1,816 research outputs found
Radiative transfer effects on Doppler measurements as sources of surface effects in sunspot seismology
We show that the use of Doppler shifts of Zeeman sensitive spectral lines to
observe wavesn in sunspots is subject to measurement specific phase shifts
arising from, (i) altered height range of spectral line formation and the
propagating character of p mode waves in penumbrae, and (ii) Zeeman broadening
and splitting. We also show that these phase shifts depend on wave frequencies,
strengths and line of sight inclination of magnetic field, and the polarization
state used for Doppler measurements. We discuss how these phase shifts could
contribute to local helioseismic measurements of 'surface effects' in sunspot
seismology.Comment: 12 pages, 4 figures, Accepted for publication in the Astrophysical
Journal Letter
Eating Disorders
Anorexia and bulimia are diseases known since ancient times, but in recent years their frequency has been continuously increasing in most industrialized countries. The etiology of these disorders can be traced back to the interaction between genetic predisposition, childhood experiences, and cultural pressures. As regards the course, a certain tendency to chronicity can be observed, and in extreme cases, they can cause death. According to the diagnostic classification of the DSM-5, eating disorders include anorexia nervosa, bulimia nervosa, binge eating disorder (which, compared to DSM-IV, becomes a diagnostic category in its own right), and other specified feeding and eating disorders (OSFED). Both anorexia and bulimia cause potentially serious medical complications. To maximize the chances of good outcomes a multidisciplinary intervention is necessary with staff including professionally heterogeneous figures: a psychiatrist, a psychologist, and a nutritionist. Therapeutic success for these patients is limited. Eating disorders require, among psychiatric disorders, the greatest possible collaboration between different professional figures with different specializations
The Stability of TSH, and Thyroid Hormones, in Patients Treated With Tablet, or Liquid Levo-Thyroxine
Approximately, 5% of the population is affected by hypothyroidism, mainly women and persons aged more than 60 years. After the diagnosis of hypothyroidism the usual therapy is tablet levothyroxine (L-T4), with a monitoring of the thyroid-stimulating hormone (TSH) level in primary hypothyroidism every 6-8 weeks and L-T4 is adjusted as necessary to reach an euthyroid state. Once TSH is stabilized in the normal range, it is recommended to conduct annual testing in the treated subjects to warrant suitable replacement. More recently advances regarding L-T4 treatment are the introduction of new oral formulations: the liquid solution, and soft gel capsule. The soft gel capsule permits a quick dissolution in the acid gastric pH. The liquid preparation does not require an acid gastric environment. Many pharmacokinetic studies demonstrated a more rapid absorption for the liquid L-T4, or capsule, than with tablet. Many studies have shown that the liquid, or capsule, formulations can overcome the interaction with foods, drugs or malabsorptive conditions, that are able to impair the tablet L-T4 absorption. Lately studies have suggested that liquid L-T4 can permit to maintain more efficiently normal TSH levels in hypothyroid patients in the long-term follow-up, than tablet L-T4, both in patients with malabsorptive states, and in those without malabsorption. Further large, prospective, longitudinal studies are needed to evaluate the stability of TSH, in hypothyroid patients treated with different L-T4 formulations
Searching for Planets in the Hyades II: Some Implications of Stellar Magnetic Activity
The Hyades constitute a homogeneous sample of stars ideal for investigating
the dependence of planet formation on the mass of the central star. Due to
their youth, Hyades members are much more chromospherically active than stars
traditionally surveyed for planets using high precision radial velocity (RV)
techniques. Therefore, we have conducted a detailed investigation of whether
magnetic activity of our Hyades target stars will interfere with our ability to
make precise RV searches for substellar companions. We measure chromospheric
activity (which we take as a proxy for magnetic activity) by computing the
equivalent of the R'HK activity index from the Ca II K line. is not
constant in the Hyades: we confirm that it decreases with increasing
temperature in the F stars, and also find it decreases for stars cooler than
mid-K. We examine correlations between simultaneously measured R'HK and RV
using both a classical statistical test and a Bayesian odds ratio test. We find
that there is a significant correlation between R'HK and the RV in only 5 of
the 82 stars in this sample. Thus, simple Rprime HK-RV correlations will
generally not be effective in correcting the measured RV values for the effects
of magnetic activity in the Hyades. We argue that this implies long timescale
activity variations (of order a few years; i.e., magnetic cycles or growth and
decay of plage regions) will not significantly hinder our search for planets in
the Hyades if the stars are closely monitored for chromospheric activity. The
trends in the RV scatter (sigma'_v) with , vsini, and P_rot for our stars
is generally consistent with those found in field stars in the Lick planet
search data, with the notable exception of a shallower dependence of sigma'_v
on for F stars.Comment: 15 pages, 7 figures, 3 tables; To appear in the July 2002 issue of
The Astronomical Journa
Cytokines as Targets of Novel Therapies for Gravesâ Ophthalmopathy
Graves' disease (GD) is an organ-specific autoimmune disorder of the thyroid, which is characterized by circulating TSH-receptor (TSH-R) stimulating antibodies (TSAb), leading to hyperthyroidism. Graves' ophthalmopathy (GO) is one of GD extra-thyroidal manifestations associated with the presence of TSAb, and insulin-like growth factor-1 receptor (IGF-1R) autoantibodies, that interact with orbital fibroblasts. Cytokines are elevated in autoimmune (i.e., IL-18, IL-6) and non-autoimmune hyperthyroidism (i.e., TNF-α, IL-8, IL-6), and this could be associated with the chronic effects of thyroid hormone increase. A prevalent Th1-immune response (not related to the hyperthyroidism per se, but to the autoimmune process) is reported in the immune-pathogenesis of GD and GO; Th1-chemokines (CXCL9, CXCL10, CXCL11) and the (C-X-C)R3 receptor are crucial in this process. In patients with active GO, corticosteroids, or intravenous immunoglobulins, decrease inflammation and orbital congestion, and are considered first-line therapies. The more deepened understanding of GO pathophysiology has led to different immune-modulant treatments. Cytokines, TSH-R, and IGF-1R (on the surface of B and T lymphocytes, and fibroblasts), and chemokines implicated in the autoimmune process, are possible targets of novel therapies. Drugs that target cytokines (etanercept, tocilizumab, infliximab, adalimumab) have been tested in GO, with encouraging results. The chimeric monoclonal antibody directed against CD20, RTX, reduces B lymphocytes, cytokines and the released autoantibodies. A multicenter, randomized, placebo-controlled, double-masked trial has investigated the human monoclonal blocking antibody directed against IGF-1R, teprotumumab, reporting its effectiveness in GO. In conclusion, large, controlled and randomized studies are needed to evaluate new possible targeted therapies for GO
The peculiar landscape of repetitive sequences in the olive (Olea europaea L.) genome
Analyzing genome structure in different species allows to gain an insight into the evolution of plant genome size. Olive (Olea europaea L.) has a medium-sized haploid genome of 1.4 Gb, whose structure is largely uncharacterized, despite the growing importance of this tree as oil crop. Next-generation sequencing technologies and different computational procedures have been used to study the composition of the olive genome and its repetitive fraction. A total of 2.03 and 2.3 genome equivalents of Illumina and 454 reads from genomic DNA, respectively, were assembled following different procedures, which produced more than 200,000 differently redundant contigs, with mean length higher than 1,000 nt. Mapping Illumina reads onto the assembled sequences was used to estimate their redundancy. The genome data set was subdivided into highly and medium redundant and nonredundant contigs. By combining identification and mapping of repeated sequences, it was established that tandem repeats represent a very large portion of the olive genome (âŒ31% of the whole genome), consisting of six main families of different length, two of which were first discovered in these experiments. The other large redundant class in the olive genome is represented by transposable elements (especially long terminal repeat-retrotransposons). On the whole, the results of our analyses show the peculiar landscape of the olive genome, related to the massive amplification of tandem repeats, more than that reported for any other sequenced plant genome
Seeing-Induced Errors in Solar Doppler Velocity Measurements
Imaging systems based on a narrow-band tunable filter are used to obtain
Doppler velocity maps of solar features. These velocity maps are created by
taking the difference between the blue- and red-wing intensity images of a
chosen spectral line. This method has the inherent assumption that these two
images are obtained under identical conditions. With the dynamical nature of
the solar features as well as the Earth's atmosphere, systematic errors can be
introduced in such measurements. In this paper, a quantitative estimate of the
errors introduced due to variable seeing conditions for ground-based
observations is simulated and compared with real observational data for
identifying their reliability. It is shown, under such conditions, that there
is a strong cross-talk from the total intensity to the velocity estimates.
These spurious velocities are larger in magnitude for the umbral regions
compared to the penumbra or quiet-sun regions surrounding the sunspots. The
variable seeing can induce spurious velocities up to about 1 km/s It is also
shown that adaptive optics, in general, helps in minimising this effect.Comment: 14 page
Nation and/or Homeland: Identity in 19th-Century Music and Literature between Central and Mediterranean Europe
The aim of this book is to focus on the development of national awareness elaborated around a series of different case studies, in which the terms nation, homeland and people have been applied. This Romantic lexicon identifies similar but various conceptions of the national idea in some countries dominated by Italian, German and Slavic cultures, and in some groups or minorities such as the Jews and the Vlachs in Central and Mediterranean Europe. In order to clarify the cultural framework, the authors explore the construction of identity through folk tunes, poetry inspired by popular culture, and opera in which the national myths or heroes appear. In the self-making tradition, the national traits are sustained by the process of embodiment of any regional utterance, and also by disregarding the \u201cother\u201d, in particular the minorities. The symbols of the nation, as an achievement of the power that flourishes from the sense of belonging, are defined \u201cper differentiam\u201d. Theoretical perspectives are shaped by the new approaches to this topic, taking into consideration the artistic issues as socio-historical events and subsequently evaluating them in their aesthetic quality
Efficacy of biofeedback rehabilitation based on visual evoked potentials analysis in patients with advanced age-related macular degeneration
Age-related macular degeneration (AMD) is a progressive and degenerative disorder of the macula. In advanced stages, it is characterized by the formation of areas of geographic atrophy or fibrous scars in the central macula, which determines irreversible loss of central vision. These patients can benefit from visual rehabilitation programmes with acoustic "biofeedback" mechanisms that can instruct the patient to move fixation from the central degenerated macular area to an adjacent healthy area, with a reorganization of the primary visual cortex. In this prospective, comparative, non-randomized study we evaluated the efficacy of visual rehabilitation with an innovative acoustic biofeedback training system based on visual evoked potentials (VEP) real-time examination (Retimax Vision Trainer, CSO, Florence), in a series of patients with advanced AMD compared to a control group. Patients undergoing training were subjected to ten consecutive visual training sessions of 10min each, performed twice a week. Patients in the control group did not receive any training. VEP biofeedback rehabilitation seems to improve visual acuity, reading performances, contrast sensitivity, retinal fixation and sensitivity and quality of life in AMD patients
Tracing the identity of Parmigiano Reggiano âProdotto di Montagna - Progetto Territorioâ cheese using NMR spectroscopy and multivariate data analysis
Background
Nuclear magnetic resonance (NMR) spectroscopy is one of the well-established tools for food metabolomic analysis, as it proved to be very effective in authenticity and quality control of dairy products, as well as to follow product evolution during processing and storage. The analytical assessment of the EU mountain denomination label, specifically for Parmigiano Reggiano "Prodotto di Montagna - Progetto Territorio" (Mountain-CQ) cheese, has received limited attention. Although it was established in 2012 the EU mountain denomination label has not been much studied from an analytical point of view. Nonetheless, tracing a specific profile for the mountain products is essential to support the value chain of this specialty.
Results
The aim of the study was to produce an identity profile for Parmigiano Reggiano âProdotto di Montagna - Progetto Territorioâ (Mountain-CQ) cheese, and to differentiate it from Parmigiano Reggiano PDO samples (conventional-PDO) using 1H NMR spectroscopy coupled with multivariate data analysis. Three different approaches were applied and compared. First, the spectra-as-such were analysed after proper preprocessing. For the other two approaches, Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) was used for signals resolution and features extraction, either individually on manually-defined spectral intervals or by reapplying MCR-ALS on the whole spectra with selectivity constraints using the reconstructed âpure profilesâ as initial estimates and targets. All approaches provided comparable information regarding the samplesâ distribution, as in all three cases the separation between the two product categories conventional-PDO and Mountain-CQ could be highlighted. Moreover, a novel MATLAB toolbox for features extraction via MCR-ALS was developed and used in synergy with the Chenomx library, allowing for a putative identification of the selected features.
Significance
A first identity profile for Parmigiano Reggiano âProdotto di Montagna - Progetto Territorioâ obtained by interpreting the metabolites signals in NMR spectroscopy was obtained. Our workflow and toolbox for generating the features dataset allows a more straightforward interpretation of the results, to overcome the limitations due to dimensionality and to peaks overlapping, but also to include the signals assignment and matching since the early stages of the data processing and analysis
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