Microbiota of the Tongue and Systemic Connections: The Examination of the Tongue as an Integrated Approach in Oral Medicine

The tongue is able to quickly reflect the state of health or disease of the human body. Tongue inspection is an important diagnostic approach. It is a unique method that allows to explore the pathogenesis of diseases based on the guiding principles of the holistic concept that involves the observation of changes in the lining of the tongue in order to understand the physiological functions and pathological changes of the body. It is a potential method of screening and early detection of cancer. However, the subjective inspection of the tongue has a low reliability index, and therefore computerized systems of acquisition of diagnostic bioinformation have been developed to analyze the lining of the tongue. Next-generation sequencing technology is used to determine the V2–V4 hypervariable regions of 16S rRNA to study the microbiota. A lot of neoplasms are identified only at an advanced phase, while in the early stages, many subjects remain in an asymptomatic form. On the contrary, the early diagnosis is able to increase the prognosis of cancer and improve the survival rates of subjects. Evidently, it is necessary to develop new strategies in oral medicine for the early diagnosis of diseases, and the diagnosis of the tongue as a minimally invasive method is certainly one of them

Manuale d'uso del logo INAF - Istituto Nazionale di Astrofisica

Nel presente Manuale d'uso sono dettagliate alcune indicazioni utili per l'utilizzo del logo dell'INAF, Istituto Nazionale di Astrofisica, e le modalità per la richiesta di concessione in utilizzo del logo stesso da parte di terzi. Dopo diciassette anni dal suo progetto, il logo ha di recente avuto un restyling curato da Stefano Asili, già ideatore del logo originario. Gli interventi di restyling, pur fatti con mano leggera, sono sostanziali: dalla scelta del carattere tipografico alle proporzioni, agli allineamenti. Segnaliamo infatti l’introduzione di un nuovo carattere tipografico: l’Eurostile di Aldo Novarese. Progettato nel 1962 - su base del precedente Microgramma del 1952, di Alessandro Butti e dello stesso Novarese - l’Eurostile è diventato lo standard dell’immaginario spaziale. Da Hal 9000 di Kubrick a un'innumerevole serie di film, questo carattere perennemente moderno è sembrato irrinunciabile per un ente scientifico che scandaglia ogni giorno gli oggetti più lontani dell’universo. Sono riportati anche alcuni elementi esemplificativi di immagine coordinata e alcune pratiche di utilizzo errato, utili a orientare senza errori i designer che avranno a che fare con la nuova identità. Il risultato è un marchio che non cambia di senso ma acquista in forza, come forte è la decisione di declinare il logo esteso solo in italiano

Lower-order compensation chain threshold-reduction technique for multi-stage voltage multipliers

This paper presents a novel threshold-compensation technique for multi-stage voltage multipliers employed in low power applications such as passive and autonomous wireless sensing nodes (WSNs) powered by energy harvesters. The proposed threshold-reduction technique enables a topological design methodology which, through an optimum control of the trade-off among transistor conductivity and leakage losses, is aimed at maximizing the voltage conversion efficiency (VCE) for a given ac input signal and physical chip area occupation. The conducted simulations positively assert the validity of the proposed design methodology, emphasizing the exploitable design space yielded by the transistor connection scheme in the voltage multiplier chain. An experimental validation and comparison of threshold-compensation techniques was performed, adopting 2N5247 N-channel junction field effect transistors (JFETs) for the realization of the voltage multiplier prototypes. The attained measurements clearly support the effectiveness of the proposed threshold-reduction approach, which can significantly reduce the chip area occupation for a given target output performance and ac input signal

Joint exploitation of space-borne and ground-based multitemporal InSAR measurements for volcano monitoring: The Stromboli volcano case study

Abstract We present a joint exploitation of space-borne and ground-based Synthetic Aperture Radar Interferometry (InSAR) and Multi Temporal (MT) InSAR measurements for investigating the Stromboli volcano (Italy) deformation phenomena. In particular, we focus our analysis on three periods: a) the time interval following the 2014 flank eruption, b) the July–August 2019 eruption and c) the following post-eruptive phase. To do this, we take advantage from an unprecedented set of space-borne and ground-based SAR data collected from April 2015 up to November 2019 along two (one ascending and one descending) Sentinel-1 (S-1) tracks, as well as, in the same period, by two ground-based systems installed along the Sciara del Fuoco northern rim. Such data availability permitted us to first characterize the volcano long-term 3D deformation behavior of the pre-eruptive period (April 2015–June 2019), by jointly inverting the space-borne and ground-based InSAR measurements. Then, the GB-SAR measurements allowed us to investigate the sin-eruptive time span (3rd July 2019 – 30th August 2019) which revealed rapid deformation episodes (e.g. more than 30 mm/h just 2 min before the 3rd July 2019 explosion) associated with the eruptive activity, that cannot be detected with the weekly S-1 temporal sampling. Finally, the S-1 measurements permitted to better constrain the post 2019 eruption deformations (31st August 2019 – 5th November 2019), which are mainly located outside the GB-SAR sensed area. The presented results demonstrate the effectiveness of the joint exploitation of the InSAR measurements obtained through satellite and terrestrial SAR systems, highlighting their strong complementarity to map and interpret the deformation phenomena affecting volcanic areas

Editorial Expression of Concern: Coincident locations of rupture nucleation during the 2019 Le Teil earthquake, France and maximum stress change from local cement quarrying

n/

Coincident locations of rupture nucleation during the 2019 Le Teil earthquake, France and maximum stress change from local cement quarrying

AbstractEarthquake occurrence is ultimately controlled by tectonic stress load. Nevertheless, the 2019, Mw = 4.9, Le Teil earthquake in southern France occurred in an area where strain rates are relatively low. Human operations can produce increases in stress load and degradation of strength on nearby active faults, which raises the potential for failure. Here we present estimates of the rupture geometry and source directivity of the Le Teil earthquake based on differential synthetic aperture radar interferometry and seismic data. We find that almost two centuries of mass removal at a nearby cement quarry likely provided the required stress change to hasten the occurrence of the Le Teil earthquake by more than 18,000 years. We suggest that further mass removal in the area might lead to even stronger earthquakes, by activating deeper sectors of the same fault plane