Alien Registration- Caruso, Mary (Millinocket, Penobscot County)

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Modulating lipolysis for nutraceutical and cosmeceutical applications

The first study was conducted to determine if aminophylline cream application to the waist will reduce waist circumference compared to a control. Topical fat reduction from the thigh in women has been demonstrated, but local fat reduction in other areas or in men has not. Fifty men and women were randomized to 0.5% aminophylline cream to the waist twice a day or to no treatment to the waist. At week 12 there was a significant reduction in BMI from baseline that was not different between the groups. The reduction in waist circumference was 11 ± 1.0 cm in the aminophylline cream group and 5.0 ± 0.6 cm in the control group (p\u3c0.001). The reduction in waist circumference was significant for both sexes, but women lost significantly more waist girth. The waist-to-hip ratio declined, aminophylline levels were undetectable, and there were no adverse events. The second study developed a cost-effective method of breast measurement that will allow our research team to test the concept of fat redistribution. Breast volume measurements were compared using the Grossman-Roudner cone, plaster casting, and MRI. Five women with breast sizes AA, A, B, C, and D had three volume measures repeated three times. For a single volume measurement, the costs were: $1 for the Grossman-Roudner cone,$20 for the cast, and $1,400 for the MRI. The relative cost for volume measurements using the cast was 64-189 times greater, and using the MRI was 373-33,500 greater than the cost of the Grossman-Roudner cone. The final study used a human fat cell assay to determine the capacity of currently used mesotherapy solutions to stimulate lipolysis and to determine the effect of combining a local anesthetic to the solutions. The fold induction of the mesotherapy solutions measured by glycerol generation was used to determine their capacity to stimulate lipolysis. Isoproterenol (p\u3c0.002), aminophylline (p\u3c0.00004), and yohimbine (p\u3c0.001) stimulated lipolysis compared to the buffer. The lipolysis stimulated by melilotus and isoproterenol was enhanced by aminophylline (p\u3c0.001). Lidocaine inhibited lipolysis when added to aminophylline and isoproterenol (NS compared to buffer), and when added to aminophylline, isoproterenol, and yohimbine (p\u3c0.05 compared to control)

Qubit channels with small correlations

We introduce a class of quantum channels with correlations acting on pairs of qubits, where the correlation takes the form of a shift operator onto a maximally entangled state. We optimise the output purity and show that below a certain threshold the optimum is achieved by partially entangled states whose degree of entanglement increases monotonically with the correlation parameter. Above this threshold, the optimum is achieved by the maximally entangled state characterizing the shift. Although, a full analysis can only be done for the 2-norm, both numerical and heuristic arguments indicate that this behavior and the optimal inputs are independent of p>1 when the optimal output purity is measured using the p-norm.Comment: 11 pages, 4 figures, 2 table

Novel patient-centered approach to facilitate same-day discharge in patients undergoing elective percutaneous coronary intervention

Background Same‐day discharge ( SDD ) after elective percutaneous coronary intervention is safe, less costly, and preferred by patients, but it is usually performed in low‐risk patients, if at all. To increase the appropriate use of SDD in more complex patients, we implemented a “patient‐centered” protocol based on risk of complications at Barnes‐Jewish Hospital. Methods and Results Our objectives were as follows: (1) to evaluate time trends in SDD ; (2) to compare (a) mortality, bleeding, and acute kidney injury, (b) patient satisfaction, and (c) hospital costs by SDD versus no SDD ( NSDD ); and (3) to compare SDD eligibility by our patient‐centered approach versus Society for Cardiovascular Angiography and Interventions guidelines. Our patient‐centered approach was based on prospectively identifying personalized bleeding, mortality, and acute kidney injury risks, with a personalized safe contrast limit and mitigating those risks. We analyzed Barnes‐Jewish Hospital's National Cardiovascular Data Registry Cath PCI Registry data from July 1, 2009 to September 30, 2015 (N=1752). SDD increased rapidly from 0% to 77% ( P &lt;0.001), independent of radial access. Although SDD patients were comparable to NSDD patients, SDD was not associated with adverse outcomes (0% mortality, 0% bleeds, and 0.4% acute kidney injury). Patient satisfaction was high with SDD . Propensity score–adjusted costs were 7331 lower/ SDD patient ( P <0.001), saving an estimated 1.8 million annually. Only 16 patients (6.95%) met the eligibility for SDD by Society for Cardiovascular Angiography and Interventions guidelines, implying our patient‐centered approach markedly increased SDD eligibility. Conclusions With a patient‐centered approach, SDD rapidly increased and was safe in 75% of patients undergoing elective percutaneous coronary intervention, despite patient complexity. Patient satisfaction was high, and hospital costs were lower. Patient‐centered decision making to facilitate SDD is an important opportunity to improve the value of percutaneous coronary intervention. </jats:sec

Análisis de la percepción e identificación de causas de la inseguridad. Una revisión de la literatura.

Over the years, insecurity has become an uncontrollable situation for most countries in the world because its nature is related to psychological, social, family and economic risk factors that are difficult to detect and eradicate, so that crime has become a constant threat that affects the physical and mental health of the victims, as well as the perception of security. In this article, the perception of insecurity will be analyzed and the critical factors that promote crime levels will be determined, through a bibliographic and scientometric review of research articles found in different databases such as SCOPUS, GOOGLE ACADEMICO and SCIELO, using words keywords such as: “delinquency”; "insecurity" and "crime" and those articles most relevant to the research topic were selected. In the results found, the most determining socioeconomic factors that incite crime were found, which are family, social, psychological and economic. On the other hand, sources were found that affirm that the perception of insecurity can be affected by the way in which the media reports the facts, since they usually apply strategies such as the repetition of news and the use of tension music at the moment of Submit criminal notes.La inseguridad se ha convertido a lo largo de los años en una situación incontrolable para la mayoría de los países del mundo debido a que su naturaleza está relacionada con factores de riesgo psicológicos, sociales, familiares y económicos difíciles de detectar y erradicar, de manera que la delincuencia se ha convertido en una amenaza constante que afecta la salud física y mental de las víctimas, así como la percepción de seguridad. En este artículo se analizará la percepción de inseguridad y se determinarán los factores críticos que propician los niveles de delincuencia, a través de una revisión bibliográfica y cienciometrica de artículos de investigación encontrados en distintas bases de datos como SCOPUS, GOOGLE ACADEMICO y SCIELO, empleando palabras claves como: “delinquency”; “insecurity” y “crime” y se seleccionaron aquellos artículos más relevantes al tema de investigación. En los resultados encontrados se hallaron los factores socioeconómicos más determinantes y que incitan la delincuencia, los cuales son de tipo familiar, social, psicológico y económico. Por otro lado, se encontraron fuentes que afirman que la percepción de inseguridad puede verse afectada por la manera en que los medios de comunicación informan los hechos, ya que suelen aplicar estrategias como la repetición de noticias y el uso de música de tensión al momento de presentar las notas criminales

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO