Peste porcine africaine Isolement et identification en France métropolitaine. Données épidémiologiques, cliniques, anatomopathologiques et de laboratoire

Gayot Georges, Carnero R., Costes Colette, Plateau F., Delclos G., Cazaubon P. Peste porcine africaine. In: Bulletin de l'Académie Vétérinaire de France tome 127 n°2, 1974. pp. 91-97

Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo

BACKGROUND: From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy. The aim of the present study was to determine some of the signaling pathways mediating angiotensin II (Ang II)-induced protein synthesis in vivo in large and small arteries. METHODS: Newly synthesized proteins were labeled during 4 hours with tritiated leucine in conscious control animals, or animals infused for 24 hours with angiotensin II (400 ng/kg/min). Hemodynamic parameters were measure simultaneously. Pharmacological agents affecting signaling cascades were injected 5 hours before the end of Ang II infusion. RESULTS: Angiotensin II nearly doubled the protein synthesis rate in the aorta and small mesenteric arteries, without affecting arterial pressure. The AT(1 )receptor antagonist Irbesartan antagonized the actions of Ang II. The Ang II-induced protein synthesis was associated with increased extracellular signal-regulated kinases (ERK)1/2 phosphorylation in aortic, but not in mesenteric vessels. Systemic administration of PD98059, an inhibitor of the ERK-1/2 pathway, produced a significant reduction of protein synthesis rate in the aorta, and only a modest decrease in mesenteric arteries. Rapamycin, which influences protein synthesis by alternative signaling, had a significant effect in both vessel types. Rapamycin and PD98059 did not alter basal protein synthesis and had minimal effects on arterial pressure. CONCLUSION: ERK1/2 and rapamycin-sensitive pathways are involved in pressure-independent angiotensin II-induced vascular protein synthesis in vivo. However, their relative contribution may vary depending on the nature of the artery under investigation

8p22 MTUS1 Gene Product ATIP3 Is a Novel Anti-Mitotic Protein Underexpressed in Invasive Breast Carcinoma of Poor Prognosis

BACKGROUND: Breast cancer is a heterogeneous disease that is not totally eradicated by current therapies. The classification of breast tumors into distinct molecular subtypes by gene profiling and immunodetection of surrogate markers has proven useful for tumor prognosis and prediction of effective targeted treatments. The challenge now is to identify molecular biomarkers that may be of functional relevance for personalized therapy of breast tumors with poor outcome that do not respond to available treatments. The Mitochondrial Tumor Suppressor (MTUS1) gene is an interesting candidate whose expression is reduced in colon, pancreas, ovary and oral cancers. The present study investigates the expression and functional effects of MTUS1 gene products in breast cancer. METHODS AND FINDINGS: By means of gene array analysis, real-time RT-PCR and immunohistochemistry, we show here that MTUS1/ATIP3 is significantly down-regulated in a series of 151 infiltrating breast cancer carcinomas as compared to normal breast tissue. Low levels of ATIP3 correlate with high grade of the tumor and the occurrence of distant metastasis. ATIP3 levels are also significantly reduced in triple negative (ER- PR- HER2-) breast carcinomas, a subgroup of highly proliferative tumors with poor outcome and no available targeted therapy. Functional studies indicate that silencing ATIP3 expression by siRNA increases breast cancer cell proliferation. Conversely, restoring endogenous levels of ATIP3 expression leads to reduced cancer cell proliferation, clonogenicity, anchorage-independent growth, and reduces the incidence and size of xenografts grown in vivo. We provide evidence that ATIP3 associates with the microtubule cytoskeleton and localizes at the centrosomes, mitotic spindle and intercellular bridge during cell division. Accordingly, live cell imaging indicates that ATIP3 expression alters the progression of cell division by promoting prolonged metaphase, thereby leading to a reduced number of cells ungergoing active mitosis. CONCLUSIONS: Our results identify for the first time ATIP3 as a novel microtubule-associated protein whose expression is significantly reduced in highly proliferative breast carcinomas of poor clinical outcome. ATIP3 re-expression limits tumor cell proliferation in vitro and in vivo, suggesting that this protein may represent a novel useful biomarker and an interesting candidate for future targeted therapies of aggressive breast cancer

The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes

VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad

Acta de congresoLa conmemoración de los cien años de la Reforma Universitaria de 1918 se presentó como una ocasión propicia para debatir el rol de la historia, la teoría y la crítica en la formación y en la práctica profesional de diseñadores, arquitectos y urbanistas. En ese marco el VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad constituyó un espacio de intercambio y reflexión cuya realización ha sido posible gracias a la colaboración entre Facultades de Arquitectura, Urbanismo y Diseño de la Universidad Nacional y la Facultad de Arquitectura de la Universidad Católica de Córdoba, contando además con la activa participación de mayoría de las Facultades, Centros e Institutos de Historia de la Arquitectura del país y la región. Orientado en su convocatoria tanto a docentes como a estudiantes de Arquitectura y Diseño Industrial de todos los niveles de la FAUD-UNC promovió el debate de ideas a partir de experiencias concretas en instancias tales como mesas temáticas de carácter interdisciplinario, que adoptaron la modalidad de presentación de ponencias, entre otras actividades. En el ámbito de VIII Encuentro, desarrollado en la sede Ciudad Universitaria de Córdoba, se desplegaron numerosas posiciones sobre la enseñanza, la investigación y la formación en historia, teoría y crítica del diseño, la arquitectura y la ciudad; sumándose el aporte realizado a través de sus respectivas conferencias de Ana Clarisa Agüero, Bibiana Cicutti, Fernando Aliata y Alberto Petrina. El conjunto de ponencias que se publican en este Repositorio de la UNC son el resultado de dos intensas jornadas de exposiciones, cuyos contenidos han posibilitado actualizar viejos dilemas y promover nuevos debates. El evento recibió el apoyo de las autoridades de la FAUD-UNC, en especial de la Secretaría de Investigación y de la Biblioteca de nuestra casa, como así también de la Facultad de Arquitectura de la UCC; va para todos ellos un especial agradecimiento

Fungal parasitism of the diatom Asterionella formosa Hassall (Bacillariophyceae) by Chytridiomycota

Many freshwater algae are parasitized by aquatic fungi belonging to the Chytridiales Order. The top-down effects of parasitism result in individual losses within algal populations. We present data on the parasitism of the diatom Asterionella formosa Hassall by chytrids, occurring in response to hydrodynamic disturbances and the architecture of the algal host on the landscape scale. Among a series of nine reservoirs, the observed pattern of parasitism depends on the levels of hydrodynamic disturbance: the rate of parasitism is higher at intermediate disturbance levels. A. formosa cells are not randomly parasitized. Whatever the disturbance levels, fungi were found to mostly parasitize cell clusters forming non-stellate colonies

The epizooty of foot and mouth disease in «Pyrénées- Atlantiques» (January 1981)

L’épizootie de fièvre aphteuse, qui a sévi dans le département des Pyrénées-Atlantiques au mois de janvier 1981, n’a diffusé que dans quatre exploitations porcines. Les mesures de prophylaxie médicale et sanitaire, mises en œuvre dès l’apparition du premier foyer, ont permis de juguler très rapidement la maladie. L’origine de l’affection, due à un virus de type C, est très vraisemblablement à rechercher de l’autre côté de la frontière franco-espagnole.The epizooty of foot and mouth disease which appeared in the Pyrénées- Atlantiques during the month of january 1981, spread in only four pig holdings. The medical and sanitary measures which have been edicted right after the first outbreak involved the quick disparition of the disease. The origin of the affection due to type C virus is probably located outside of the franco-spanish border

Architecture et gestion dissymetrique d'un bus numerique serie au standard hdlc

Le problème de l'utilisation, dès leur mise en production des technologies nouvelles dans les architectures informatiques réparties se pose aujourd'hui aux concepteurs de systèmes d'acquisition, de traitement du signal et d'extraction : a) Techniquement : seule une méthodologie rigoureuse et une analyse fonctionnelle précise peuvent aboutir à une définition d'architecture suffisamment modulaire pour permettre les améliorations rendues possibles à chaque nouvel apport technologique. b) Economiquement : une réduction substancielle des coûts de réalisation et d'intégration des systèmes peut alors être obtenue en standardisant les liaisons et les interfaces de connexion. Une telle démarche a été suivie pour la définition du bus ILC, liaison multipoint de type dissymétrique destinée en particulier à résoudre les problèmes d'acquisition numérique et de transmission du signal vidéo. Ce bus présente également l'avantage d'utiliser le protocole de contrôle par trames de bits HDLC, conforme au standard international ISO des télécommunications. L'exposé présenté se propose de décrire : a) les concepts qui ont présidé à la définition fonctionnelle de l'architecture et des interfaces standards correspondants, b) L'architecture interne du coupleur standard défini, c) Les performances attendues, d) L'intérêt de la modularité de la réalisation en cours, qui permettra son amélioration ultérieure et son évolution grâce aux technologies futures (fibres optiques, composants CCD, SAW), l'objectif final restant l'élaboration d'une architecture multipoints véritablement symétrique