Impact of COVID-19 on maxillofacial surgery practice: a worldwide survey

The outbreak of coronavirus disease 2019 (COVID-19) is rapidly changing our habits. To date, April 12, 2020, the virus has reached 209 nations, affecting 1.8 million people and causing more than 110,000 deaths. Maxillofacial surgery represents an example of a specialty that has had to adapt to this outbreak, because of the subspecialties of oncology and traumatology. The aim of this study was to examine the effect of this outbreak on the specialty of maxillofacial surgery and how the current situation is being managed on a worldwide scale. To achieve this goal, the authors developed an anonymous questionnaire which was posted on the internet and also sent to maxillofacial surgeons around the globe using membership lists from various subspecialty associations. The questionnaire asked for information about the COVID-19 situation in the respondent's country and in their workplace, and what changes they were facing in their practices in light of the outbreak. The objective was not only to collect and analyse data, but also to highlight what the specialty is facing and how it is handling the situation, in the hope that this information will be useful as a reference in the future, not only for this specialty, but also for others, should COVID-19 or a similar global threat arise again

The impact of an ideal dynamic building envelope on the energy performance of low energy office buildings

This paper shows the results of a research activity aimed at assessing the advantages of an ideal adaptive building skin over conventional building envelope systems. The basic idea underlying the research consists in imagining an ideal building envelope system characterised by the capability of continuously changing (within a certain range) some of its thermo-physical and optical properties. The reason for the continuous tuning of thermo-physical and optical properties lies in the assumption that an optimised (fixed) configuration, where the properties do not change over time, is not able to minimise the total energy demand of the building at each moment. For the sake of this purpose, an ideal dynamic WWR (Window-to-Wall Ratio) building envelope system for low energy office buildings was modelled and simulated. An integrated thermal-lighting building simulation tool was used. The energy performance of such a system was then analysed and compared against the performance of a conventional façade realised with best-available technologies. The results of the investigation demonstrated the advantages of a dynamic WWR configuration over a static one. However, the improvements achieved in energy demand were lower than expected. This behaviour is strictly related to the configuration of the building used as a reference, which already showed a very high energy performance. Limitations presented by the research method are also briefly pointed out and discussed

Architectural self-fabrication

The paper will focus on the role of computational design and digital fabrication in the processes of urban and architectural self-regeneration of existing infrastructures and buildings. The Architectural Fabrication research agenda takes inspiration from some of the concepts mentioned in Christopher Alexander’s essay ‘Systems generating systems’ (1968). It aims at introducing ways in which systems thinking and computer aided manufacturing can be most directly applied to the built environment. Hacking architectural spaces, by evolving their genetic spatial and structural codes, is developing the idea of optimizing resources involving inhabitants rather than generating other top down architectural solutions. During the last decades (starting from the book of Mario Carpo, ‘The Digital Turn in Architecture’) the digital shift in architectural design has generated a new discipline with the aim to define an innovative way to bridge the notion of nature with the one of teknè. From such a cultural milieu many research agenda were focusing on the concepts of morphogenesis and evolutionary thinking inspired by the work of French philosophers Gilles Deleuze and Felix Guattari based on the theory of complex systems. Despite this interest in bridging an evolutionary approach with the notion of emergent technologies in architecture (well described in the book ‘The Architecture of Emergence’ of Michael Weinstock) only a very few researchers have investigated on the potential of computational design as a driver for the ecological rehabilitation of existing infrastructures. As a matter of fact, the computational designers were so worried to claim for a new aesthetical identity of their discipline while a new opportunity was emerging for applying this evolutionary approach in order to hack existing structures. The idea of living infrastructures is related to the possibility of developing contextual algorithms in order to customize standard solutions with a post-human process that creates diversified spatial configurations out of very rigid organizational systems. Therefore, the paper will also talk about the Hacking Gomorra project as a possible paradigm of experimenting a 3D printing protocol for the environmental rehabilitation of a mega-structural housing building in Naples (Italy)

Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1

During angiogenic remodeling, Ang-1, the ligand of Tie2 tyrosine kinase, is involved in vessel sprouting and stabilization through unclear effects on nascent capillaries and mural cells. In our study, we hypothesized that the Ang-1/Tie2 system could crosstalk with integrins, and be influenced by the dynamic interactions between extracellular matrix and endothelial cells (ECs). Here, we show that α5β1 specifically sensitizes and modulates Tie2 receptor activation and signaling, allowing EC survival at low concentrations of Ang-1 and inducing persistent EC motility. Tie2 and α5β1 interact constitutively; α5β1 binding to fibronectin increases this association, whereas Ang-1 stimulation recruits p85 and FAK to this complex. Furthermore, we demonstrate that Ang-1 is able to mediate selectively α5β1 outside-in FAK phosphorylation. Thus, Ang-1 triggers signaling pathways through Tie2 and α5β1 receptors that could crosstalk when Tie2/α5β1 interaction occurs in ECs plated on fibronectin. By using blocking antibodies, we consistently found that α5β1, but not αvβ3 activation, is essential to Ang-1-dependent angiogenesis in vivo. © The Rockefeller University Press

Assessing influence factors on daily ammonia and greenhouse gas concentrations from an open-sided cubicle barn in hot mediterranean climate

Measurement of gas concentrations constitutes basic knowledge for the computation of emissions from livestock buildings. Although it is well known that hot climate conditions increase gas emissions, in the literature the relation between gas concentrations from open barns and animalrelated parameters has not been investigated yet. This study aimed at filling this gap by evaluating daily gas concentrations within an open-sided barn in hot Mediterranean climate. The influence of microclimatic parameters (MC) and cow behavior and barn management (CBBM) were evaluated for ammonia (NH3 ), methane (CH4 ), and carbon dioxide (CO2 ) concentrations. Results showed that both MC and CBBM affected concentrations of NH3 (p < 0.02), CH4 (p < 0.001), and CO2 (p < 0.001). Higher values of NH3 concentration were detected during the cleaning of the floor by a tractor with scraper, whereas the lowest NH3 concentrations were recorded during animal lying behavior. Measured values of CO2 and CH4 were highly correlated (C = 0.87–0.89) due to the same sources of production (i.e., digestion and respiration). The different management of the cooling systems during the two observation periods reduced significantly CH4 concentrations in the barn when the cooling system in the feeding area was switched off. Based on methodological choices due to the specific barn typology, parameters related to animals can provide information on the variation of gas concentrations in the barn environment in hot climate conditions

Integrins: A flexible platform for endothelial vascular tyrosine kinase receptors.

Compared to lower metazoans, vertebrates built up an exclusively new set of adhesion-related genes involved in the tissue development and in their functions. They include a large variety of extracellular matrix proteins and their heterodimeric integrin adhesive receptors. Integrins control the adhesive state of the cell through complex molecular mechanisms. Outside-in signalling informs the cell about the extracellular matrix environment, while Inside-out signalling results in changes in integrin functional activity. In the last 10 years it has well established a reciprocal integration of signals originating from integrins and receptors for soluble growth factors. This review summarizes the current understanding of this connection in vascular endothelial cells and highlights how integrins regulate a genetic program triggered by angiogenic inducers during embryo development and in adult life

Improving natural ventilation in renovated free-stall barns for dairy cows: Optimized building solutions by using a validated computational fluid dynamics model

Natural ventilation is the most used system to create suitable conditions, removing gases, introducing oxygen in livestock buildings. Its efficiency depends on several factors and above all on the number, the dimensions and the position of wall openings and internal layout of livestock buildings. The aim of this research was to develop optimized layout solutions for improving natural ventilation effectiveness in free-stall barns for dairy cows by using a CFD approach. A validated computational fluid dynamics (CFD) model was applied in a case study which is highly representative of building interventions for renovating the layout of free-stall barns for dairy cows located in an area of the Mediterranean basin. Firstly, dairy cow behaviour was analysed by visual examination of time-lapse video-recordings. Then, simulations were carried out by using the validated CFD model and changing the position of internal and external building elements (i.e., internal office and external buildings for milking) in order to find the best condition for the thermal comfort of the animals. The results showed that the best conditions were recorded for a new configuration of the building in terms of air velocity distribution within the resting area, the service alley and the feeding alley for dairy cows, and in the pens for calves. In this new layout, the office areas and the north-west wall openings were located by mirroring them along the transversal axis of the barn. Therefore, the CFD approach proposed in this study could be used during the design phase, as a decision support system aimed at improving the natural ventilation within the barn

Potential biogas production from agricultural by-products in Sicily. A case study of citrus pulp and olive pomace

Renewable energy sources represent a suitable alternative to conventional fossil fuels, due to the possible advantages in terms of environmental impact reduction. Anaerobic digestion of biomasses could be considered an environmental friendly way to treat and revalorise large amounts of by-products from farming industries because it ensures both pollution control and energy recovery. Therefore, the objective of this study was to define a methodology for evaluating the potential biogas production available from citrus pulp and olive pomace, which are suitable agricultural by-products for biogas production. In the first phase of the study, the spatial distribution of both olive and citrus-producing areas was analysed in Sicily, a geographical area of the Mediterranean basin highly representative of these types of cultivation. Then, a GIS-based model, which had been previously defined and utilised to evaluate the amount of citrus pulp and olive pomace production, was applied to this case study. Based on the results obtained for the different provinces of Sicily, the province of Catania was chosen as the study area of this work since it showed the highest production of both citrus pulp and olive pomace. Therefore, a further analysis regarded the quantification of olive pomace and citrus pulp at municipal level. The results of this analysis showed that the total amount of available citrus pulp and olive pomace corresponded theoretically to about 11,102,469 Nm3/year biogas. Finally, the methodology adopted in this study made it possible to identify suitable areas for the development of new biogas plants by considering both the spatial distribution of the olive and citrus growing areas and the locations of the existing processing industries

Development of a CFD model to simulate natural ventilation in a semi-open free-stall barn for dairy cows

Natural ventilation is the most common passive cooling system in livestock buildings. The aim of this research is to assess airflow distribution inside a free-stall barn for dairy cows by computational fluid dynamics (CFD) modelling and simulation. The model is validated by using the average values of experimental data acquired in a free-stall barn, which is considered relevant because it is located in a region characterised by hot climate conditions during the summer that could induce animal heat stress. Simulations are carried out in steady-state conditions, and simulated data are validated by the average values of air velocity measurements. Since the modelled air velocity distribution in the barn fits the real one well, the CFD model is considered reliable to simulate other conditions. The application of the proposed CFD model in the simulation of specific building design alternatives could be aimed at studying the related airflow distribution in order to find the best configuration

Kernel density estimation analyses based on a low power-global positioning system for monitoring environmental issues of grazing cattle

The use of wearable sensors that record animal activity in intensive livestock systems has become more and more frequent for both early detection of diseases and improving production quality. Their application may also be significant in extensive livestock systems, with infrequent farmer-to-animal contact. The pre-sent study aimed to prove the feasibility of a novel automatic sys- tem for locating and tracking cows in extensive livestock systems based on space-time data provided by a low-power global positioning system (LP-GPS). The information was used to study the pasture exploitation by the herd for modelling the environmental impacts of extensive livestock systems through geographical information systems (GIS). A customised device, placed within a rectangular PVC case compatible with the collar usually worn by animals, was equipped with an LP-GPS omnidirectional system, an integrated SigFox communication system, and a power supply. The experimental trial was conducted in an existing semi-natural pasture characterised by good pasture allowance and cultivated grazing areas. Ten cows were embedded with LP-GPS collars, and the data, i.e., geographical coordinates and the time intervals related to each cow detection, were recorded every 20 minutes. Data were collected through a specifically developed AppWeb to be further imported and elaborated by using a GIS software tool. In the GIS environment, the daily distances travelled by each cow were linked with heatmaps obtained by applying Kernel density estimation models from the points obtained from the LP-GPS col-lars. The study results made it possible to obtain information on some relevant aspects of livestock’s environmental issues. In detail, it was possible to acquire information on herd behaviour related to the use of the pasture, e.g., the area of the pasture most frequently used during the day, individual use of the pasture, and possible animal interactions. These results represent the first step towards further insights and research activities because monitoring of animal locations could reduce several environmental issues such as soil degradation and greenhouse emissions. r