Motivational modulation of on-line attention control processes

This thesis brings together two broad subdisciplines of psychology--cognition and motivation--in order to explore how motivational processes interact on-line with cognitive mechanisms in directing human behaviour and performance. A series of five experiments were conducted in which the Rogers and Monsell (1995) task switching paradigm was combined with motivational manipulations involving earned point incentives (Derryberry, 1993) to investigate the effects of prior and current motivation on task execution, attention switching, and inhibition. Using a left/right button press, participants alternated every second trial between vowel/consonant (letter task) and even/odd (digit task) judgments in response to target-foil stimulus pairs (e.g., A3, G#, ?6) presented on a computer monitor. Participants responded to the letter or digit target while inhibiting the competing (letter or digit) or neutral (symbol) foil. Task motivation was manipulated by assigning participants equal or differential incentives for letter and digit task performance during an initial training phase or during the switch task itself. Motivational incentives were found to have a large and selective influence on attention switching, evidenced by faster switching to the high-valued than low-valued task, but had no effect on either simple task execution processes or the inhibition of task-set cuing by a competing foil. In addition, prior motivational experience with differential task incentives during training had a greater and more reliable impact on attention switching than did current differential incentives applied during the switch task itself. These results reveal that motivation does not simply have a global facilitating influence on performance, but rather operates through highly specific mechanisms to bias goal-directed behaviour. Results are interpreted in terms of the apparent differential sensitivity to motivational input exhibited by attention control mechanisms versus automatic, stimulus-triggered processes. A further distinction is made between implicit motivational modulation of executive control mechanisms versus the engagement of an optional, incentive-based performance strategy. Also discussed are speculations regarding underlying neural mechanisms mediating these motivational influences on attention and the potential implications of these results for skill development and performance

Reference-free removal of EEG-fMRI ballistocardiogram artifacts with harmonic regression

Combining electroencephalogram (EEG) recording and functional magnetic resonance imaging (fMRI) offers the potential for imaging brain activity with high spatial and temporal resolution. This potential remains limited by the significant ballistocardiogram (BCG) artifacts induced in the EEG by cardiac pulsation-related head movement within the magnetic field. We model the BCG artifact using a harmonic basis, pose the artifact removal problem as a local harmonic regression analysis, and develop an efficient maximum likelihood algorithm to estimate and remove BCG artifacts. Our analysis paradigm accounts for time-frequency overlap between the BCG artifacts and neurophysiologic EEG signals, and tracks the spatiotemporal variations in both the artifact and the signal. We evaluate performance on: simulated oscillatory and evoked responses constructed with realistic artifacts; actual anesthesia-induced oscillatory recordings; and actual visual evoked potential recordings. In each case, the local harmonic regression analysis effectively removes the BCG artifacts, and recovers the neurophysiologic EEG signals. We further show that our algorithm outperforms commonly used reference-based and component analysis techniques, particularly in low SNR conditions, the presence of significant time-frequency overlap between the artifact and the signal, and/or large spatiotemporal variations in the BCG. Because our algorithm does not require reference signals and has low computational complexity, it offers a practical tool for removing BCG artifacts from EEG data recorded in combination with fMRI.National Institutes of Health (U.S.) (Award DP1-OD003646)National Institutes of Health (U.S.) (Award TR01-GM104948)National Institutes of Health (U.S.) (Grant R44NS071988)National Institute of Neurological Diseases and Stroke (U.S.) (Grant Grant R44NS071988

Pharmacokinetics and Safety of Prolonged Paracetamol Treatment in Neonates: An Interventional Cohort Study

Aims To investigate the pharmacokinetics and safety of prolonged paracetamol use (\u3e72 h) for neonatal pain. Methods Neonates were included if they received paracetamol orally or intravenously for pain treatment. A total of 126 samples were collected. Alanine aminotransferase and bilirubin were measured as surrogate liver safety markers. Paracetamol and metabolites were measured in plasma. Pharmacokinetic parameters for the parent compound were estimated with a nonlinear mixed-effects model. Results Forty-eight neonates were enrolled (38 received paracetamol for \u3e72 h). Median gestational age was 38 weeks (range 25–42), and bodyweight at inclusion was 2954 g (range 713–4750). Neonates received 16 doses (range 4–55) over 4.1 days (range 1–13.8). The median (range) dose was 10.1 mg/kg (2.9–20.3). The median oxidative metabolite concentration was 14.6 μmol/L (range 0.12–113.5) and measurable \u3e30 h after dose. There was no significant difference (P \u3e .05) between alanine aminotransferase and bilirubin measures at \u3c72 h or \u3e72 h of paracetamol treatment or the start and end of the study. Volume of distribution and paracetamol clearance for a 2.81-kg neonate were 2.99 L (% residual standard error = 8, 95% confidence interval 2.44–3.55) and 0.497 L/h (% residual standard error = 7, 95% confidence interval 0.425–0.570), respectively. Median steady-state concentration from the parent model was 50.3 μmol/L (range 30.6–92.5), and the half-life was 3.55 h (range 2.41–5.65). Conclusion Our study did not provide evidence of paracetamol-induced liver injury nor changes in metabolism in prolonged paracetamol administration in neonates

Sesso nel Rinascimento

Questo volume propone un discorso critico sulla sessualità e sulla cultura visiva dell’Italia rinascimentale. I saggi raccolti tentano di fare luce su una serie di zone d’ombra, dando spazio a tutte quelle pratiche o preferenze considerate in genere come alternative o anomalie, e a un’ampia varietà di scenari “scandalosi”. Particolare attenzione è stata riservata all’aspetto materiale della cultura sessuale, dalle modalità di rappresentazione erotica del corpo agli oggetti e agli strumenti associati all’attività sessuale. Ne emerge un quadro completamente nuovo della sessualità rinascimentale, che spazza via secoli di manipolazioni ed equivoci socio-culturali, svelando scenari finora trascurati o volutamente nascosti. Diciassette saggi provocatori, con incursioni nel campo dell’arte, della letteratura, della storia, e persino della filosofia, organizzati intorno a quattro assi fondamentali: la pratica, la performance, la perversione e la punizione. Questo volume rivela un panorama molto più complesso e una visione del sesso e della sessualità rinascimentali carica di nuove sfumature

Social partners going digital: using digital tools and adapting social dialogue processes

Aquesta publicació s'elabora a partir de les contribucions de cadascú dels membres nacionals que integren la Network of Eufound Correspondent. Pel cas d'Espanya la contribució ha estat realitzada per l'Alejandro GodinoDigital transformation is changing the world of work. This report looks at how social partners - the actors involved in the regulation of employment relationships - are increasingly adopting technological solutions to improve the services that they provide to their members and facilitate collective bargaining processes. Technological tools offer social partners the opportunity to enhance consultation, engage with their members through digitised processes, improve services and increase networking activities, as well as addressing the issue of membership decline. The findings of this report show that the extent to which the social partners use digital technologies varies greatly across the EU Member States, Norway and the United Kingdom. Provisions in collective agreements on several aspects of digitalisation have been identified in about half of the countries. Through these provisions, social partners encourage their members to boost training on digital skills, ensure fair and safe working conditions and take account of data protection and employee monitoring practices. The European social partners' autonomous framework agreement on digitalisation has provided inspiration to national-level organisations, and follow-up actions in this regard have the potential to greatly benefit their members

Social partners going digital: using digital tools and adapting social dialogue processes

La xarxa de corresponsals d'Eurofound ha contribuït a aquest informe i en concret l'Alejandro Godino com així s'expressa a l'Annex 3: Network of Eurofound CorrespondentsDigital transformation is changing the world of work. This report looks at how social partners - the actors involved in the regulation of employment relationships - are increasingly adopting technological solutions to improve the services that they provide to their members and facilitate collective bargaining processes. Technological tools offer social partners the opportunity to enhance consultation, engage with their members through digitised processes, improve services and increase networking activities, as well as addressing the issue of membership decline. The findings of this report show that the extent to which the social partners use digital technologies varies greatly across the EU Member States, Norway and the United Kingdom. Provisions in collective agreements on several aspects of digitalisation have been identified in about half of the countries. Through these provisions, social partners encourage their members to boost training on digital skills, ensure fair and safe working conditions and take account of data protection and employee monitoring practices. The European social partners' autonomous framework agreement on digitalisation has provided inspiration to national-level organisations, and follow-up actions in this regard have the potential to greatly benefit their members

The P2Y1 receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice

Pancreatic β cells express several P2 receptors including P2Y1 and the modulation of insulin secretion by extracellular nucleotides has suggested that these receptors may contribute to the regulation of glucose homeostasis. To determine whether the P2Y1 receptor is involved in this process, we performed studies in P2Y1 mice. In baseline conditions, P2Y1-mice exhibited a 15% increase in glycemia and a 40% increase in insulinemia, associated with a 10% increase in body weight, pointing to a role of the P2Y1 receptor in the control of glucose metabolism. Dynamic experiments further showed that P2Y1-mice exhibited a tendency to glucose intolerance. These features were associated with a decrease in the plasma levels of free fatty acid and triglycerides. When fed a lipids and sucrose enriched diet for 15 weeks, the two genotypes no longer displayed any significant differences. To determine whether the P2Y1 receptor was directly involved in the control of insulin secretion, experiments were carried out in isolated Langerhans islets. In the presence of high concentrations of glucose, insulin secretion was significantly greater in islets from P2Y1-mice. Altogether, these results show that the P2Y1 receptor plays a physiological role in the maintenance of glucose homeostasis at least in part by regulating insulin secretion

Enhancing volunteer engagement to achieve desirable outcomes: what can non-profit employers do?

Abstract Engagement is a positive psychological state that is linked with a range of beneficial individual and organizational outcomes. However, the factors associated with volunteer engagement have rarely been examined. Data from 1064 volunteers of a wildlife charity in the United Kingdom revealed that both task- and emotion-oriented organizational support were positively related to volunteer engagement, and volunteer engagement was positively related to volunteer happiness and perceived social worth and negatively related to intent to leave the voluntary organization. Consistent with theory, engagement acted as a mediator between these factors. The implications for future research and the relevance of the findings for voluntary organizations are discussed