Family History and Breast Cancer Hormone Receptor Status in a Spanish Cohort

Breast cancer is a heterogenous disease that impacts racial/ethnic groups differently. Differences in genetic composition, lifestyles, reproductive factors, or environmental exposures may contribute to the differential presentation of breast cancer among Hispanic women.A population-based study was conducted in the city of Santiago de Compostela, Spain. A total of 645 women diagnosed with operable invasive breast cancer between 1992 and 2005 participated in the study. Data on demographics, breast cancer risk factors, and clinico-pathological characteristics of the tumors were collected. Hormone receptor negative tumors were compared with hormone receptor postive tumors on their clinico-pathological characteristics as well as risk factor profiles.Among the 645 breast cancer patients, 78% were estrogen receptor-positive (ER+) or progesterone receptor-positive (PR+), and 22% were ER−&PR−. Women with a family history of breast cancer were more likely to have ER−&PR− tumors than women without a family history (Odds ratio, 1.43; 95% confidence interval, 0.91–2.26). This association was limited to cancers diagnosed before age 50 (Odds ratio, 2.79; 95% confidence interval, 1.34–5.81).An increased proportion of ER−&PR− breast cancer was observed among younger Spanish women with a family history of the disease

Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations

Thyroid cancer is the most heritable cancer of all those not displaying typical Mendelian inheritance. However, most of the genetic factors that would explain the high heritability remain unknown. Our aim was to identify additional common genetic variants associated with susceptibility to this disease. In order to do so, we performed a genome-wide association study in a series of 398 cases and 502 controls from Spain, followed by a replication in four well-defined Southern European case-control collections contributing a total of 1,422 cases and 1,908 controls. The association between the variation at the 9q22 locus near FOXE1 and thyroid cancer risk was consistent across all series, with several SNPs identified (rs7028661: OR = 1.64, p = 1.0 x 10(-22) , rs7037324: OR = 1.54, p = 1.2 x 10(-17) ). Moreover, the rare alleles of three SNPs (rs2997312, rs10788123 and rs1254167) at 10q26.12 showed suggestive evidence of association with higher risk of the disease (OR = 1.35, p = 1.2 x 10(-04) , OR = 1.26, p = 5.2 x 10(-04) and OR = 1.38, p = 5.9 x 10(-05) , respectively). Finally, the rare allele of rs4075570 at 6q14.1 conferred protection in the series studied (OR = 0.82, p = 2.0 x 10(-04) ). This study suggests that heterogeneity in genetic susceptibility between populations is a key feature to take into account when exploring genetic risk factors related to this disease

Clinicopathological, Karyometric, and Immunohistochemical Characteristics of Breast Cancer Cases and by ER and PR status.

1<p>Ps for categorical variables were estimated from χ² tests. P for the comparison of median ages was esimated from Wilcoxon Rank-Sum test and Ps for other continuous variables were estimated from t-tests.</p>2<p>Histology, lymph node metastasis, grade, MIB1, P53 expression and DNA ploidy index, were unknown for 2, 7, 106, 121, 230 and 1 cases, respectively.</p>3<p>Data on nuclear are, perimeter and DNA shape were available for only 353 cases.</p>4<p>Mean ±standard deviation.</p

Clinicopathological, karyometric, and immunohistochemical characteristics of breast cancer by family history.

1<p>Ps for categorical variables were estimated from χ² tests. P for the comparison of median ages was esimated from Wilcoxon Rank-Sum test and Ps for other continuous variables were estimated from t-tests.</p>2<p>Histology, lymph node metastasis, grade, MIB1, P53 expression and DNA ploidy index were unknown for 11, 48, 2, 7, 106, 121, 230 and 1 cases, respectively.</p>3<p>Data on nuclear are, perimeter and DNA shape were available for only 353 cases.</p>4<p>Mean ±standard deviation.</p

Association between select breast cancer risk factors and hormone receptor status.

1<p>Results were estimated from case-only logistic regressions with adjustment for age at diagnosis.</p