Understanding Prognostic Factors for Human Papillomavirus Vaccination: A Rural Community Case–Control Study

HPV vaccination coverage rates can vary depending on several factors. The main objective of this study is to identify possible independent prognostic factors that have an impact on HPV vaccination in a rural community, specifically related to sexual and reproductive health. A case-control, retrospective, community-based study was carried out on women aged 15 to 40 in the primary health centers of Southern Catalonia's Terres de l'Ebre region, Spain, from 1 January 2020 to 31 December 2022. A random sample of 520 women with an average age of 29.3 (SD 7.8) years old was included in the study. Independent prognostic factors: age OR 0.680 (95% CI: 0.635-0.729, p < 0.001), immigrant origin OR 0.215 (95% CI: 0.109-0.422, p < 0.001), and HPV PCR OR 7.402 (95% CI: 2.504-21.880, p < 0.001). The variables that showed a barrier effect for HPV vaccination were age (OR 0.680, 95% CI 0.635-0.729, p < 0.001), and immigrant origin (OR 0.215, 95% CI 0.109-0.422, p < 0.001). The variable that showed a facilitating effect for HPV vaccination was HPV PCR (OR 7.402, 95% CI 2.504-21.880, p < 0.001)

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Sitúate : revista digital de situaciones de aprendizaje

La situación de aprendizaje plantea el conocimiento de los medios de comunicación, en concreto y más en profundidad de la radio. Además, se añade el atractivo de aprender de forma distinta todo lo referente al Romanticismo, utilizando la imaginación para situarse en esa época literaria y realizar un trabajo creativo que presentar ante los demás. En esta tarea están presentes dos puntos que el Proyecto Educativo destaca como prioritarios: la integración en el proceso de enseñanza-aprendizaje de las TIC, que serán necesarias durante toda la secuencia de actividades tanto para el profesorado como para el alumnado; y el trabajo en equipo, como respuesta metodológica a la atención a la diversidad (ayuda diferenciada, no actividades diferenciadas), eje vertebrador de la presente propuesta.ES

HPV Vaccination Coverage Rate in a Rural Area: An Observational, Retrospective, and Cohort Study

In order to reduce the incidence and mortality rate of cervical cancer, the World Health Organization (WHO) declared the Global Strategy Goal for 2030, advocating for reaching a vaccination coverage rate of &gt;90% against human papillomavirus for girls by the age of 15 years. The main objectives of this study were (1) to determine the papillomavirus vaccination coverage among women 15&ndash;40 years old and (2) to identify the at-risk subgroups and possible barriers to achieving WHO&rsquo;s 2030 goal. Multicentre, observational, retrospective, and community-based cohort studies were conducted on women from a rural area in southern Catalonia until 31 December 2021. A total of 23,136 women were included, with a mean age of 26.6 (SD = 5.6) years. The average dose number was 1.7 (SD = 0.7). The results showed overall vaccination coverage of 17.4% among the target women. This coverage was unequal across regions (16.6&ndash;24.5%, p &lt; 0.001), primary healthcare teams (15.5&ndash;24.3%, p &lt; 0.001), and age groups (56.7% (15&ndash;19-year-olds) vs. 3.8% (35&ndash;40-year-olds), p &lt; 0.001), related to accessibility to vaccination and economic&ndash;geographical indicators. Clinical practice guidelines on screening individuals at risk in terms of vaccination access and public vaccination protocols should be implemented in order to improve the vaccination coverage rate

Analgesic dipeptide derivatives. Part 8. 3-amino-2-hydroxy-4-[2-(o- nitrophenylthio)indol-3-yl]butanoic acid [AH(NPS)IBA]-containing dipeptide analogues of the analgesic compound H-Trp(Nps)-Lys-OMe

A series of diastereoisomeric dipeptides, analogues of the analgesic compound H-Trp(Nps)-Lys-OMe, containing 3-amino-2-hydroxy-4-[2-(o- nitrophenylthio)indol-3-yl]butanoic acid [AH(Nps)IBA] and Lys or Leu has been synthesized. These compounds were tested as aminopeptidase-M and -B (AP-M and AP-B) inhibitors and as analgesics. The AH(Nps)IBA-Leu dipeptides, independently of their stereochemistry, were poor inhibitors of AP-M and AP-B, with IC 50-values in the 10-4 mol dm-3 range, while the AH(Nps)IBA-Lys derivatives were poor AP-B inhibitors, with IC 50-values also in the 10-4 mol dm-3 range, and did not inhibit AP-M up to 10-3. All the AH(Nps)IBA-Lys derivatives induced a significant dose-related analgesic activity at 1-5 μg per mouse, which was dependent on the stereochemistry, while no analgesia was observed with the corresponding Leu-containing analogues. There is no relationship between the antinociceptive effects and the AP-M inhibitory potencies of this series of compounds, indicating that the inhibition of enkephalin-degrading AP-M is not an important factor for the mode of action of this series of analgesic dipeptides.Peer Reviewe

Ketomethylene analogues of phosphoryl dipeptides related to phosphoramidon: Synthesis and inhibition of proteases

Non-rhamnose-containing phosphoramidon analogues, in which the amide bond was replaced by the isosteric ketomethylene group, have been synthesized in order to stabilize these compounds to peptidase degradation. The key step in this synthesis was suitable alkylation of a 4-ketodiester, prepared from Z-Leu chloromethyl ketone and dimethyl malonate. The ketomethylene dipeptide derivatives P-Leu Ψ(COCH2)(RS)Xaa-OMe (Xaa = Trp, Phe) are good inhibitors of thermolysin, ACE and specially enkephalinase

Analgesic dipeptide derivatives. 7. 3,7-Diamino-2-hydroxyheptanoic acid (DAHHA) containing dipeptide analogues of the analgesic compound H-Lys- Trp(Nps)-OMe

A series of diastereomeric dipeptides, analogues of the analgesic compound H-Lys-Trp(Nps)-OMe (2), containing 3,7-diamino-2-hydroxyheptanoic acid (DAHHA) and 2-[(o-nitrophenyl)sulfenyl]tryptophan [Trp(Nps)] has been synthesized. These compounds were tested as enkephalin-degrading aminopeptidases (APs), AP-M and AP-B inhibitors, and analgesics. The inhibitory potencies and the antinociceptive effects depended on the stereochemistry of the compounds. (2S,3R)-DAHHA-L-Trp(Nps)-OMe (26d) was a highly potent and selective enkephalin-degrading APs inhibitor, with an IC50 value in the 10-8 M range. Although this derivative was about 103- fold more potent than 2 against these enzymes, their antinociceptive effects were completely similar. These results indicate that the inhibitory capacity of this series of Trp(Nps)-containing dipeptides against enkephalin-degrading enzymes is not an important factor for their antinociceptive effects.The present work has been sup-ported by Comisión Interministerial de Ciencia y Tecnología (Plan Nacional Project FAR88-0298)

Aminopeptidase inhibitory properties and analgesic activity of (2S,3R)-3,7-diamino-2-hydroxy-heptanoic acid containing tripeptide analogues of the N-terminal tripeptide of probestin

(2S,3R)-3,7-Diamino-2-hydroxy-heptanoyl-Leu-Pro-OH [(2S,3R)-DAHHA-Leu-Pro-OH, 4], analogue of the N-terminal tripeptide of probestin, has been synthesized, and tested as inhibitor of AP-B, Leu-AP, AP-M, and enkephalin-degrading APs, and as analgesic. In order to establish structure-activity relationships the dipeptide (2S,3R)-DAHHA-Pro-OH (5) and the tripeptide (2S, 3R)-DAHHA-Ala-Pro-OH (6) were also prepared. Compounds 4 and 6 were potent and selective inhibitors of enkephalin-degrading APs and showed a prolonged antinociceptive effect

La sonrisa de un niño autista : una boca saludable

Incluye vídeo, fichas de análisis y de evaluación.El proyecto surge como consecuencia del programa de salud buco-dental del Ayuntamiento, realizado el curso anterior. Los objetivos son fomentar la adquisicion de hábitos y actitudes relacionadas con la higiene, el bienestar y la salud dental; desarrollar las destrezas cognitivas y de atención para favorecer la percepción de cambios y el conocimiento de las partes del cuerpo; aumentar la competencia comunicativa; mejorar funciones psicofisiológicas; e identificar las necesidades buco-sanitarias propias de cada alumno para que, en colaboración con sus familias, sean atendidas. Entre las actividades destacan ponencias para formar a profesores y reuniones con padres para ayudarles en el cuidado buco-dental de sus hijos. Para preparar la visita al estomatólogo, se realizan juegos de ficción con pictogramas y situaciones similares a las que se encontrarían. La propia visita se graba para luego trabajar en el aula. La evaluación es continua y se basa en la adquisición de habilidades sociales y de comportamientos adaptativos. Cabe destacar que los niños autistas, con los apoyos necesarios, pueden aceptar la atención sanitaria en la red normalizada..Madrid (Comunidad Autónoma). Consejería de SanidadMadridNo disponibleES

La música como lenguaje en la educación del niño autista

Utiliza las posibilidades del lenguaje musical para desarrollar distintas capacidades del alumnado autista. Los objetivos son mejorar la afectividad, la personalidad, la conducta y la comunicación a través de la música; trabajar con el ritmo, la melodía, la armonía y los instrumentos; desarrollar las capacidades perceptivo-motrices que le permitan un conocimiento de las organizaciones espaciales, temporales y corporales; elaborar pautas de conducta idóneas que faciliten la interacción y adaptación interpersonal y social; y reforzar la autoestima y personalidad mediante la autorealización. Se utiliza cinco métodos musicales: Bon Depart, Carl Orff, Chevais, Arschero y Dactilorritmia. Se evalúa las capacidades, destrezas y habilidades desarrolladas por los aprendizajes por medio de una ficha inicial y registros de observación.Madrid (Comunidad Autónoma). Consejería de Educación y CulturaMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES