A Study of a Road Landslide in Puerto Rico

Numerous landslides have plagued the construction of a 1.3 mile road sector in the mountainous region of central Puerto Rico. The area is underlain by a sequence of landslide deposits overlying a muddy limestone and hard overconsolidated clayey soils. Landslides have occurred in both cuts and fills that have delayed the road construction for a period of more than two years, bringing as a result, great economic losses for the Puerto Rico Highway Authority. The landslide trigger mechanism has been intimately related to high rainfall, commonly observed in this region. The geotechnical and geological studies performed previous to the construction of this road sector were few and meager. These studies did not recognize the presence of unstable deposits along the road sector alignment. As a result, several large slope failures developed during construction that halted the completion of the road. For investigating the slope failures, detailed geological and geotechnical studies were performed, including monitoring of groundwater levels, rainfall, and slope movements followed by laboratory and slope stability analyses. Remedial measures have been provided in the form of excavation, drainage, and stability berms. Renewal of the road construction with the remedial measures is prompt to start

The discovery, monitoring and environment of SGR J1935+2154

We report on the discovery of a new member of the magnetar class, SGR J1935+2154, and on its timing and spectral properties measured by an extensive observational campaign carried out between July 2014 and March 2015 with Chandra and XMM-Newton (11 pointings). We discovered the spin period of SGR J1935+2154 through the detection of coherent pulsations at a period of about 3.24s. The magnetar is slowing-down at a rate of 1.43(1)x10^{-11} s/s and with a decreasing trend due to a negative second period derivative of -3.5(7)x10^{-19} s/s^2. This implies a surface dipolar magnetic field strength of about 2.2x10^{14} G, a characteristic age of about 3.6kyr and, a spin-down luminosity L_{sd} of about 1.7x10^{34} erg/s. The source spectrum is well modelled by a blackbody with temperature of about 500eV plus a power-law component with photon index of about 2. The source showed a moderate long-term variability, with a flux decay of about 25\% during the first four months since its discovery, and a re-brightening of the same amount during the second four months. The X-ray data were also used to study the source environment. In particular, we discovered a diffuse emission extending on spatial scales from about 1" up to at least 1' around SGR J1935+2154 both in Chandra and XMM-Newton data. This component is constant in flux (at least within uncertainties) and its spectrum is well modelled by a power-law spectrum steeper than that of the pulsar. Though a scattering halo origin seems to be more probable we cannot exclude that part, or all, of the diffuse emission is due to a pulsar wind nebula.Comment: To appear in MNRAS; 10 pages, 3 color figures, 4 table

Study of the functional domains of the PTGS suppressor V2 from geminivirus Beet curly top virus (BCTV)

Geminiviruses constitute a group of plant viruses that infect vegetable crops all over the world. Among the Geminiviridae family, the genera Mastrevirus, Begomovirus and Curtovirus are the most abundant. Suppression of gene silencing is a key mechanism for viral infection in plants. In begomovirus, V2 is a strong posttranscriptional gene silencing suppressor. We recently showed that V2 from curtovirus Beet curly top virus (BCTV) is a PTGS suppressor by impairing the RDR6/SGS3 pathway, as V2 from begomovirus. In order to identify the domains involved in the suppression activity and viral pathogenicity, we performed an alignment of several begomovirus and curtovirus V2 proteins. A protein kinase C (PKC) phosphorylation motif essential for suppression activity in begomovirus (P1) was found in all analysed sequences. We also found similar hydrophobic profiles, with two hydrophobic domains (H1 and H2) followed by a long hydrophilic domain. Then we generated BCTV V2 mutant proteins and performed transient assays in Nicotiana benthamiana plants to test their suppression activity. We also expressed them from a Potato virus X-derived vector to check the symptoms produced. Additionally, their subcellular localization was determined. Finally, we produced BCTV viruses mutated in the different domains and N. benthamiana plants were infected, analysing virus levels and symptoms produced. The results showed that P1, H1 and H2 are involved in the suppression activity and viral pathogenicity.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

On the quest for currencies of science: Field "exchange rates" for citations and Mendeley readership

PurposeThe introduction of “altmetrics” as new tools to analyze scientific impact within the reward system of science has challenged the hegemony of citations as the predominant source for measuring scientific impact. Mendeley readership has been identified as one of the most important altmetric sources, with several features that are similar to citations. The purpose of this paper is to perform an in-depth analysis of the differences and similarities between the distributions of Mendeley readership and citations across fields.Design/methodology/approachThe authors analyze two issues by using in each case a common analytical framework for both metrics: the shape of the distributions of readership and citations, and the field normalization problem generated by differences in citation and readership practices across fields. In the first issue the authors use the characteristic scores and scales method, and in the second the measurement framework introduced in Crespo et al. (2013).FindingsThere are three main results. First, the citations and Mendeley readership distributions exhibit a strikingly similar degree of skewness in all fields. Second, the results on “exchange rates (ERs)” for Mendeley readership empirically supports the possibility of comparing readership counts across fields, as well as the field normalization of readership distributions using ERs as normalization factors. Third, field normalization using field mean readerships as normalization factors leads to comparably good results.Originality/valueThese findings open up challenging new questions, particularly regarding the possibility of obtaining conflicting results from field normalized citation and Mendeley readership indicators; this suggests the need for better determining the role of the two metrics in capturing scientific recognition.Merit, Expertise and Measuremen

A journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel

The heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face, respectively, as well as in other tissues and organs including central nervous system. The TRPV1 channel is a versatile receptor that detects harmful heat, pain, and various internal and external ligands. Hence, it operates as a polymodal sensory channel. Many pathological conditions including neuroinflammation, cancer, psychiatric disorders, and pathological pain, are linked to the abnormal functioning of the TRPV1 in peripheral tissues. Intense biomedical research is underway to discover compounds that can modulate the channel and provide pain relief. The molecular mechanisms underlying temperature sensing remain largely unknown, although they are closely linked to pain transduction. Prolonged exposure to capsaicin generates analgesia, hence numerous capsaicin analogs have been developed to discover efficient analgesics for pain relief. The emergence of in silico tools offered significant techniques for molecular modeling and machine learning algorithms to indentify druggable sites in the channel and for repositioning of current drugs aimed at TRPV1. Here we recapitulate the physiological and pathophysiological functions of the TRPV1 channel, including structural models obtained through cryo-EM, pharmacological compounds tested on TRPV1, and the in silico tools for drug discovery and repositioning