Mapping the morbidity and mortality of Chagas disease in an endemic area in Brazil

Chagas disease is among the 21 neglected diseases according to the World Health Organization. This study aimed to investigate the morbidity and mortality distribution of Chagas disease for identifying areas with greater prevalences and deaths of the disease in Northeast Brazil. A population-based ecological study was performed from 2016 to 2018 using data on acute Chagas disease patients from the Disease Notification Information System, chronic cases from the Chagas Disease and the referral Heart Failure Outpatient Clinic in Pernambuco, and Chagas disease-related mortality from the Mortality Information System. The unit of analysis were Pernambuco State mesoregions. The indicators were spatialized into thematic maps on the occurrence and mortality of the disease per 100,000 inhabitants. No cases of acute disease were reported in the period analyzed. Data on 801 chronic Chagas disease patients were analyzed. The population showed an average age of 62 years, with female predominance. The most prevalent comorbidity was systemic arterial hypertension and cardiologic involvement without ventricular dysfunction. The average chronic disease occurrence rate was 3.2/ 100,000 people/ year. As for deaths in the mortality system; in total, 350 deaths were recorded, showing male predominance, age ≥ 60 years, and chronic disease with cardiac involvement as the main mortality cause. The annual average mortality proportion was 1.6/100,000 people. The chronic case distribution showed spatial heterogeneity, with the highest rates of chronic disease and deaths observed in two mesoregions, with the main cause of death being heart-related. This highlights the need for more specialized services in areas with higher burden of the disease to avoid delay in the patients’ care

Evaluation of CD4+CD25+ T lymphocyte response time kinetics in patients with chronic Chagas disease after in vitro stimulation with recombinant Trypanosoma cruzi antigens

Submitted by Kamylla Nascimento ([email protected]) on 2017-12-13T13:12:46Z No. of bitstreams: 1 art. Evaluation of CD4 - braz.pdf: 861951 bytes, checksum: 0541416cee2f58eceb55612e79c1c08b (MD5)Approved for entry into archive by Kamylla Nascimento ([email protected]) on 2017-12-13T13:23:11Z (GMT) No. of bitstreams: 1 art. Evaluation of CD4 - braz.pdf: 861951 bytes, checksum: 0541416cee2f58eceb55612e79c1c08b (MD5)Made available in DSpace on 2017-12-13T13:23:11Z (GMT). No. of bitstreams: 1 art. Evaluation of CD4 - braz.pdf: 861951 bytes, checksum: 0541416cee2f58eceb55612e79c1c08b (MD5) Previous issue date: 2013Esta pesquisa recebeu apoio financeiro pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Edital Universal n. ° 478572 / 2009-3) e Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes). YM Gomes é um colega do CNPq (número 306427 / 2006-0). VMB Lorena é um colega pós-docente do CNPq. SCM Braz e AS Melo foram candidatos ao Mestrado em Saúde Pública (CPqAM-FIOCRUZ) e foram CNPq (número 131310 / 2009-8) e bolsistas Capes, respectivamente.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Fundação Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Universidade de Pernambuco. Pronto-socorro Cardiológico de Pernambuco. Recife, PE, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Fundação Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brazil.CD4+CD25+ T lymphocytes have been implicated in the regulation of host inflammatory response against Trypanosoma cruzi, and may be involved in the clinical course of the disease

Expression of co-stimulatory molecules CD80 and CD86 is altered in CD14 + HLA-DR + monocytes from patients with Chagas disease following induction by Trypanosoma cruzi recombinant antigens

Abstract INTRODUCTION The relationships between monocytes and lymphocytes through MHC class II molecules and costimulatory, are of utmost importance for the production of an efficient immune response. In this work, we assessed the expression of surface molecules CD80 and CD86 on CD14+HLA-DR+ monocytes from patients with Chagas disease. METHODS: The study population consisted of 31 patients with chronic clinical forms of Chagas disease. Patient blood samples were cultured in the presence of recombinant cytoplasmic repetitive antigen (CRA) and flagellar repetitive antigen (FRA). RESULTS: We found considerable differences in the expression profile of surface molecules involved in antigen presentation. CONCLUSIONS: CRA and FRA may contribute to host immune response evasion by Trypanozoma cruzi