Publishing an E-journal on a shoe string: Is it a sustainaible project?.

The aim of this article is to report on an experiment in publishing an open access journal and learn from it about the larger field of open access publishing. The experiment is the launch of the European Journal of Comparative Economics (EJCE), an on-line refereed and open access journal, founded in 2004 by the European Association for Comparative Economic Studies and LIUC University in Italy. They embarked upon this project in part to respond to the rising concentration in the market for scientific publishing and the resulting use of market power to raise subscription prices and restrict access to scientific output. We had hoped that open access journals could provide some countervailing power and increase competition in the field. Our experience running a poorly endowed journal has shown that entry to the field may be easy, yet that making it a sustainable enterprise is not straightforward.Open-access publishing, online journals, scientific publication

From Man as Predator to Man as Giver. Reflections on the Gift and the Self-Giving in Psychology

Considering the values and the cultural model today prevailing, all centred on narcissistic individualism and extreme competition, Chiara Lubich’s thought on gift and self – giving is likely to look ingenuous and absurd. However, this thought is confirmed in the secular culture of today and in particular in the psychological studies

Il dono nel tempo della crisi. Per una psicologia del riconoscimento

Il dono nel tempo della crisi. Per una psicologia del riconosciment

Le implicazioni psicologiche del dono e del donarsi

Le implicazioni psicologiche del dono e del donars

Focus on children murdered by parents in Italy: A sad reality

With a documented history of over a century, it is noted that child murders, perpetrated by their own parents, are an interesting and dramatic phenomenon in the Italian territory. There are three forms of child homicides: neonaticide, infanticide and filicide. Thanks to several legal reports and studies, it is possible to draw the profile of the typical murderer: usually a young, Northern Italian woman, unemployed, in a conflicting relationship and suffering from psychiatric disorders. In most cases, the crime takes place at home. No particular method for committing the murder is preferred, but the death of the child can be due to different causes. Precautionary measures should be taken: parents should never be left alone facing health or psychiat-ric problems, families should be helped and supported during difficult times, women should be well-in-formed and aware of their rights

Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trialResearch in context

Summary: Background: Major depressive disorder (MDD) is prevalent and disabling among older adults. Standing on its tolerability profile, vortioxetine might be a promising alternative to selective serotonin reuptake inhibitors (SSRIs) in such a vulnerable population. Methods: We conducted a randomised, assessor- and statistician-blinded, superiority trial including older adults with MDD. The study was conducted between 02/02/2019 and 02/22/2023 in 11 Italian Psychiatric Services. Participants were randomised to vortioxetine or one of the SSRIs, selected according to common practice. Treatment discontinuation due to adverse events after six months was the primary outcome, for which we aimed to detect a 12% difference in favour of vortioxetine. The study was registered in the online repository clinicaltrials.gov (NCT03779789). Findings: The intention-to-treat population included 179 individuals randomised to vortioxetine and 178 to SSRIs. Mean age was 73.7 years (standard deviation 6.1), and 264 participants (69%) were female. Of those on vortioxetine, 78 (44%) discontinued the treatment due to adverse events at six months, compared to 59 (33%) of those on SSRIs (odds ratio 1.56; 95% confidence interval 1.01–2.39). Adjusted and per-protocol analyses confirmed point estimates in favour of SSRIs, but without a significant difference. With the exception of the unadjusted survival analysis showing SSRIs to outperform vortioxetine, secondary outcomes provided results consistent with a lack of substantial safety and tolerability differences between the two arms. Overall, no significant differences emerged in terms of response rates, depressive symptoms and quality of life, while SSRIs outperformed vortioxetine in terms of cognitive performance. Interpretation: As opposed to what was previously hypothesised, vortioxetine did not show a better tolerability profile compared to SSRIs in older adults with MDD in this study. Additionally, hypothetical advantages of vortioxetine on depression-related cognitive symptoms might be questioned. The study's statistical power and highly pragmatic design allow for generalisability to real-world practice. Funding: The study was funded by the Italian Medicines Agency within the “2016 Call for Independent Drug Research”