The relationship between Stryd power and running economy in well-trained distance runners

A novel running wearable called the Stryd Summit footpod attaches to a runner’s right or left shoe and measures running power output. The developers of the product purport that the footpod’s power and form power measures may correlate with metabolic data gathered in a lab. PURPOSE: Explore the relationship between power output and running economy at threshold pace. METHODS: Seventeen well-trained distance runners, 9 males and 8 females, completed a running protocol at threshold pace. Participants ran two discontinuous four-minute stages: one with their self-selected cadence (SS), and one with cadence lowered by 10% (LC). Metabolic data, power, and form power output were recorded for each cadence condition. RESULTS: Average self-selected cadence was 179.60 strides·min-1 (±8.43), while lowered cadence was 172.54 strides·min-1 (±9.46). Average change in cadence from SS to LC was 3.93%. The average running economy expressed in terms of oxygen cost (±SD) at self-selected cadence was 201.58 ml·kg-1·km-1 (±12.80), and at lowered cadence was 204.48 ml·kg-1·km-1 (±11.48). Average caloric unit cost at SS was 1.05 kcal·kg-1·km-1 (±0.07), and at LC was 1.06 kcal·kg-1·km-1 (±0.06). Average power at SS was 4.37 W·kg-1 (±0.48), and at LC was 4.42 W·kg-1 (±0.49). Average form power at SS was 1.07 W·kg-1 (±0.09), and at LC was 1.13 W·kg-1 (±0.10). CONCLUSIONS: The present findings show that measures of running economy expressed in terms of oxygen cost and caloric unit cost are positively correlated with Stryd’s power and form power measures

Institutional and Conceptual Barriers to Climate Change Adaptation for Coastal Cultural Heritage

Climate change is increasing the speed at which tangible coastal cultural heritage is changing in character or being lost through weathering, erosion, and inundation. Damages to coastal archeological sites, loss of access to historical sites, and the alteration of cultural landscapes will force changes in the way researchers can study sites, tourists can enjoy places, and descendant communities who have lived in particular areas for time immemorial, and local community members can utilize and relate to landscapes. In the USA, the National Park Service is a primary coastal cultural resource management organization. The National Park Service has been working on climate change adaptation for cultural resources for over a decade; however, there are few examples of parks in which long range climate change adaptation plans for cultural resources have been implemented. Building from 20 semi-structured interviews with cultural resource managers in three parks, we found that institutional structures within the National Park Service, as well as historical conceptual framings specific to the research, recreational, and interpretive values of cultural resources act as barriers to managers’ ability to design and implement climate change adaptation plans. Institutional barriers managers discussed include the dependence of climate change adaptation decisions partnership projects and the leveraging of budgetary and staff resources within NPS that may affect climate change adaptation capacity. We found that park managers often saw impacts in parks that may be associated with climate change, but found it difficult to separate normal maintenance from climate change affected deterioration, which may lead to status quo management actions rather than revised planning for a changing future regime. Conceptual barriers managers discussed revealed a conflict between preservation needs of research versus interpretive uses and while NPS guidance recommends prioritization of cultural resources for preservation at the park level, regional managers were more focused on this topic than park managers. As NPS moves forward with climate change adaptation planning, opportunities to develop and improve cultural resource preservation with new technologies, improved prioritization schemes, and include public input in resource preservation may help coastal managers overcome these barriers

Global Health Uganda 2018: Where are we now?

Introduction: OSU-COM students and physicians have been traveling to Sister Rosemary's in Gulu, Uganda to both learn about and assist in Ugandan healthcare since 2015. There have been many positive changes on Sister Rosemary's compound with the addition of a birthing center and expansion of the health care clinic throughout the years. These additions have improved access to health care in Gulu and surrounding towns. We set out to analyze the current prevalence of disease and demographics in Gulu and Atiak in order to better understand and help the Ugandan people. Our research allows for tailoring of future health care education programs and distribution of research on future trips.Research Question: What is the current disease prevalence, demographics, and risk factors for most commonly seen infectious diseases?Study Design: Chart ReviewMethods: Data collection occurred through a standardized SOAP note created prior to departure to insure accurate data collection. All statistical analysis was done using excel.Results: Our team saw roughly 450 patients and our data demonstrates that among the most prevalent disorders treated were gastroesophageal reflux disease, musculoskeletal pain, parasitosis, and upper respiratory infections.Conclusion: This information allows us to be better prepared on future trips with proper medications and resources to best aid the Ugandan people. Future research topics to investigate would be to analyze the progression of disease throughout the years at Sister Rosemary's and other locations affiliated with the global health program

Standardized system for ballistic missile guidance data analysis

Thesis (M. Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.Includes bibliographical references (p. 37).This thesis had the goals of standardizing and automating guidance data analysis at The Charles Stark Draper Laboratory, Inc. (Draper). This was accomplished via, the first ever machine understandable knowledge of Portable Engineering Testing Stations (PETS) variables located in a comprehensive MySQL database. Automation was achieved via a MATLAB program designed to be flexible for a wide variety of inputs and outputs. The standardization required time-consuming interface analysis and a tedious programming effort, but has proved to be successful and is already streamlining the data collection and analysis process for another program at Draper.by Austin Casey McNurlen.M.Eng.and S.B

Assessment of depth of sedation using Bispectral Index™ monitoring in patients with severe traumatic brain injury in UK intensive care units

Peer reviewe

Use of facility assessment data to improve reproductive health service delivery in the Democratic Republic of the Congo

Background: Prolonged exposure to war has severely impacted the provision of health services in the Democratic Republic of the Congo (DRC). Health infrastructure has been destroyed, health workers have fled and government support to health care services has been made difficult by ongoing conflict. Poor reproductive health (RH) indicators illustrate the effect that the prolonged crisis in DRC has had on the on the reproductive health (RH) of Congolese women. In 2007, with support from the RAISE Initiative, the International Rescue Committee (IRC) and CARE conducted baseline assessments of public hospitals to evaluate their capacities to meet the RH needs of the local populations and to determine availability, utilization and quality of RH services including emergency obstetric care (EmOC) and family planning (FP). Methods: Data were collected from facility assessments at nine general referral hospitals in five provinces in the DRC during March, April and November 2007. Interviews, observation and clinical record review were used to assess the general infrastructure, EmOC and FP services provided, and the infection prevention environment in each of the facilities. Results: None of the nine hospitals met the criteria for classification as an EmOC facility (either basic or comprehensive). Most facilities lacked any FP services. Shortage of trained staff, essential supplies and medicines and poor infection prevention practices were consistently documented. All facilities had poor systems for routine monitoring of RH services, especially with regard to EmOC. Conclusions: Women's lives can be saved and their well-being improved with functioning RH services. As the DRC stabilizes, IRC and CARE in partnership with the local Ministry of Health and other service provision partners are improving RH services by: 1) providing necessary equipment and renovations to health facilities; 2) improving supply management systems; 3) providing comprehensive competency-based training for health providers in RH and infection prevention; 4) improving referral systems to the hospitals; 5) advocating for changes in national RH policies and protocols; and 6) providing technical assistance for monitoring and evaluation of key RH indicators. Together, these initiatives will improve the quality and accessibility of RH services in the DRC - services which are urgently needed and to which Congolese women are entitled by international human rights law

Repeated Low-Level Blast Exposure Alters Urinary And Serum Metabolites

Repeated exposure to low-level blast overpressures can produce biological changes and clinical sequelae that resemble mild traumatic brain injury (TBI). While recent efforts have revealed several protein biomarkers for axonal injury during repetitive blast exposure, this study aims to explore potential small molecule biomarkers of brain injury during repeated blast exposure. This study evaluated a panel of ten small molecule metabolites involved in neurotransmission, oxidative stress, and energy metabolism in the urine and serum of military personnel (n = 27) conducting breacher training with repeated exposure to low-level blasts. The metabolites were analyzed using HPLC—tandem mass spectrometry, and the Wilcoxon signed-rank test was used for statistical analysis to compare the levels of pre-blast and post-blast exposures. Urinary levels of homovanillic acid (p \u3c 0.0001), linoleic acid (p = 0.0030), glutamate (p = 0.0027), and serum N-acetylaspartic acid (p = 0.0006) were found to be significantly altered following repeated blast exposure. Homovanillic acid concentration decreased continuously with subsequent repeat exposure. These results suggest that repeated low-level blast exposures can produce measurable changes in urine and serum metabolites that may aid in identifying individuals at increased risk of sustaining a TBI. Larger clinical studies are needed to extend the generalizability of these findings

Effects of seasonal spawning closures on pike (<i>Esox lucius</i> L.) and perch (<i>Perca fluviatilis</i> L.) catches and coastal food webs in the western Baltic Sea

Marine protected areas have become one of the main tools in the battle to curb marine biodiversity loss and habitat degradation. Yet, implementation of permanent fishery closures has often generated resource user conflicts that ultimately undermine conservation goals. Here we assessed the influence of an alternative and often more accepted measure – seasonal fish spawning closures – on large predatory fish and coastal food webs in the western Baltic Sea (Sweden). In spring 2017, we conducted a multivariable field survey in 11 seasonal closures and 11 paired references areas open to fishing. In each area, pike was sampled through angling, and perch and mesopredators through gillnet surveys. To assess trophic cascades, we measured zooplankton abundance and loss of tethered gammarids from predation. Catches per unit effort of northern pike (Esox lucius) – the main target species in recreational fisheries – were ca. 2.5 times higher per unit effort in closures than reference areas; an effect that may be caused by higher abundance and/or higher catchability of pike in the absence of fishing. Catch and weight per unit effort of the more common predator European perch (Perca fluviatilus), and the mesopredators roach (Rutilus rutilus) and three-spined stickleback (Gasterosteus aculeatus) in survey nets were, however, unaffected by closures. Moreover, a previously hypothesized trophic cascade from perch to zooplankton via three-spined stickleback was supported by the analyses, but appeared independent of closures. Yet, predation risk for tethered gammarid amphipods (a prey of stickleback and an important grazer on macroalgae) was three times higher in fished areas than in closures; a cascading closure effect that may potentially be caused by small predatory fish being less active in protected areas to avoid pike predation. Overall, our results suggest that spawning closures impact pike abundance and/or behavior and could help limit the effects of fishing, but that more research is needed to disentangle i) what mechanism(s) that underlie the protection effect on pike catches, ii) the apparently weaker closure impacts on other fish species, as well as iii) the potential for cascading effects on lower trophic levels. Therefore, new seasonal spawning closures should be implemented in addition to (and not instead of) much-needed permanent closures, which have well-known effects on the wider ecosystem.</p

Effects of seasonal spawning closures on pike (Esox lucius L.) and perch (Percafluviatilis L.) catches and coastal food webs in the western Baltic Sea

Marine protected areas have become one of the main tools in the battle to curb marine biodiversity loss and habitat degradation. Yet, implementation of permanent fishery closures has often generated resource user conflicts that ultimately undermine conservation goals. Here we assessed the influence of an alternative and often more accepted measure - seasonal fish spawning closures - on large predatory fish and coastal food webs in the western Baltic Sea (Sweden). In spring 2017, we conducted a multivariable field survey in 11 seasonal closures and 11 paired references areas open to fishing. In each area, pike was sampled through angling, and perch and mesopredators through gillnet surveys. To assess trophic cascades, we measured zooplankton abun-dance and loss of tethered gammarids from predation. Catches per unit effort of northern pike (Esox lucius) - the main target species in recreational fisheries - were ca. 2.5 times higher per unit effort in closures than reference areas; an effect that may be caused by higher abundance and/or higher catchability of pike in the absence of fishing. Catch and weight per unit effort of the more common predator European perch (Perca fluviatilus), and the mesopredators roach (Rutilus rutilus) and three-spined stickleback (Gasterosteus aculeatus) in survey nets were, however, unaffected by closures. Moreover, a previously hypothesized trophic cascade from perch to zooplankton via three-spined stickleback was supported by the analyses, but appeared independent of closures. Yet, predation risk for tethered gammarid amphipods (a prey of stickleback and an important grazer on mac-roalgae) was three times higher in fished areas than in closures; a cascading closure effect that may potentially be caused by small predatory fish being less active in protected areas to avoid pike predation. Overall, our results suggest that spawning closures impact pike abundance and/or behavior and could help limit the effects of fishing, but that more research is needed to disentangle i) what mechanism(s) that underlie the protection effect on pike catches, ii) the apparently weaker closure impacts on other fish species, as well as iii) the potential for cascading effects on lower trophic levels. Therefore, new seasonal spawning closures should be implemented in addition to (and not instead of) much-needed permanent closures, which have well-known effects on the wider ecosystem

Phase I dose escalation trial of stereotactic radiotherapy prior to robotic prostatectomy in high risk prostate cancer

BACKGROUND: The aim of the study was to investigate the safety of combining preoperative stereotactic body radiotherapy (SBRT) with robotic radical prostatectomy (RP) for high risk prostate cancer (HRCaP). Many patients with HRCaP will require adjuvant or salvage radiotherapy after RP. The addition of preoperative SBRT before RP may spare patients from subsequent prolonged courses of RT. MATERIALS AND METHODS: Eligible patients had NCCN HRCaP and received a total of 25 Gy or 30 Gy in five daily fractions of SBRT to the prostate and seminal vesicles followed by robotic RP with pelvic lymphadenectomy 31-45 days later. The primary endpoint was prevalence of acute genitourinary (GU) and gastrointestinal (GI) toxicity. Secondary endpoints were patient-reported quality of life (QOL) and biochemical recurrence (BcR) RESULTS: Three patients received preoperative SBRT to 25 Gy and four received 30 Gy. Median follow-up was 18 months. Highest toxicity was grade 2 and 3 in six (85.7%) and one (14.3%) patients, respectively. All patients developed grade 2 erectile dysfunction and 4 of 7 (57%) developed grade 2 urinary incontinence (UI) within a month after surgery. One patient developed acute grade 3 UI, but there was no grade ≥ 4 toxicity. One patient experienced acute grade 2 hemorrhoidal bleeding. On QOL, acute GU complaints were common and peaked within 3 months. Bowel symptoms were mild. Two patients with pN+ experienced BcR. CONCLUSIONS: Preoperative SBRT before robotic RP in HRCaP is feasible and safe.  The severity of acute GU toxicity with preoperative SBRT may be worse than RP alone, while bowel toxicity was mild