Privacy protocols

Security protocols enable secure communication over insecure channels. Privacy protocols enable private interactions over secure channels. Security protocols set up secure channels using cryptographic primitives. Privacy protocols set up private channels using secure channels. But just like some security protocols can be broken without breaking the underlying cryptography, some privacy protocols can be broken without breaking the underlying security. Such privacy attacks have been used to leverage e-commerce against targeted advertising from the outset; but their depth and scope became apparent only with the overwhelming advent of influence campaigns in politics. The blurred boundaries between privacy protocols and privacy attacks present a new challenge for protocol analysis. Covert channels turn out to be concealed not only below overt channels, but also above: subversions, and the level-below attacks are supplemented by sublimations and the level-above attacks.Comment: 38 pages, 6 figure

Preventing a Thought from Coming to Mind Elicits Increased Right Frontal Beta Just as Stopping Action Does.

In the stop-signal task, an electrophysiological signature of action-stopping is increased early right frontal beta band power for successful vs. failed stop trials. Here we tested whether the requirement to stop an unwanted thought from coming to mind also elicits this signature. We recorded scalp EEG during a Think/No-Think task and a subsequent stop signal task in 42 participants. In the Think/No-Think task, participants first learned word pairs. In a second phase, they received the left-hand word as a reminder and were cued either to retrieve the associated right-hand word ("Think") or to stop retrieval ("No-Think"). At the end of each trial, participants reported whether they had experienced an intrusion of the associated memory. Finally, they received the left-hand reminder word and were asked to recall its associated target. Behaviorally, there was worse final recall for items in the No-Think condition, and decreased intrusions with practice for No-Think trials. For EEG, we reproduced increased early right frontal beta power for successful vs. failed action stopping. Critically, No-Think trials also elicited increased early right frontal beta power and this was stronger for trials without intrusion. These results suggest that preventing a thought from coming to mind also recruits fast prefrontal stopping

Transgenic rabbit models for cardiac disease research.

To study the pathophysiology of human cardiac diseases and to develop novel treatment strategies, complex interactions of cardiac cells on cellular, tissue and whole heart levels need to be considered. As in vitro cell-based models do not depict the complexity of the human heart, animal models are used to obtain insights that can be translated to human diseases. Mice are the most commonly used animals in cardiac research, however, differences in electrophysiological and mechanical cardiac function and a different composition of electrical and contractile proteins limit the transferability of the knowledge gained. Moreover, the small heart size and fast heart rate are major disadvantages. In contrast to rodents, electrophysiological, mechanical, and structural cardiac characteristics of rabbits resemble the human heart more closely, making them particularly suitable as an animal model for cardiac disease research. In this review, various methodological approaches for the generation of transgenic rabbits for cardiac disease research - such as pronuclear microinjection, the sleeping beauty transposon system and novel genome editing methods (ZFN and CRISPR/Cas9) - will be discussed. In the second section, we will introduce the different currently available transgenic rabbit models for monogenic cardiac diseases (such as long-QT syndrome, short-QT syndrome, and hypertrophic cardiomyopathy) in detail, especially in regards to their utility to increase the understanding of pathophysiological disease-mechanisms and novel treatment options

Sleep and physical activity: results from a long-term actigraphy study in adolescents.

PURPOSE Research to date suggests that physical activity is associated with improved sleep, but studies have predominantly relied on self-report measures and have not accounted for school day/free day variability. To address these gaps in the literature, the aim of the present study was to (a) quantify physical activity in adolescents using long-term daily actigraphy measurement and (b) to examine the association between actigraphically assessed steps and sleep behavior in a sample of healthy adolescents. To be able to capture intra- and inter-individual differences in the daily physical activity of adolescents, we examined within as well as between subjects effects and its association with sleep. METHODS Fifty adolescents between 10 and 14 years of age were included in the present study. In total 5989 days of actigraphy measurement (average of 119 ± 40 days per participant; range = 39-195 days) were analyzed. We use multilevel modeling to disentangle the within and between subject effects of physical activity on sleep. In this way, we examine within an individual, the association between steps during the day and subsequent sleep on a day-to-day basis. On the other hand, our between subjects' analysis allows us to ascertain whether individuals with more overall physical activity have better sleep. RESULTS Within a subject more steps on school and free days were associated with later bed times on school and free days as well as later rise times on school days only. On the other hand, comparing between subjects' effects, more steps were associated with lower sleep efficiency on free and school days. No other significant associations were found for the other sleep variables. CONCLUSION Our results obtained through objective and long-term measurement of both sleep and number of steps suggest weak or non-significant associations between these measures for most sleep variables. We emphasize the importance of the methodology and the separation of within subject from between subject features when examining the relationship between physical activity and sleep

Decoupling Functional and Morphological Convergence, the Study Case of Fossorial Mammalia

Morphological similarity between biological structures in phylogenetically distant species is usually regarded as evidence of convergent evolution. Yet, phenotypic similarity is not always a sign of natural selection acting on a particular trait, therefore adaptation to similar conditions may fail to generate convergent lineages. Herein we tested whether convergent evolution occurred in the humerus of fossorial mammals, one of the most derived biological structures among mammals. Clades adapting to digging kinematics possess unusual, by mammalian standards, humeral shapes. The application of a new, computationally fast morphological test revealed a single significant instance of convergence pertaining to the Japanese fossorial moles (Mogera) and the North-American fossorial moles (Scalopini). Yet, the pattern only manifests when trade-off performance data (derived from finite element analysis) are added to shape data. This result indicates that fossorial mammals have found multiple solutions to the same adaptive challenge, independently moving around multiple adaptive peaks. This study suggests the importance of accounting for functional trade-off measures when studying morpho-functional convergence. We revealed that fossorial mammals, a classic example of convergent evolution, evolved multiple strategies to exploit the subterranean ecotope, characterized by different functional trade-offs rather than converging toward a single adaptive optimum

A cosmopolitan temptation

For some, the transnationalization of political action and communicative space in the European Union heralds an emergent cosmopolitan order. Need that be so? There are supranational institutions in the EU as well as transnational political and cultural spaces and cross-border communicative flows. However, the Union's member states remain key controllers of citizenship rights and purveyors of collective identities. And for many purposes they still maintain strongly bounded national public spheres. Because the EU's overall character as a polity remains unresolved, this has consequences for the organization of communicative spaces. The EU is a field of tensions and contradictions that is inescapably rooted in institutional realities. Wishful thinking about cosmopolitanism can get in the way of clear analysis

The Grizzly, March 25, 2004

Ursinus College Bookstore now Under New Management • Bombing in Madrid Causes Concern for Students\u27 Safety • The Real World Said Goodbye to Philadelphia • It\u27s Registration Time Again • Opinions: How to Land that Perfect Job; Good Food at the Bamboo Club • Alternative Spring Break Group Builds Home in Georgia • Airband 2004 • Liberty Thrift Shop • Softball Team Dominates • Honors Rolling in for Stantonhttps://digitalcommons.ursinus.edu/grizzlynews/1556/thumbnail.jp

The Grizzly, April 29, 2004

As the School Years Ends, The Search for Jobs Begins • Life-Changing Volunteer Work Found At the Clinic • Fad Diets: Do They Work? • Opinions: Chronic Back Pain: Ouch!; Lacking Luster (Again) at La Fontana; Is Donald Trump the Ideal Boss?; Eating Your Veggies Now More Appetizing than Mom Tried to Make it • Staff Spotlight: Jamal Elliot • Ursinus Students Put Learning Into Practice at Model U.N. • Goldwater Scholar Kari Baker • Softball Team Rolls Past Muhlenberg • Leadership: A Key Ingredient in the Success of the Men\u27s Baseball Team • Final Exam Schedulehttps://digitalcommons.ursinus.edu/grizzlynews/1561/thumbnail.jp

The Grizzly, April 8, 2004

Students Find a New Way to Connect • Democrats Club Active in Upcoming Elections • Ursinus and USGA: Who We Are • The 9/11 Investigation: Rice vs. Clarke • Opinions: Unhappy Happy Hour ; UC Chess Tournament; Dine Like the Irish at Kildare\u27s • Student Spotlight: Sarah Kauffman Exposed • Save the Speaker\u27s House • Pew Lecture: Peter Rose Hypnotizes Students with his Work • Young Nucleus Coming Together for UC Men\u27s Lacrosse • Women\u27s Lacrosse Working to Keep Season Alive • Women\u27s Rugby Hanging in Toughhttps://digitalcommons.ursinus.edu/grizzlynews/1558/thumbnail.jp