502 research outputs found
Knowles, Kolb, & Google: Prior Learning Assessment as a Model for 21st-Century Learning
For adult students who have committed anew to completing a four-year bachelor’s degree, prior learning assessment (PLA) can be a surprising bonus that affirms their previous life experiences, shortens the degree completion pathway, and ultimately lowers tuition dollars. What students typically do not realize as they enter the process, however, is that PLA can be much more than simply a road to a diploma: When designed with an intentional framework of andragogical principles and experiential emphases, PLA can provide adult students with a lifelong model for self-assessment and higher-level learning in a 21st-century Google era
Lapatinib in combination with capecitabine in the management of ErbB2-positive (HER2-positive) advanced breast cancer
Lapatinib is an oral, reversible, dual inhibitor of epidermal growth factor receptor ErbB1 (EGFR) and human epidermal growth factor receptor type 2 ErbB2 (HER2). Results of a phase III study comparing lapatinib plus capecitabine with capecitabine alone in women with ErbB2-overexpressing advanced breast cancer previously treated with an anthracycline, a taxane, and trastuzumab were reported early based on superiority of the combination in prolonging time to tumor progression (TTP). An updated analysis in 399 women supports the earlier findings. In this updated analysis, TTP (hazard ratio [HR] 0.57) favored lapatinib plus capecitabine. Survival trended in favor of the combination. The incidence of cardiac events was numerically higher in the combination arm (5 cases in the combination arm, 2 cases in the monotherapy arm)
How Will the Future of Work Shape Osh Research and Practice? a Workshop Summary
Growth of the information economy and globalization of labor markets will be marked by exponential growth in emerging technologies that will cause considerable disruption of the social and economic sectors that drive the global job market. These disruptions will alter the way we work, where we work, and will be further affected by the changing demographic characteristics and level of training of the available workforce. These changes will likely result in scenarios where existing workplace hazards are exacerbated and new hazards with unknown health effects are created. The pace of these changes heralds an urgent need for a proactive approach to understand the potential effects new and emerging workplace hazards will have on worker health, safety, and well-being. As employers increasingly rely on non-standard work arrangements, research is needed to better understand the work organization and employment models that best support decent work and improved worker health, safety, and well-being. This need has been made more acute by the SARS-CoV-2 global pandemic that has resulted in dramatic changes in employment patterns, millions of lost jobs, an erosion of many economic sectors, and widespread disparities which further challenge occupational safety and health (OSH) systems to ensure a healthy and productive workplace. to help identify new research approaches to address OSH challenges in the future, a virtual workshop was organized in June 2020 with leading experts in the fields of OSH, well-being, research methods, mental health, economics, and life-course analysis. A paradigm shift will be needed for OSH research in the future of work that embraces key stakeholders and thinks differently about research that will improve lives of workers and enhance enterprise success. A more transdisciplinary approach to research will be needed that integrates the skills of traditional and non-traditional OSH research disciplines, as well as broader research methods that support the transdisciplinary character of an expanded OSH paradigm. This article provides a summary of the presentations, discussion, and recommendations that will inform the agenda of the Expanded Focus for Occupational Safety and Health (Ex4OSH) International Conference, planned for December 2021
Weight‐Related Differences in Salience, Default Mode, and Executive Function Network Connectivity in Adolescents
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156135/2/oby22853.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156135/1/oby22853_am.pd
Policy Recommendations for Meeting the Grand Challenge to Eradicate Social Isolation
This brief was created forSocial Innovation for America’s Renewal, a policy conference organized by the Center for Social Development in collaboration with the American Academy of Social Work & Social Welfare, which is leading theGrand Challenges for Social Work initiative to champion social progress. The conference site includes links to speeches, presentations, and a full list of the policy briefs
Acute Liver Failure (ALF) in Pregnancy: How Much Is Pregnancy Related?
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163471/1/hep31144.pd
The masses of Local Group dwarf spheroidal galaxies: The death of the universal mass profile
We investigate the claim that all dwarf spheroidal galaxies (dSphs) reside
within halos that share a common, universal mass profile as has been derived
for dSphs of the Galaxy. By folding in kinematic information for 25 Andromeda
dSphs, more than doubling the previous sample size, we find that a singular
mass profile can not be found to fit all the observations well. Further, the
best-fit dark matter density profile measured for solely the Milky Way dSphs is
marginally discrepant (at just beyond the 1 sigma level) with that of the
Andromeda dSphs, where a profile with lower maximum circular velocity, and
hence mass, is preferred. The agreement is significantly better when three
extreme Andromeda outliers, And XIX, XXI and XXV, all of which have large
half-light radii (>600pc) and low velocity dispersions (sigma_v < 5km/s) are
omitted from the sample. We argue that the unusual properties of these outliers
are likely caused by tidal interactions with the host galaxy.Comment: ApJ in press, 16 pages, 7 figures. Updated to address referee
comment
A kinematic study of the Andromeda dwarf spheroidal system
We present a homogeneous kinematic analysis of red giant branch stars within
18 of the 28 Andromeda dwarf spheroidal (dSph) galaxies, obtained using the
Keck I LRIS and Keck II DEIMOS spectrographs. Based on their g-i colors (taken
with the CFHT MegaCam imager), physical positions on the sky, and radial
velocities, we assign probabilities of dSph membership to each observed star.
Using this information, the velocity dispersions, central masses and central
densities of the dark matter halos are calculated for these objects, and
compared with the properties of the Milky Way dSph population. We also measure
the average metallicity ([Fe/H]) from the co-added spectra of member stars for
each M31 dSph and find that they are consistent with the trend of decreasing
[Fe/H] with luminosity observed in the Milky Way population. We find that three
of our studied M31 dSphs appear as significant outliers in terms of their
central velocity dispersion, And XIX, XXI and XXV, all of which have large
half-light radii (>700 pc) and low velocity dispersions (sigma_v<5 km/s). In
addition, And XXV has a mass-to-light ratio within its half-light radius of
just [M/L]_{half}=10.3^{+7.0}_{-6.7}, making it consistent with a simple
stellar system with no appreciable dark matter component within its 1 sigma
uncertainties. We suggest that the structure of the dark matter halos of these
outliers have been significantly altered by tides.Comment: 41 pages, 23 figures. Accepted for publication in Ap
Expanding the Focus of Occupational Safety and Health: Lessons From a Series of Linked Scientific Meetings
There is widespread recognition that the world of work is changing, and agreement is growing that the occupational safety and health (OSH) field must change to contribute to the protection of workers now and in the future. Discourse on the evolution of OSH has been active for many decades, but formalized support of an expanded focus for OSH has greatly increased over the past 20 years. Development of approaches such as the National Institute for Occupational Safety and Health (NIOSH)\u27s total Worker Healt
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