblinding the data and performing the first annual modulation analysis. Here,
the background models developed for all the nine ANAIS-112 detectors are
presented. Measured spectra from threshold to high energy in different
conditions are well described by the models based on quantified activities
independently estimated following several approaches. In the region from 1 to 6
keVee the measured, efficiency corrected background level is 3.58+-0.02 keV-1
kg-1 day-1; NaI crystal bulk contamination is the dominant background source
being 210Pb, 40K, 22Na and 3H contributions the most relevant ones. This
background level, added to the achieved 1 keVee analysis threshold (thanks to
the outstanding light collection and robust filtering procedures developed),
allow ANAIS-112 to be sensitive to the modulation amplitude measured by
DAMA/LIBRA, and able to explore at three sigma level in 5 years the WIMP
parameter region singled out by this experiment.Comment: Final version for publicatio
Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes
Visfatin is an adipokine highly expressed in visceral AT (adipose tissue) of humans and rodents, the production of which seems to be dysregulated in excessive fat accumulation and conditions of insulin resistance. EPA (eicosapentaenoic acid), an n−3 PUFA (polyunsaturated fatty acid), has been demonstrated to exert beneficial effects in obesity and insulin resistance conditions, which have been further linked to its reported ability to modulate adipokine production by adipocytes. TNF-α (tumour necrosis factor-α) is a pro-inflammatory cytokine whose production is increased in obesity and is involved in the development of insulin resistance. Control of adipokine production by some insulin-sensitizing compounds has been associated with the stimulation of AMPK (AMP-activated protein kinase). The aim of the present study was to examine in vitro the effects of EPA on visfatin production and the potential involvement of AMPK both in the absence or presence of TNF-α. Treatment with the pro-inflammatory cytokine TNF-α (1 ng/ml) did not modify visfatin gene expression and protein secretion in primary cultured rat adipocytes. However, treatment of these primary adipocytes with EPA (200 μmol/l) for 24 h significantly increased visfatin secretion (P<0.001) and mRNA gene expression (P<0.05). Moreover, the stimulatory effect of EPA on visfatin secretion was prevented by treatment with the AMPK inhibitor Compound C, but not with the PI3K (phosphoinositide 3-kinase) inhibitor LY294002. Similar results were observed in 3T3-L1 adipocytes. Moreover, EPA strongly stimulated AMPK phosphorylation alone or in combination with TNF-α in 3T3-L1 adipocytes and pre-adipocytes. The results of the present study suggest that the stimulatory action of EPA on visfatin production involves AMPK activation in adipocytes
Profile and reproductive roles of seminal plasma melatonin of boar ejaculates used in artificial insemination programs
Melatonin (MLT) is present in seminal plasma (SP) of mammalian species, including pigs, and it is credited with antioxidant properties. This study aims to identify the sources of variation and the role of boar SP MLT on sperm quality and functionality and in vivo fertilizing ability of liquid-stored semen doses used in AI programs. The SP MLT was measured using an ELISA kit in a total of 219 ejaculates collected from 76 boars, and reproductive records of 5,318 AI sows were recorded. Sperm quality was assessed according to motility (computer-aided sperm analysis) and viability (cytometry evaluation). Sperm functionality was assessed according to the cytometric determination of intracellular H2O2 generation, total and mitochondrial O2- production, and lipid peroxidation in liquid AI semen samples stored at 17°C over 144 h. The concentration of SP MLT differed among seasons (P < 0.01) and day length periods (P < 0.001) of the year, demonstrating that the ejaculates collected during the increasing day length period (9.80 ± 1.38 pg/mL, range: 2.75–21.94) had lower SP MLT concentrations than those collected during the decreasing day length period (16.32 ± 1.67 pg/mL, range: 5.02–35.61). The SP MLT also differed (P < 0.001) among boars, among ejaculates within boar, and among portions within the ejaculate, demonstrating that SP from the first 10 mL of sperm-rich ejaculate fraction (SRF) exhibited lower MLT concentrations than post-SRF. The SP MLT was negatively related (P < 0.001) to mitochondrial O2- production in viable sperm. The SP MLT did not differ among AI boars (n = 14) hierarchically grouped according to high and low fertility outcomes. In conclusion, SP MLT concentration in AI boars varies depending on the season of ejaculate collection and differs among boars, ejaculates within boar, and portions within ejaculate. The SP MLT may act at the mitochondrial level of sperm by reducing the generation of O2-. However, this antioxidant role of SP MLT was not reflected in sperm quality or in vivo fertility outcomes of AI semen doses
Study of scintillation in natural and synthetic quartz and methacrylate
Samples from different materials typically used as optical windows or light
guides in scintillation detectors were studied in a very low background
environment, at the Canfranc Underground Laboratory, searching for
scintillation. A positive result can be confirmed for natural quartz: two
distinct scintillation components have been identified, not being excited by an
external gamma source. Although similar effect has not been observed neither
for synthetic quartz nor for methacrylate, a fast light emission excited by
intense gamma flux is evidenced for all the samples in our measurements. These
results could affect the use of these materials in low energy applications of
scintillation detectors requiring low radioactive background conditions, as
they entail a source of background.Comment: Accepted for publication in Optical Material
- …