Vacuum polarization by a global monopole with finite core

We investigate the effects of a $(D+1)$-dimensional global monopole core on the behavior of a quantum massive scalar field with general curvature coupling parameter. In the general case of the spherically symmetric static core, formulae are derived for the Wightman function, for the vacuum expectation values of the field square and the energy-momentum tensor in the exterior region. These expectation values are presented as the sum of point-like global monopole part and the core induced one. The asymptotic behavior of the core induced vacuum densities is investigated at large distances from the core, near the core and for small values of the solid angle corresponding to strong gravitational fields. In particular, in the latter case we show that the behavior of the vacuum densities is drastically different for minimally and non-minimally coupled fields. As an application of general results the flower-pot model for the monopole's core is considered and the expectation values inside the core are evaluated.Comment: 22 pages, 4 figures, misprint is corrected, discussion is added, figures are change

Stream Fish Fauna From The Tributaries Of The Upper Itapetininga River, Upper Paranapanema River Basin, State Of São Paulo, Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)The study area, which is located in urban and rural areas within the upper Paranapanema River basin, is undergoing several types of anthropogenic and non-anthropogenic impacts, such as chemical alterations, habitat disruption, and biological invasions. The aim of this study is to describe the fish faunal composition from tributaries of the Itapetininga River, upper Paranapanema River basin, state of São Paulo, Brazil. Herein, we include a list of 49 fish species, belonging to seven orders, 19 families and 35 genera, captured from September 2009 to November 2013. Thus, the present study fills part of the knowledge gap about the fish fauna from tributaries of the Paranapanema basin by adding data from small tributaries not studied so far. Moreover, our findings can help inform future conservational and/or management strategies within the upper Paranapanema basin. © 2016 Check List and Authors.12207/50981-7, FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo07/50982-3, FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo2012/09346-4, FAPESP, Fundação de Amparo à Pesquisa do Estado de São PauloFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

Diacerhein attenuates the inflammatory response and improves survival in a model of severe sepsis

2

NEW SEISMIC SOURCE ZONE MODEL FOR PORTUGAL AND AZORES

The development of seismogenic source models is one of the first steps in seismic hazard assessment. In seismic hazard terminology, seismic source zones (SSZ) are polygons (or volumes) that delineate areas with homogeneous characteristics of seismicity. The importance of using knowledge on geology, seismicity and tectonics in the definition of source zones has been recognized for a long time [1]. However, the definition of SSZ tends to be subjective and controversial. Using SSZ based on broad geology, by spreading the seismicity clusters throughout the areal extent of a zone, provides a way to account for possible long-term non-stationary seismicity behavior [2,3]. This approach effectively increases seismicity rates in regions with no significant historical or instrumental seismicity, while decreasing seismicity rates in regions that display higher rates of seismicity. In contrast, the use of SSZ based on concentrations of seismicity or spatial smoothing results in stationary behavior [4]. In the FP7 Project SHARE (Seismic Hazard Harmonization in Europe), seismic hazard will be assessed with a logic tree approach that allows for three types of branches for seismicity models: a) smoothed seismicity, b) SSZ, c) SSZ and faults. In this context, a large-scale zonation model for use in the smoothed seismicity branch, and a new consensus SSZ model for Portugal and Azores have been developed. The new models were achieved with the participation of regional experts by combining and adapting existing models and incorporating new regional knowledge of the earthquake potential. The main criteria used for delineating the SSZ include distribution of seismicity, broad geological architecture, crustal characteristics (oceanic versus continental, tectonically active versus stable, etc.), historical catalogue completeness, and the characteristics of active or potentially-active faults. This model will be integrated into an Iberian model of SSZ to be used in the Project SHARE seismic hazard assessment

COMPILATION OF ACTIVE FAULT DATA IN PORTUGAL FOR USE IN SEISMIC HAZARD ANALYSIS

To estimate where future earthquakes are likely to occur, it is essential to combine information about past earthquakes with knowledge about the location and seismogenic properties of active faults. For this reason, robust probabilistic seismic hazard analysis (PSHA) integrates seismicity and active fault data. Existing seismic hazard assessments for Portugal rely exclusively on seismicity data and do not incorporate data on active faults. Project SHARE (Seismic Hazard Harmonization in Europe) is an EC-funded initiative (FP7) that aims to evaluate European seismic hazards using an integrated, standardized approach. In the context of SHARE, we are developing a fully-parameterized active fault database for Portugal that incorporates existing compilations, updated according to the most recent publications. The seismogenic source model derived for SHARE will be the first model for Portugal to include fault data and follow an internationally standardized approach. This model can be used to improve both seismic hazard and risk analyses and will be combined with the Spanish database for use in Iberian- and European-scale assessments

Influência de magnésio, micronutrientes e calagem no desenvolvimento e fixação simbiótica de nitrogênio na soja perene var. tinaroo ( Glycine wightii ) em solo de cerrado

A greenhouse experiment was carried out with perennial soybeans in a dark-red latosol, using a 25 factorial design, with 3 replications. The objective of this experiment was to study the effect of micro-nutrients, magnesium and lime on growth and symbiotic N2 fixation in perennial soybeans. The following criteria were used to determine the best treatment: dry matter production, total N, nodule weight and % of N, P, K, Ca and Mg in the stems and leaves. Lime had a positive effect on dry matter production with a corresponding increase in total N and % N, P, Ca and Mg. Lime, in the absence of boron, decreased nodule weight. No effect was observe on the variables measured in the study where Mg was added. Boron, in the presence of lime, increased dry matter production, total N and nodule weight. On the other hand, the application of this micronutrient decreased the levels of N, P, K, Ca and Mg in the plant. Zinc also increased dry matter production, total N and nodule weight. Its effect on the % P, % K and % Mg in the plant was negative. Molibdenum in absence of lime increased symbiotic nitrogen fixation by the plant as measured by % and total N.Foi realizado um ensaio em casa de vegetação para estudar o efeito de micronutrientes, magnésio e calagem no desenvolvimento e fixação simbiótica de N em soja perene var. Tinaroo (Glycine wightii) em um latossolo vermelho-escuro fase cerrado. O delineamento experimental utilizado foi um fatorial 25 em blocos ao acaso com três repetições. Foram estudadas as seguintes variáveis: peso seco, N total, peso de nódulos e teores de N, P, K, Ca e Mg na parte aérea. Em face dos dados obtidos concluiu-se que a calagem teve um efeito pronunciado no peso seco, N total e nos teores de N, P, Ca e Mg das plantas. O peso dos nódulos diminuiu com a calagem quando não foi aplicado boro. A aplicação de magnésio não afetou qualquer variável estudada. Nos tratamentos com calagem, o boro aumentou a produção de matéria seca, N total e peso de nódulos, tendo diminuído os teores de N, P, K, Ca e Mg na parte aérea. A interação calagem X zinco foi significativa somente no peso seco das plantas e seu teor de P e K. O molibdênio, quando em ausência de calagem, aumentou o N total e percentual nas plantas

Bayesian Analysis and Constraints on Kinematic Models from Union SNIa

The kinematic expansion history of the universe is investigated by using the 307 supernovae type Ia from the Union Compilation set. Three simple model parameterizations for the deceleration parameter (constant, linear and abrupt transition) and two different models that are explicitly parametrized by the cosmic jerk parameter (constant and variable) are considered. Likelihood and Bayesian analyses are employed to find best fit parameters and compare models among themselves and with the flat $\Lambda$CDM model. Analytical expressions and estimates for the deceleration and cosmic jerk parameters today ($q_0$ and $j_0$) and for the transition redshift ($z_t$) between a past phase of cosmic deceleration to a current phase of acceleration are given. All models characterize an accelerated expansion for the universe today and largely indicate that it was decelerating in the past, having a transition redshift around 0.5. The cosmic jerk is not strongly constrained by the present supernovae data. For the most realistic kinematic models the $1\sigma$ confidence limits imply the following ranges of values: $q_0\in[-0.96,-0.46]$, $j_0\in[-3.2,-0.3]$ and $z_t\in[0.36,0.84]$, which are compatible with the $\Lambda$CDM predictions, $q_0=-0.57\pm0.04$, $j_0=-1$ and $z_t=0.71\pm0.08$. We find that even very simple kinematic models are equally good to describe the data compared to the concordance $\Lambda$CDM model, and that the current observations are not powerful enough to discriminate among all of them.Comment: 13 pages. Matches published versio

Mineralization of Sialoliths Investigated by Ex Vivo and In Vivo X-ray Computed Tomography

The fraction of organic matter present affects the fragmentation behavior of sialoliths; thus, pretherapeutic information on the degree of mineralization is relevant for a correct selection of lithotripsy procedures. This work proposes a methodology for in vivo characterization of salivary calculi in the pretherapeutic context. Sialoliths were characterized in detail by X-ray computed microtomography (μCT) in combination with atomic emission spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. Correlative analysis of the same specimens was performed by in vivo and ex vivo helical computed tomography (HCT) and ex vivo μCT. The mineral matter in the sialoliths consisted essentially of apatite (89 vol%) and whitlockite (11 vol%) with average density of 1.8 g/cm3. In hydrated conditions, the mineral mass prevailed with 53 ± 13 wt%, whereas the organic matter, with a density of 1.2 g/cm3, occupied 65 ± 10% of the sialoliths' volume. A quantitative relation between sialoliths mineral density and X-ray attenuation is proposed for both HCT and μCT.info:eu-repo/semantics/publishedVersio

Synthesis And Evaluation Of New β-carboline-3-(4-benzylidene)- 4h-oxazol-5-one Derivatives As Antitumor Agents

In the present work, we report the synthesis and in vitro anticancer and antimicrobial activity evaluation of a new series of 1-substituted-β- carboline derivatives bearing a 4-benzylidene-4H-oxazol-5-one unity at C-3. The compound 2-[1-(4- methoxyphenyl)-9H-β-carbolin-3-yl]-4-(benzylidene)-4H- oxazol-5-one (11) was the most active derivative, exhibiting a potent cytotoxic activity against glioma (U251), prostate (PC-3) and ovarian (OVCAR-03) cancer cell lines with IC 50 values of 0.48, 1.50 and 1.07 μM, respectively. An in silico study of the ADME properties of the novel synthesized β-carboline derivatives was also performed. © 2012 by the Authors.17561006113Cao, R., Peng, W., Wang, Z., Xu, A., B-carboline alkaloids: Biochemical and pharmacological functions (2007) Curr. Med. Chem., 14, pp. 479-500Yao, K., Zhao, M., Zhang, X., Wang, Y., Li, L., Zheng, M., Peng, S., A class of oral n-[(1s,3s)-1- methyl-1,2,3,4-tetrahydro-β-carboline- 3-carbonyl]-n-(amino-acid-acyl) hydrazine: Discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3d qsar analysis (2011) Eur. J. Med. Chem., 46, pp. 3237-3249Bi, W., Bi, Y., Xue, P., Zhang, Y., Gao, X., Wang, Z., Li, M., Gibson, M.K., A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury (2011) Eur. J. Med. Chem., 46, pp. 1453-1462Liu, J., Jiang, X., Zhao, M., Zhang, X., Zheng, M., Peng, L., Peng, S., A class of 3s-2- aminoacyltetrahydro-b-carboline-3-carboxylic acids: Their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency (2010) J. Med. Chem., 53, pp. 3106-3116Costa, E.V., Pinheiro, M.L.B., De Souza, A.D.L., Barison, A., Campos, F.R., Valdez, R.H., Ueda-Nakamura, T., Nakamura, C.V., Trypanocidal activity of oxoaporphine and pyrimidine-b-carboline alkaloids from the branches of annona foetida mart. (annonaceae (2011) Molecules, 16, pp. 9714-9720Polanski, W., Reichmann, H., Gille, G., Stimulation protection and regeneration of dopaminergic neurons by 9-methyl-b-carboline: A new anti-parkinson drug? (2011) Expert Rev. Neurother., 11, pp. 845-860Valdez, R.H., Tonin, L.T.D., Ueda-Nakamura, T., Silva, S.O., Dias, B.P., Kaneshima, E.N., Yamada-Ogatta, S.F., Nakamura, C.V., In vitro and in vivo trypanocidal synergistic activity of n-butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-b- carboline-3-carboxamide) associated with benznidazole (2012) Antimicrob. Agents Chemother., 56, pp. 507-512Ikeda, R., Kurosawa, M., Okabayashi, T., Takei, A., Yoshiwara, M., Kumakura, T., Sakai, N., Ikekita, M., 3-(3-phenoxybenzyl)amino-b-carboline: A novel antitumor drug targeting a-tubulin (2011) Bioorg. Med. Chem. Lett., 21, pp. 4784-4787Shen, L., Park, E.-J., Kondratyuk, P., Guendisch, D., Marler, L., Pezzuto, J.M., Wright, A.D., Sun, D., Design synthesis, and biological evaluation of callophycin a and analogues as potential chemopreventive and anticancer agents (2011) Bioorg. Med. Chem., 19, pp. 6182-6195Chen, Z., Cao, R., Shi, B., Guo, L., Sun, J., Ma, Q., Fan, W., Song, H., Synthesis and biological evaluation of 1,9-disubstituted b-carbolines as potent dna intercalating and cytotoxic agents (2011) Eur. J. Med. Chem., 46, pp. 5127-5137Zhang, X., Yang, Y., Zhao, M., Liu, L., Zheng, M., Wang, Y., Wu, J., Peng, S., A class of trp-trp-aa-obzl: Synthesis, in vitro anti-proliferation/in vivo anti-tumor evaluation, intercalationmechanism investigation and 3d qsar analysis (2011) Eur. J. Med. Chem., 46, pp. 3410-3419Chen, Z., Cao, R., Shi, B., Yi, W., Yu, L., Song, H., Ren, Z., Synthesis and biological evaluation of novel b-carbolines as potent cytotoxic and dna intercalating agents (2010) Chem. Pharm. Bull., 58, pp. 901-907Ma, C., Cao, R., Shi, B., Zhou, X., Ma, Q., Sun, J., Guo, L., Song, H., Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted b-carbolines (2010) Eur. J. Med. Chem., 45, pp. 5513-5519Chen, Z., Cao, R., Yu, L., Shi, B., Sun, J., Guo, L., Ma, Q., Song, H., Synthesis, cytotoxic activities and dna binding properties of b-carboline derivatives (2010) Eur. J. Med. 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Chem., 16, pp. 9660-9667Savariz, F.C., Formagio, A.S.N., Barbosa, V.A., Foglio, M.A., De Carvalho, J.E., Duarte, M.C.T., Filho, B.P.D., Sarragiotto, M.H., Synthesis, antitumor and antimicrobial activity of novel 1-substituted phenyl-3-[3-alkylamino(methyl)-2-thioxo-1,3,4-oxadiazol-5-yl] b-carboline derivatives (2010) J. Braz. Chem. Soc., 21, pp. 288-298Barbosa, V.A., Formagio, A.S.N., Savariz, F.C., Foglio, M.A., Spindola, H.M., De Carvalho, J.E., Meyer, E., Sarragiotto, M.H., Synthesis and antitumor activity of b-carboline 3- (substitutedcarbohydrazide) derivatives (2011) Bioorg. Med. Chem., 19, pp. 6400-6408Wu, S., Fu, Y., Yan, R., Wu, Y., Lei, X., Ye, S., Synthesis of neamine-carboline conjugates for rna binding and their antibacterial activities (2010) Tetrahedron, 66, pp. 3433-3440Schupp, P., Poehner, T., Edrada, R., Ebel, R., Berg, A., Wray, V., Proksch, P., Eudistomins w and x, two new b-carbolines from the micronesian tunicate eudistoma sp (2003) J. Nat. 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Bianchi Type I Cosmology in Generalized Saez-Ballester Theory via Noether Gauge Symmetry

In this paper, we investigate the generalized Saez-Ballester scalar-tensor theory of gravity via Noether gauge symmetry (NGS) in the background of Bianchi type I cosmological spacetime. We start with the Lagrangian of our model and calculate its gauge symmetries and corresponding invariant quantities. We obtain the potential function for the scalar field in the exponential form. For all the symmetries obtained, we determine the gauge functions corresponding to each gauge symmmetry which include constant and dynamic gauge. We discuss cosmological implications of our model and show that it is compatible with the observational data.Comment: 13 pages, 2 figures, accepted for publication in 'European Physical Journal C